Wishing you a very Happy Birthday | Prof. Kazuomi Kario

 

 

Prof. Kazuomi Kario serves as the Editor-in-Chief of the Journal “Current Hypertension Reviews”

 

 

Podcast | Hypertension, Diabetes and Neurodegenerative Diseases: Is there a Clinical Link through the Ca2+/cAMP Signalling Interaction?

Author(s): Leandro Bueno Bergantin*.

Journal Name: Current Hypertension Reviews

 

 

For article details, please visit: http://www.eurekaselect.com/164730/article

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ARTICLE TO READ ON WORLD HEART DAY, 2018!

 

Hypertensive Heart Disease and the Role of Aldosterone Antagonists

 

Author(s): Chanwit Roongsritong, Ashwani Kumar, Leigh Ann Jenkins.

 

 

Abstract:

Hypertensive heart disease (HHD) encompasses a spectrum of abnormalities resulting from structural and functional adaptations to chronic pressure overload. The clinical manifestations of HHD range from asymptomatic left ventricular hypertrophy (LVH) to symptomatic heart failure. HHD has been associated with increased risk of cardiovascular morbidity and all cause mortality. However, regression of LVH by antihypertensive therapy has been associated with improved outcome. The pathogenesis of HHD involves various hemodynamic and nonhemodynamic factors including neurohormone, aldosterone. Aldosterone enhances myocardial fibrosis through its direct effect on mineralocorticoid and angiotensin II receptors leading to excessive collagen deposition within the myocardium. Increased myocardial fibrosis is a major determinant of hypertensive remodeling and the transition to heart failure. Aldosterone antagonists are effective antihypertensive agents. Additionally, they have been shown to improve LV structural remodeling, systolic and diastolic function in patients with HHD independent of its effect on blood pressure. Data on long-term benefit of these agents have thus far been limited to patients with advanced systolic heart failure and post-acute myocardial infarction LV systolic dysfunction. The potential benefit of aldosterone antagonists in patients with heart failure and preserved LV systolic function is currently being investigated in large scale clinical trials.

 

For more details, please visit: http://www.eurekaselect.com/59175

ARTICLE TO READ ON World Heart Day, 2018!

The Role of Myocardial Collagen Network in Hypertensive Heart Disease

 

Author(s): Javier Diez, Begona Lopez, Arantxa Gonzalez, Ramon Querejeta.

 

Abstract:

It is time to recognize that the quality, not quantity, of myocardium in hypertensive heart disease is responsible for adverse cardiovascular events. Experimental and clinical available data indicate that myocardial fibrosis due to the exaggerated accumulation of collagen type I and type III fibers predisposes to an enhanced risk of diastolic and/or systolic ventricular dysfunction, symptomatic heart failure, ischemic heart disease, and arrhythmia in patients with hypertensive heart disease. Thus, management of these patients must not only focus on detection and regression of left ventricular hypertrophy. Far more sensible are interventions aimed to detect and target hypertensive myocardial fibrosis. The available data on the use of biochemical and/or imaging methodologies to address excessive accumulation of collagen fibers in the myocardium of hypertensive patients are promising. On the other hand, preliminary data suggest that the goal of reducing myocardial fibrosis is achievable in patients with hypertensive heart disease treated with specific anti hypertensive agents. Collectively, these findings set the stage for larger trials where-in noninvasive measures and reparative strategies of myocardial fibrosis to prevent heart failure could prove useful.

 

For more details, please visit: http://www.eurekaselect.com/58592

World Heart Day, 2018!

 

 

 

World Heart Day is part of an international campaign to spread awareness about heart disease and stroke prevention. This is the perfect day to quit smoking, get exercising and start eating healthy – all in the name of keeping your ticker in good working order, and improving the health and well being of people the world over.

The World Heart Federation have found that heart disease and strokes are the world’s leading cause of death, killing 17.1 million people every year – that’s more than victims of cancer, HIV and AIDS and malaria.

 

Bentham Science publishes articles related to World Heart Day in its Subscription based journals including:

• Current Hypertension Reviews
• Current Cardiology Reviews
• Cardiovascular & Hematological Agents in Medicinal Chemistry

To Avail 20% Discount on related eBooks, kindly visit: https://ebooks.benthamscience.com/

RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

Current Bioactive Compounds 14-2

https://bit.ly/2sRuB8d

Current Topics in Medicinal Chemistry 18-5

https://bit.ly/2JvIWSg

Mini-Reviews in Medicinal Chemistry 18-11

https://bit.ly/2l7XtoF

Current Hypertension Reviews 14-1

https://bit.ly/2MgTgv0

Recent Innovations in Chemical Engineering 11-1

https://bit.ly/2HHqAI5

Current Cancer Drug Targets 18-6

https://bit.ly/2JO5e0P

BENTHAM PRESS RELEASE!

