RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

Current Molecular Medicine 17, Issue 8
https://bit.ly/2vxb2Ws

Current Medicinal Chemistry 25, Issue 7
https://bit.ly/2Hgx8y2

Anti-Cancer Agents in Medicinal Chemistry 18, Issue 1
https://bit.ly/2HggSBd

Mini-Reviews in Medicinal Chemistry 18, Issue 6
https://bit.ly/2qLnhKe

Current Medicinal Chemistry 25, Issue 8
https://bit.ly/2HfMwyK

Current Drug Targets 19, Issue 5
https://bit.ly/2qNNjfZ 

RIA

 

EDITOR’S CHOICE – Role of Zebrafish fhl1A in Satellite Cell and Skeletal Muscle Development – Current Molecular Medicine

Journal: Current Molecular Medicine

Author(s):  F. Chen, W. Yuan, X. Mo, J. Zhuang, Y. Wang, J. Chen, Z. Jiang, X. Zhu, Q. Zeng, Y. Wan, F. Li, Y. Shi, L. Cao, X. Fan, S. Luo, X. Ye, Y. Chen, G. Dai, J. Gao, X. Wang, H. Xie*, P. Zhu*, Y. Li*, X. Wu

Abstract:

Background: Four-and-a-half LIM domains protein 1 (FHL1) mutations are associated with human myopathies. However, the function of this protein in skeletal development remains unclear.

Methods: Whole-mount in situ hybridization and embryo immunostaining were performed.

Results: Zebrafish Fhl1A is the homologue of human FHL1. We showed that fhl1A knockdown causes defective skeletal muscle development, while injection with fhl1A mRNA largely recovered the muscle development in these fhl1A morphants. We also demonstrated that fhl1A knockdown decreases the number of satellite cells. This decrease in satellite cells and the emergence of skeletal muscle abnormalities were associated with alterations in the gene expression of myoD, pax7, mef2ca and skMLCK. We also demonstrated that fhl1A expression and retinoic acid (RA) signalling caused similar skeletal muscle development phenotypes. Moreover, when treated with exogenous RA, endogenous fhl1A expression in skeletal muscles was robust. When treated with DEAB, an RA signalling inhibitor which inhibits the activity of retinaldehyde dehydrogenase, fhl1A was downregulated.

Conclusion: fhl1A functions as an activator in regulating the number of satellite cells and in skeletal muscle development. The role of fhl1A in skeletal myogenesis is regulated by RA signaling.

Read more here: http://www.eurekaselect.com/160312/article

RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

Recent Patents on Engineering 12-1

https://bit.ly/2IiaAwI

Current Molecular Medicine 17-7

https://bit.ly/2GMmy4B

Letters in Organic Chemistry 15-4

https://bit.ly/2uED8yO

Letters in Drug Design & Discovery 15-4

https://bit.ly/2Ec5XSJ

Current Pharmaceutical Biotechnology 18-12

https://bit.ly/2GIVVxH

RIA

EDITOR’S CHOICE – Neuronal Expression of Junctional Adhesion Molecule-C is Essential for Retinal Thickness and Photoreceptor Survival – Current Molecular Medicine

Journal: Current Molecular Medicine

Author(s): Y. Li, F. Zhang, W. Lu*, X. Li*

Abstract:

Background: Photoreceptor cell death is a key pathology of retinal degeneration diseases. To date, the molecular mechanisms for this pathological process remain largely unclear. Junctional adhesion molecule-c (Jam-c) has been shown to play important roles in different biological events. However, its effect on retinal neuronal cells is unknown.

Objective: To determine the effect of Jam-c on adult mouse eyes, particularly, on retinal structure, vasculature and photoreceptor cells, in order to explore potential important target molecules for ocular diseases.

Methods: Jam-c global knockout mice, endothelial-specific and neuronal-specific Jam-c conditional knockout mice using Tie2-Cre and Nestin-Cre mice respectively were used in this study. Mouse eyes were harvested from the different groups and eye size examined. Cryosections of the eyes were made and stained with Hematoxylin and Eosin (H&E) and the thicknesses of retinal layers measured. Retinal blood vessels and cone and rod photoreceptors were analyzed using isolectin B4, peanut agglutinin and rhodopsin as markers respectively. In vivo Jam-c knockdown in mouse eyes was performed by intravitreal injection of Jam-c shRNA. Jam-c expression in the retinae was quantified by real-time PCR.

