Press Release – Microwave-assisted iodine-catalyzed rapid synthesis of 6H-indolo[2,3-b]quinolines

This article by Dr. Bimal K. Banik et al. is published in Current Microwave Chemistry, Volume 4, 2017

 

Indoloquinoline alkaloids have received significant popularity because of their antimalarial and DNA intercalating properties as well as their use as folk medicines for the control of fever, amoebiasis and malaria. Related metabolites include cryptotackieine and norcryptotackieine which are linear indolo[2,3-b]quinoline alkaloids. These molecules have demonstrated numerous medicinal activities including antimicrobial, and cytotoxicity. They act through DNA intercalation and inhibition of topoisomerase II inhibition. Consequently, organic and medicinal chemists and biologists have become interested in their concise preparation and studies of their biological activities. A few synthetic routes have been developed for the preparation of these structurally unique and complex indole heterocycles. Interestingly, most of these available methods are one-pot methods. For example, high temperature reaction of molecular iodine-catalyzed reaction in diphenyl ether, pivalic acid and ruthenium-exchanged FAU-Y zeolite in 1,4-dioxane is performed. N-Bromosuccinimide at room temperature is found to be good for this purpose. The principal limitation is that almost all of these methods require a very long time. Moreover, the yields of the target molecules are low.

The current research is aimed to develop an efficient synthetic method for the synthesis of indoloquinoline alkaloids mentioned above. Considering the known procedures and analyzing the conditions of the experiments, the iodine-catalyzed tandem method is proved to be excellent. Despite the superiority of iodine, this method produces products with low to moderate yields, requires long reaction time and high temperature. Therefore, an improvement of molecular iodine-catalyzed reaction for this purpose is necessary.

Our research group has been exploring microwave-induced reactions for more than 25 years. Reactions conducted under microwave oven are known to be rapid and successful at much less drastic conditions. Moreover, they also produce the target molecules in better yields without giving side reactions in most of the examples. In conventional methods, unwanted side reactions in many instances lower the yields of the products or produce mixture of products and therefore, isolation of the desired compounds become tedious. On the basis of several successes on microwave-induced chemistry and our interests in the preparation of medicinally useful compounds, we have investigated the preparation of cryptotackieine and norcryptotackieine and their derivatives in automated microwave oven in tightly sealed reaction container.

Indole-3-carboxyaldehyde and two equivalents of aniline in presence of 10 mol% of molecular iodine at 600C and 300 watt power in a sealed vessel are irradiated in an automated microwave. It is interesting to note that the reaction proceeds rapidly with an increase in the yield of the product compared to the conventional heating (oil bath or heating mantle) at much higher temperature. The structure of the starting reactants and products suggests a most probable mechanism. Dehydration to imine from aldehyde and amine, nucleophilic reaction of the imine, annulation and subsequent aromatization occurs in a tandem process in a one-pot method.

This method is extended for the preparation of 6H-indolo[2,3-b]quinolines. As expected, the previously known compounds are synthesized very rapidly and with simple work-up, and without extensive purification. No solvent is used when one of the reactants is liquid or oil. These reactions are also performed in the presence of solvents (THF, MeOH, CHCl3, and CH2Cl2). THF and MeOH are proved to be the best solvent whereas CHCl3 and CH2Cl2 are moderately good for this method.

An expeditious simple and rapid microwave-assisted procedure for the synthesis of significant types of indoloquinolines using molecular iodine as catalyst in a one-pot is developed. The procedure described herein is the first rapid method for the synthesis of novel indoloquinolines. The rate acceleration by microwave-induced method is probably due to the alteration of the transition state of the series of reactions that occur in this tandem process. The benefit of this process is the lowered energy consumption compared to traditional method under reflux or high temperature that requires input of latent heat of vaporization. In this method, vaporization is not possible and so little expenditure of latent heat occurs. The non-ionizing radiation of the microwave is absorbed very efficiently by the reactants and polar solvents and thereby accelerates the process in an unbelievable way.

For more information about the article, please visit: http://www.eurekaselect.com/151565/article

Wishing A Very Happy Birthday Prof. Bimal K. Banik!

Flat Birthday (Square Background Only)_01

 

Prof. Bimal K. Banik

EDITOR-IN-CHIEF: Current Microwave Chemistry Current Organocatalysis

Vice President of Research & Education Development
Community Health Systems of South Texas (CHSST)
Edinburg, TX
USA

New Issue:: Current Microwave Chemistry 4, Issue 1

Current Microwave Chemistry is an international peer-reviewed journal that publishes important contributions describing advances in the use of the microwave in the fields of chemistry, biology, medicine, biomedical science, and engineering. The journal covers microwave-assisted synthesis of novel organic, organometallic and inorganic molecules or complexes, kinetics and mechanistic studies of microwave-induced chemical reactions and potential use of microwave irradiation in the fields of drug discovery, green chemistry, catalysis and industrial process development. It is the premier source of microwave related information for chemists, biologists, pharmacologists and engineers in both industry and academia.

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Articles from the journal Current Microwave Chemistry 4, Issue 1:

For details on the articles, please visit this link :: http://bit.ly/2hUkMCd

New Issue ::: Current Microwave Chemistry, 3 Issue 3

Current Microwave Chemistry is an international peer-reviewed journal that publishes important contributions describing advances in the use of the microwave in the fields of chemistry, biology, medicine, biomedical science, and engineering. The journal covers microwave-assisted synthesis of novel organic, organometallic and inorganic molecules or complexes, kinetics and mechanistic studies of microwave-induced chemical reactions and potential use of microwave irradiation in the fields of drug discovery, green chemistry, catalysis and industrial process development. It is the premier source of microwave related information for chemists, biologists, pharmacologists and engineers in both industry and academia.

Articles from the journal Current Microwave Chemistry, Volume 3 Issue 3:

For details on the articles, please visit this link :: http://bit.ly/2aTYRUg

Testimonial by Dr. Subhash Chander!

 

Dr Subhash Chander

Dr. Subhash Chander

Medicinal Chemistry Research Laboratory, Department of Pharmacy,

Birla Institute of Technology & Science,

Pilani-333031. Rajasthan, India

Contributed Article: A Rapid, Green, Efficient Microwave-Assisted Synthesis and Antimicrobial Activity of Novel Glycinamide of 6, 7-Dimethoxy-1, 2, 3, 4-Tetrahydroisoquinolines

Recent issue of the Journal Current Microwave Chemistry

Recent issue of the Journal Current Microwave Chemistry has been published

Current Microwave Chemistry, Issue 1-2

Aims & Scope

Current Microwave Chemistry is an international peer-reviewed journal that publishes important contributions describing advances in the use of the microwave across the field of in chemistry, biology, medicine, biomedical science, and engineering. The journal covers microwave-assisted synthesis of novel organic, organometallic and inorganic molecules or complexes, kinetics and mechanistic studies of microwave-induced chemical reactions and potential use of microwave irradiation in the fields of drug discovery, green chemistry, catalysis and industrial process development. It is the premier source of microwave related information for chemists, biologists, pharmacologists and engineers in both industry and academia.

http://www.benthamscience.com/journal/index.php?journalID=cmic#top

Abstracted & Indexed in:

Chemical Abstracts Service (CAS).

For more details please visit: http://benthamscience.com/journal/index.php?journalID=cmic