MOST ACCESSED ARTICLE – Structure, Function, Involvement in Diseases and Targeting of 14-3-3 Proteins: An Update

Author(s): Ylenia Cau, Daniela Valensin, Mattia Mori, Sara Draghi, Maurizio Botta*.

 

Abstract:

14-3-3 is a class of proteins able to interact with a multitude of targets by establishing protein-protein interactions (PPIs). They are usually found in all eukaryotes with a conserved secondary structure and high sequence homology among species. 14-3-3 proteins are involved in many physiological and pathological cellular processes either by triggering or interfering with the activity of specific protein partners. In the last years, the scientific community has collected many evidences on the role played by seven human 14-3-3 isoforms in cancer or neurodegenerative diseases. Indeed, these proteins regulate the molecular mechanisms associated to these diseases by interacting with (i) oncogenic and (ii) pro-apoptotic proteins and (iii) with proteins involved in Parkinson and Alzheimer diseases. The discovery of small molecule modulators of 14-3-3 PPIs could facilitate complete understanding of the physiological role of these proteins, and might offer valuable therapeutic approaches for these critical pathological states.

 

Read more here: http://www.eurekaselect.com/151895

OPEN ACCESS ARTICLE – Serotonin Receptor Binding Characteristics of Geissoschizine Methyl Ether, an Indole Alkaloid in Uncaria Hook

Journal Name: Current Medicinal Chemistry

Author(s): Yasushi Ikarashi, Kyoji Sekiguchi, Kazushige Mizoguchi*.

 

Abstract:

Background: Geissoschizine methyl ether (GM) is one of the indole alkaloids in Uncaria hook, and an active ingredient of yokukansan (YKS) that improves behavioral and psychological symptoms of dementia (BPSD) in patients with several types of dementia. The pharmacological action of GM has been related to various serotonin (5-HT) receptor subtypes.

Objective: The aim of this article is to review the binding characteristics of GM to the 5-HT receptor subtypes in the brains using our own data and previous findings.

Method: Competitive receptor-binding and agonist/antagonist activity assays for several 5-HT receptor subtypes were performed. Moreover, the articles describing pharmacokinetics and brain distribution of GM were searched in PubMed.

Results: GM bound the following 5-HT receptor subtypes: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5- HT4, 5-HT5A, 5-HT6, and 5-HT7. Among these receptors, GM had partial agonistic activity for 5-HT1A receptors and antagonistic activity for 5-HT2A, 5-HT2B, 5-HT2C, and 5-HT7 receptors. Also, GM was metabolized by various CYP isoforms, mainly CYP3A4. Parent/unchanged GM was detected in both the blood and brain of rats after oral administration of YKS. In the brains, GM was presumed to bind to 5- HT1A, 5-HT2A, 5-HT2B, 5-HT2C, and 5-HT7 receptors on neuron-like large cells mainly in the frontal cortex.

Conclusion: These results suggest that GM is a pharmacologically important alkaloid that regulates various serotonergic activities or functions by binding to multiple 5-HT receptor subtypes. Thus, this review provides recent 5-HT receptor-related evidence that GM is partly responsible for pharmacological effects of YKS.

 

READ MORE HERE: http://www.eurekaselect.com/151003 

PRESS RELEASE: BENTHAM SCIENCE JOURNALS – IMPACT FACTORS 2018

News release date: July 11, 2018

 

The latest edition of Journal Citation Reports® 2018 has been recently published, and according to the report, 41 Bentham Science Publishers (BSP) journals have received Impact Factor ratings. Current Neuropharmacology has continued to top the list with the highest impact factor among all Bentham Science Journals. Current Molecular Pharmacology has also joined the BSP High Impact Journals list with its first JCR Impact Factor rating of 2.481.

