Highlighted Article Flyer for the journal “Current Molecular Medicine”

CMM-Articles_16-10-W-D Zhong

http://benthamscience.com/journals/current-molecular-medicine/

Highlighted Article Flyer for the journal “Current Molecular Medicine”

CMM-Articles_16-10-Yubin Zhou

http://benthamscience.com/journals/current-molecular-medicine/

Highlighted Article Flyer for the journal “Current Molecular Medicine”

CMM-Articles_16-10-Y. Zhou

http://benthamscience.com/journals/current-molecular-medicine/

New Issue :: Current Molecular Medicine 16, Issue 10

Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews, original research articles, short communications/letters and drug clinical trial studies on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal invites guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.

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Articles from the journal Current Molecular Medicine 16, Issue 10:

 

                   For details on the articles, please visit this link :: http://bit.ly/2mYMwYk

 

Article by Disease – “Higher Expression of NOD1 and NOD2 is Associated with Vogt-Koyanagi-Harada (VKH) Syndrome But Not Behcet’s Disease (BD)”

ARTICLE BY DISEASE ON “ORPHAN DISEASES”

Abstract:

NOD1 and NOD2 have been found to play a significant regulatory role in autoimmune disease. To analyze the role of NOD1 and NOD2 in the pathogenesis of Vogt- Koyanagi-Harada (VKH) syndrome and Behcet’s disease (BD). We analyzed the expression of NOD1 and NOD2 from PBMCs by RT-PCR and Western Blot. PBMCs and DCs were cultured with NOD receptor ligands iE-DAP (NOD1) or MDP (NOD2) and cells and supernatants were analyzed by flow cytometry (FCM) and enzyme-linked immunosorbent assay (ELISA). DCs and CD4+T cells were co-cultured with or without stimulation and cells and supernatants were analyzed by FCM and ELISA. A higher expression of NOD1 and NOD2 was observed in patients with active VKH syndrome as compared with controls. However, no significant differences were found between BD patients and controls. Activation of NOD1 and NOD2 with iE-DAP or MDP markedly increased the level of IL-6, TNF-α and IL-1β in PBMCs and DCs and induced the expression of CD40, CD80, CD83, CD86 and HLA-DR on DCs. Activation of NOD1 and NOD2 in DCs promoted the differentiation and proliferation of CD4<sup+< sup=””>T cells. In conclusion, activation of NOD1 or NOD2 increased the production of pro-inflammatory cytokines in PBMCs and promoted the maturation and activation of human DCs in association with stimulation of Th1 and Th17 cells. Our results suggest that over-expression of NOD1 and NOD2 may be involved in the pathogenesis of VKH syndrome.

Read more: http://www.eurekaselect.com/node/140460/article

New Issue :: Current Molecular Medicine 16, Issue 9

Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews, original research articles, short communications/letters and drug clinical trial studies on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal invites guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.

cmm

Articles from the journal Current Molecular Medicine 16, Issue 9:

 

 

Editor’s Choice – “Spinal Muscular Atrophy: More than a Disease of Motor Neurons?”

Journal: Current Molecular Medicine

Author(s): L. A. Nash, J. K. Burns, J. Warman Chardon, R. Kothary and R J Parks

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Abstract:

Spinal muscular atrophy (SMA) is the most common genetically inherited neurodegenerative disease resulting in infant mortality. SMA is caused by genetic deletion or mutation in the survival of motor neuron 1 (SMN1) gene, which results in reduced levels of the survival of motor neuron (SMN) protein. SMN protein deficiency preferentially affects α- motor neurons, leading to their degeneration and subsequent atrophy of limb and trunk muscles, progressing to death in severe forms of the disease. More recent studies have shown that SMN protein depletion is detrimental to the functioning of other tissues including skeletal muscle, heart, autonomic and enteric nervous systems, metabolic/endocrine (e.g. pancreas), lymphatic, bone and reproductive system. In this review, we summarize studies discussing SMN protein’s function in various cell and tissue types and their involvement in the context of SMA disease etiology. Taken together, these studies indicate that SMA is a multi-organ disease, which suggests that truly effective disease intervention may require body-wide correction of SMN protein levels.

Read more here: http://benthamscience.com/journals/current-molecular-medicine/volume/16/issue/9/page/779/

Highlighted Article Flyer for the journal “Current Molecular Medicine”

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http://benthamscience.com/journals/current-molecular-medicine/

 

2016 World Biology and Genetics Congress!

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“2016 World Biology and Genetics Congress” will be held in Dubai, UAE by 9, 10 December 2016.

Sets of relative panels have been assigned as the core theme of this lead and first class event in Biology, Genetics and embryology: Molecular Biology, Genetics and Embryology, Medical Genetics, Cancer Biology and Genetics, Genome Populations and other related areas.

Find out more details: http://www.imperialconference.com/events-and-conferences/

Related journals: Current Genomics & Current Molecular Medicine

A very Happy Birthday to Dr. David W. Li!

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Dr. David W. Li

Editor-in-Chief: Current Molecular Medicine

College of Medicine
University of Nebraska Medical Center
Omaha, NE USA