Results: Global Jam-c gene deletion in mice resulted in smaller eyes and decreased the diameters of lens and iris. Jam-c-/- mice display marked thinning of the outer nuclear layer (ONL), less numbers of photoreceptor cells, and abnormal retinal vasculature. Importantly, neuronal-specific Jam-c deletion led to similar phenotype, whereas no obvious defect was observed in endothelial-specific Jam-c knockout mice. Moreover, Jam-c knockdown by shRNA also decreased ONL thickness and photoreceptor numbers.

Conclusion: We found that Jam-c is critically required for the normal size and retinal structure. Particularly, Jam-c plays important roles in maintaining the normal retinal thickness, vasculature and photoreceptor numbers. Jam-c thus may therefore have important roles in various ocular diseases.

Read more here: http://www.eurekaselect.com/159736/article

 

World Glaucoma Week 2018!

World-Glaucoma-Week-bentham-science

World Glaucoma Week is observed from 8th March to 15th March, 2018. Glaucoma, is an eye diseases that is associated with elevated intraocular pressure, in which damage to the eye (optic) nerve can lead to loss of vision. Glaucoma is the leading cause of irreversible blindness in the world.

Bentham Science publishes papers from prominent medical researchers on Glaucoma. For the best published articles view the following journals:

Current Molecular Medicine 

Infectious Disorders – Drug Targets

RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

Medicinal Chemistry Volume 14, Issue 2
http://bit.ly/2ESFuxH

Clinical Immunology, Endocrine & Metabolic Drugs Volume 4, Issue 1
http://bit.ly/2FhuhVc

Anti-Cancer Agents in Medicinal Chemistry Volume 17, Issue 14
http://bit.ly/2Ca5K5H

Letters in Organic Chemistry Volume 15, Issue 3
http://bit.ly/2BG12fa

Current Molecular Medicine Volume 17, Issue 6
http://bit.ly/2ofkAiZ

Protein & Peptide Letters Volume 24, Issue 12
http://bit.ly/2CxVmk9

recent-issues

RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

Current Physical Chemistry 7 – 4

http://bit.ly/2BGhH2z

MicroRNA 6 – 3

http://bit.ly/2APY58r

Current Molecular Medicine 17 – 4

http://bit.ly/2kdMd9Z

Mini-Reviews in Medicinal Chemistry 18 – 1

http://bit.ly/2CXqTxp

Current Cancer Drug Targets 18 – 1

http://bit.ly/2jdhhpF

Letters in Organic Chemistry  15 – 1

http://bit.ly/2oAE3Nz

Current Pharmaceutical Analysis 14 – 1

http://bit.ly/2CUJl9R

Current Green Chemistry 4 – 2

http://bit.ly/2BCKZyT

Endocrine, Metabolic & Immune Disorders – Drug Targets 18 – 1

http://bit.ly/2BsTxGf

Cardiovascular & Hematological Disorders-Drug Targets 17-2

http://bit.ly/2ySrih3

recent-issues

Testimonial by Farzaneh Bozorg-Ghalati!

Farzaneh Bozorgghalati

Contributed Article: “Molecular Biomarkers Of Anaplastic Thyroid Carcinoma

Wishing A Very Happy Birthday to Dr. David W. Li!

Dr.David W.li

Dr. David W. Li

EDITOR-IN-CHIEF: Current Molecular Medicine

State Key Laboratory of Ophthalmology
Zhongshan Ophthalmic Center
Sun Yat-sen University
Guangzhou, 510060
China

Highlighted Article – Proteotoxic Stress Desensitizes TGF-beta Signaling Through Receptor Downregulation in Retinal Pigment Epithelial Cells – Current Molecular Medicine

CMM-Articles_17- 10-X. Tan

To access this article, please visit: http://www.eurekaselect.com/153421