 

Here are the top 10 high impact factor journals published by Bentham Science:

  1. Current Neuropharmacology
    Impact Factor: 4.068
  2. Current Medicinal Chemistry
    Impact Factor: 3.469
  3. Current Topics in Medicinal Chemistry
    Impact Factor: 3.374
  4. Current Alzheimer Research
    Impact Factor: 3.289
  5. Current Drug Targets
    Impact Factor: 3.112
  6. Current Pharmaceutical Design
    Impact Factor: 2.757
  7. Current Protein & Peptide Science
    Impact Factor: 2.696
  8. Current Drug Metabolism
    Impact Factor: 2.655
  9. Mini-Reviews in Medicinal Chemistry
    Impact Factor: 2.645
  10. Medicinal Chemistry
    Impact Factor: 2.631

 

Journal Citation Reports (JCR) is an annual publication by Clarivate Analytics. JCR has been integrated with the Web of Science and is accessible from the Web of Science-Core Collections. Its purpose is to offer a systematic means to critically evaluate the world’s leading journals, with quantifiable, statistical information based on citation data.

Bentham Science publishes over 100 print & online scholarly subscription journals and books. Learn more about Bentham Science here.

New Issue :: Current Medicinal Chemistry (Volume: 25, Issue: 21)

Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

 

cmc.jpg

 

Articles from the journal Current Medical Chemistry Volume 25, Issue 21:

  • Targeting Cytosolic Phospholipase A2α for Novel Anti-Inflammatory Agents
  • Nano-Scale Gene Delivery Systems: Current Technology, Obstacles, and Future Directions
  • A Complex Scenario and Underestimated Challenge: The Tumor Microenvironment, ER Stress, and Cancer Treatment
  • Recent Advances in the Development of Antimicrobial Peptides (AMPs): Attempts for Sustainable Medicine?
  • An Update on Potential Molecular Mechanisms Underlying the Actions of Snake Venom L-amino Acid Oxidases (LAAOs) 

     

    For details on the articles, please visit this link ::  https://bit.ly/2NdDIbQ

New Issue :: Current Medicinal Chemistry Volume 25, Issue 20

Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

Articles from the journal Medicinal Chemistry Volume 25, Issue 20:

For details on the articles, please visit this link :: https://bit.ly/2JZgZlf

 

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Current Pediatric Reviews 13, Issue 4
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Current Organic Chemistry 22, Issue 3
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Current Drug Metabolism 19, Issue 1
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Current Medicinal Chemistry 25, Issue 9
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Current Pharmaceutical Biotechnology 18, Issue 13
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RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

Current Molecular Medicine 17, Issue 8
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Current Medicinal Chemistry 25, Issue 7
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Anti-Cancer Agents in Medicinal Chemistry 18, Issue 1
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Mini-Reviews in Medicinal Chemistry 18, Issue 6
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Current Medicinal Chemistry 25, Issue 8
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Current Drug Targets 19, Issue 5
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UPCOMING THEMATIC ISSUE – RECENT DEVELOPMENTS IN ANTI-CANCER DRUG RESEARCH – CURRENT MEDICINAL CHEMISTRY

cmc -THEMATIC FLYER-Ana Maria Faísca Phillips

https://benthamscience.com/journal/special-issues.php?journalID=cmc

UPCOMING THEMATIC ISSUE – HYDROGELS BASED ON NATURAL POLYMERS FOR MEDICINAL APPLICATIONS – CURRENT MEDICINAL CHEMISTRY

CMC-THEMATIC FLYER -Chen Yu

https://benthamscience.com/journals/current-medicinal-chemistry/special-issues/

RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

Current Pharmacogenomics and Personalized Medicine 15-2

http://bit.ly/2FY6tX3

Current Medicinal Chemistry 25-6

http://bit.ly/2tizB8w

Current Alzheimer Research 15-4

http://bit.ly/2FTGobx

Current Topics in Medicinal Chemistry 17-32

http://bit.ly/2Fdw80J

Current Stem Cell Research & Therapy 13-3

http://bit.ly/2FoiCXf 

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