Dr. Liangnian He
Editor in Chief: Current Organic Synthesis
Background: The synthesis of a variety of bisheterocyclic compounds has received a great attention not only as main chain polymers but also because many biologically active natural and synthetic products have molecular symmetry. In the synthesis of bisheterocyclic, researchers tried to extend the existing method by using a broad range of protocols to improve the various scope and limitations regarding their yield, purity and mostly on the various biological applications.
Objective: The significance of this review lies in the fact that bisheterocycles reported here display diverse chemical, structural and biological properties which makes them potential candidates for the further investigations.
Conclusion: This review article is associated with the study of the synthesis and varied applications of different bisheterocycles. These compounds have been built around the variety of intermediate chains such aliphatic, olefinic, alkynic and aromatic linkers. The presence of two heterocyclic moieties together in the same molecule either symmetrically or non-symmetrically has been found to influence the biological profiles of the resultant bis organic molecules. So, there is plenty of scope upon the development of the new bisheterocyclic in order to investigate the effect of the length and flexibility of the linkers upon their biological and other properties.
Background: Polyhydroxyalkanoates (PHAs) are a natural origin biodegradable polyesters consisted of various 3- and 4-hydroxyacid derived repeating units produced by microorganisms as energy storage. PHAs have been intensively studied due to their biodegradability and biocompatibility enabling their use both in packaging and agriculture as well as in medicine and pharmacy. PHAs obtained via biotechnological routes can possess various functional groups in their side chains. However, the diversity in their functionality is limited due to issues of conservation of functional groups during the polymer formation.
Objective: The review focuses on recent progress in the area of synthesis of PHAs functionalized with various reactive as well as bioactive end and side groups.
Conclusion: A potent route to resolve the problem of functional group diversity in natural origin PHAs involves post-polymerization modification, where the desired side groups can be created. On the contrary, synthetically produced PHA analogs obtained directly via ring-opening polymerization of β-lactones offer various functionalities at different position throughout the polymer chain. The desired α- and ω-end groups can be introduced into the polymer chain using specific polymerization, initiation or termination strategies, respectively. The preferred side chain functionality is obtained by choosing the appropriate β-lactone monomers bearing respective functional groups. All functional groups may also be subjected to additional chemical modification. The degradation of PHA as a method for producing functional polymers as well as their possible further applications are also discussed.
Current Organic Chemistry 22, Issue 2
Combinatorial Chemistry & High Throughput Screening 21, Issue 1
Current Topics in Medicinal Chemistry 18, Issue 1
Current Organic Synthesis 15, Issue 1
Current Computer-Aided Drug Design 14, Issue 1
Letters in Drug Design & Discovery 15, Issue 5
Journal: Current Organic Synthesis
Aim and Objective: To explore the use of naturally occurring biodegradable organic acids as a catalyst in organic synthesis. The development of a simple, inexpensive, highly efficient yet ecofriendly catalyst for the synthesis of bis(indolyl)methanes is explored.
Materials and Method: A mixture of indole 1a (1.0 g, 8.53 mmol), benzaldehyde 2a (0.45 g. 4.26 mmol), and itaconic acid (0.12 g, 0.92 mmol, 20 mol%), in H2O (5.0 mL) was refluxed at 100°C for indicated time. After the completion of the reaction (TLC check), the reaction mixture was cooled to room temperature and extracted with ethyl acetate (3 × 5.0 mL), organic layer was dried over Na2SO4 and concentrated under vacuum. The crude residue was purified by column chromatography on silica gel using ethyl acetate:hexane as an eluent.
Results: Initially optimal reaction conditions were developed for the synthesis of bis(indolyl)methanes by selecting model reaction between indole and benzaldehyde. It was found that optimal conditions for the synthesis of bis(indolyl)methanes are use of indole (1.0 mmol), aldehyde (0.5 mmol) and catalyst 20 mol% in water as a solvent, under air atmosphere and at 100°C. Moreover, it was found that aqueous solution of the catalyst can be reused with the same catalytic efficiency for ten times without any pre-treatment. This is an important achievement with regard to the efficiency and reusability of the catalyst in synthesis.
Conclusion: We have shown that itaconic acid in water can be used as an excellent green catalyst with high reusability. It efficiently catalyzes electrophillic substitution reaction of indoles (ESRI) with various aldehydes to give the corresponding BIMs in an efficient manner. Therefore, itaconic acid in water as a catalyst can be a good alternative for the use of hazardous mineral acid and Lewis acid catalyst.
Read more here: http://www.eurekaselect.com/153471/article
Drug Metabolism Letters Volume 11, Issue 2
Current Organic Synthesis Volume 14, Issue 8
Current Drug Targets Volume 19, Issue 3
The Natural Products Journal Volume 8, Issue 1
Current Topics in Medicinal Chemistry Volume 17, Issue 30
Current Pharmaceutical Design Volume 23, Issue 37
Journal: Current Organic Synthesis
Background: Chemists have been interested in light as an energy source to induce chemical reactions since the beginning of scientific chemistry. The organic photochemical reactions do not require toxic or polluting reagents so these reactions presented perspectives in the context of green chemistry and sustainable processes.
Objective: The largest classical divisions of organic chemistry are constituted by heterocycles. The role of heterocyclic compounds in a number of areas cannot be ignored. That’s why the chemists are continuously trying to design and synthesize heterocycles. This review summarizes the chemistry of photochemical reactions with emphasis on their synthetic applications. In this review, the most important photochemical transformations that have been employed in six-membered N-heterocycles synthesis are presented.
Conclusion: This review discussed the research activities in organic photochemistry that are applicable in organic synthesis. This review outlined the synthesis of heterocyclic compounds. Traditional approaches require highly specialized or expensive equipment, are highly inconvenient, or would be of limited use to the synthetic organic chemist. Therefore, these have been omitted by them. Photochemistry can be used to prepare a number of heterocycles selectively, efficiently and in high yield.
Read more here: http://www.eurekaselect.com/149678/article
Current Psychiatry Reviews13-3
Anti-Cancer Agents in Medicinal Chemistry 17-11
Current Medicinal Chemistry 24 -36
Current Organic Chemistry 21-23
Current Organic Synthesis 14 -7
Current Pharmaceutical Design 23-30
Current Drug Targets 18-16
Current Medicinal Chemistry 24 -37
Current Genomics 19 -1
Current Pharmaceutical Design 23 -31