Four Bentham Science Journals indexed in The Emerging Sources Citation Index (ESCI)

The Emerging Sources Citation Index (ESCI), a new database within the Web of Science by Clarivate Analytics, has accepted to index four journals published by Bentham Science Publishers. The titles are:

• Current Drug Therapy
• Current Hypertension Reviews
• Current Women’s Health Reviews
• Current Pediatric Reviews

The Emerging Sources Citation Index (ESCI) is a new index by Clarivate Analytics, extending the range of publications in Web of Science to include high-quality, peer-reviewed publications of regional importance and in emerging scientific fields. ESCI complements the highly selective indexes by providing earlier visibility for sources under evaluation as part of SCIE, SSCI, and AHCI’s rigorous journal selection process. Inclusion in ESCI provides greater discoverability which leads to increased citations.

RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

Neuroscience and Biomedical Engineering Volume 5, Issue 2
http://bit.ly/2DRE3ff

Current Hypertension Reviews Volume 13, Issue 2
http://bit.ly/2FxOCEG

CNS & Neurological Disorders – Drug Targets Volume 16, Issue 8
http://bit.ly/2nuYdoo

Recent Patents on Mechanical Engineering Volume 10, Issue 4
http://bit.ly/2FxOCEG

CNS & Neurological Disorders – Drug Targets Volume 16, Issue 9
http://bit.ly/2EsMO0q

Current Metabolomics Volume 6, Issue 1
http://bit.ly/2nwAB2C

MOST ACCESSED ARTICLE – Potential Role of Endothelin in Early Vascular Aging – Current Hypertension Reviews

Journal: Current Hypertension Reviews

Author(s): Michelle Trindade, Wille Oigman, Mario Fritsch Neves

Graphical Abstract:

 

Abstract:

Early vascular aging is a process associated with gradual alterations in the vessels, regarding their structure and function, taking a more rapid course than normal biological aging in the arteries. In the presence of cardiovascular disease, these age-associated alterations are accelerated, contributing in the appearance or the progression of cardiovascular disease, such as high blood pressure, dyslipidemia, smoking and diabetes. Endothelin-1 (ET-1) is the most abundant and important endothelin produced by vascular cells. ET-1 exerts its biological actions through the activation of two receptors: ETA and ETB. Many important functions are mediated by the activation of these receptors, such as cardiovascular remodeling, vasoconstriction, cell proliferation and differentiation, production of extracellular matrix, and water and sodium secretion control. ETA receptor seems to participate in the pathogenesis and development of diseases, such as diabetes, atherosclerosis, systemic and pulmonary hypertension, and cardiac remodeling after myocardial ischemia, whereas ETB receptor seems to prevent the overstimulation of ETA receptor, acting as a clearance receptor. Increased ET-1 system activity may contribute to vascular dysfunction in aging via multiple pathways, such as direct hemodynamic effects, vascular oxidative stress, inflammatory activity, mitogenic stimulation of the vascular smooth muscle cells and fibrotic processes. Endothelin receptor antagonists were considered to be used for the treatment of some diseases like hypertension, diabetes and chronic kidney disease. However, besides pulmonary hypertension, this class is not in clinical use because of the side effects and the availability of safer drugs for the treatment of these diseases.

To access the article, please visit: http://www.eurekaselect.com/151634

 

EVA – Ageing Of The Blood Vessels Before Time

Celebrating the World Heart Day on September 29^th, we bring our focus to some serious problems related to the heart and vascular system that can lead a human being towards death. One such problem is the ageing of the blood vessels before their actual time. This phenomenon is called Early Vascular Ageing or EVA. Early vascular ageing is a significant marker for cardiovascular diseases and is generally identified by stiffening of the arteries.

EVA is caused when the blood vessels show signs of ageing before they reach their chronological age. This renders the blood vessels to be less flexible and disturbs the control of blood flow from and to the heart. It may occur due to various reasons including genetic factors, environmental effects on vascular system or any damages caused to the blood vessels over time etc. As the researchers, Dr. Stephane Laurent et al. notify in their article published in the journal, Current Hypertension Reviews, EVA is a problem that needs a lot of attention and finding its prevention can ensure many cardiovascular diseases can be combatted.

The article, Early Vascular Ageing (EVA): Definitions and Clinical Applicability, explains the phenomenon, its consequences and opportunities for finding preventive measures.

Find more studies on Early Vascular Ageing here: http://benthamscience.com/journals/current-hypertension-reviews/