Reviews on Recent Clinical Trials Volume 13, Issue 1

Central Nervous System Agents in Medicinal Chemistry Volume 18, Issue 1

Drug Delivery Letters Volume 8, Issue 1

Current Nanoscience Volume 14, Issue 2

Current Nanomedicine Volume 8, Issue 1

Current Gene Therapy Volume 17, Issue 5

Nanoscience & Nanotechnology-Asia Volume 8, Issue 1

Adolescent Psychiatry Volume 7, Issue 2


OPEN ACCESS ARTICLE – Early Stages of Antibacterial Damage of Metallic Nanoparticles by TEM and STEM-HAADF – Current Nanoscience

Journal: Current Nanoscience

Author(s): Beatriz Liliana Espana-Sanchez, Carlos Alberto Avila-Orta, Luis Felipe Padilla-Vaca, Enrique Diaz Barriga-Castro, Florentino Soriano-Corral, Pablo Gonzalez-Morones, Diana Guadalupe Ramirez-Wong, Gabriel Luna-Barcenas

Graphical Abstract:



Background: Propagation of pathogens has considered an important health care problem due to their resistance against conventional antibiotics. The recent challenge involves the design of functional alternatives such as nanomaterials, used as antibacterial agents. Early stages of antibacterial damage caused by metallic nanoparticles (NPs) were studied by Transmission Electron Microscopy (TEM) and combined Scanning Transmission Electron Microscopy with High Angle Annular Dark Field (STEM-HAADF), aiming to contribute to the elucidation of the primary antibacterial mechanism of metallic NPs.

Methods: We analyze the NPs morphology by TEM and their antibacterial activity (AA) with different amounts of Ag and Cu NPs. Cultured P. aeruginosa were interacted with both NPs and processed by TEM imaging to determine NPs adhesion into bacteria wall. Samples were analyzed by combined STEM-HAADF to determine the NPs penetration into bacterium and elemental mapping were done.

Results: Both NPs displays AA depending on NPs concentration. TEM images show NPs adhesion on bacterial cells, which produces morphological changes in the structure of the bacteria. STEMHAADF also proves the NPs adhesion and penetration by intracellular localization, detecting Ag/Cu species analyzed by elemental mapping. Moreover, the relative amount of phosphorus (P) and sulfur (S) increases slightly in P. aeruginosa with the presence of NPs. These elements are associated with damaged proteins of the outer cell membrane.

Conclusions: Combined microscopy analyses suggest that the early stages of antibacterial damage caused by alteration of bacterial cell wall, and can be considered a powerful tool aiming to understand the primary antibacterial mechanism of NPs.

Read more here:



Recent Patents on Drug Delivery & Formulation 11-2

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 16-2

Current Medicinal Chemistry 24-39

Current Pharmaceutical Design 23-32

Current Nanoscience 14-1

Recent Patents on Biotechnology 12-1


Highlighted Article – A Novel Non Electrically Prepared Nano Prussian Yellow Film Modified Electrode – Current Nanoscience

CN-Articles_13-6-Ibrahim ALGHORAIBI

Wishing A Very Happy Birthday to Prof. Dae Joon Kang!

prof. Dae Joon Kang.jpg

Prof. Dae Joon Kang

Editor-in-chief: Current Nanoscience

Sungkyunkwan University
South Korea

Wishing A Very Happy Birthday to Dr. Atta-ur-Rahman!

Dr. Atta-ur-Rahman

Dr. Atta-ur-Rahman, FRS

Editor-in-Chief: Current Organic ChemistryMini Reviews in Medicinal ChemistryCurrent Medicinal Chemistry

Honorary Life Fellow
Kings College
University of Cambridge

Podcast: A Review on Nanofluids for Machining – Current Nanoscience

Author(s): Harshit B. Kulkarni, Raviraj M. Kulkarni, Mahantesh M. Nadakatti, Maharudra S. Patil.

For article details, visit:

Subscribe our YouTube channel

Highlighted Article – Acousto-Optic Logic Gate Controlled by Third-Order Nonlinear Optical Effects in Bimetallic Au-Pt Nanoparticles – Current Nanoscience

CN-Articles-13 -6-2017-Carlos Torres-Torres.jpg

New Issue :: Current Nanoscience 13, Issue 2

Current Nanoscience publishes authoritative reviews, original research and highlights, written by experts in the field on all the most recent advances in nanoscience and nanotechnology. All aspects of the field are represented including nano-structures, nano-bubbles, nano-droplets, nanofluids, synthesis, properties, assembly and devices. Applications of nanoscience in biotechnology, medicine, pharmaceuticals, physics, material science and electronics are also covered. The journal is essential to all involved in nanoscience and its applied areas.


Articles from the journal Current Nanoscience 13, Issue 2:

For details on the articles, please visit this link ::




Highlighted Article Flyer for the journal “Current Nanoscience”

CN-Articles_12-6-Zhen Tong