Upcoming Thematic Issue – Oxidative Stress in Neurodegenerative and Psychiatric Disorders – Current Psychopharmacology



Editor’s Choice – Psychiatric Polypharmacy, Etiology and Potential Consequences – Current Psychopharmacology

Journal: Current Psychopharmacology

Author(s): Sonali Sarkar.

Graphical Abstract:



Psychiatric polypharmacy is defined as the use of two or more drugs in the treatment of a psychiatric condition. It is widely prevalent in clinical practice. The rationale for polypharmacy is not clear. Etiologic factors are patient demographics (age, gender, race, low socioeconomic status), personality disorder, psychiatric conditions (psychosis, schizophrenia, affective or mood disorders), comorbidities, severity of disease, treatment- refractoriness, prescribing practice, inpatient or outpatient setting, concern for reduction of extra-pyramidal and other sideeffects. Among children and adolescents’ the polypharmacy correlates are age (13 -15 years), male gender, caucasian race, low socio-economic status, medicaid or public insurance, disability, and foster care or child custody outside of biological family. Pediatric polypharmacy is also associated with a diagnosis of behavioral disorder, autism spectrum disorder, ADHD, conduct disorder/ oppositional defiant disorder, personality disorder, violence, tics, psychosis, affective and mood disorder.


The concurrent administration of multiple drugs increases the risk of drug interactions and adverse effect including morbidity and mortality. Psychiatric polypharmacy is also associated with cumulative toxicity, poor medication adherence and treatment non-compliance. Thus, psychiatric polypharmacy poses a significant public health problem. However, not all polypharmacy is harmful. Polypharmacy is proven to be beneficial in patients with psychotic, mood or affective disorder, concurrently having dual diagnosis with substance abuse, personality disorder and certain medical conditions including thyroid, pain or seizure disorder. Combination therapy with different class of drugs (antidepressants or antipsychotics) with different mechanism of action have beneficial therapeutic consequences. Therefore, a better understanding of physicians’ rationale for polypharmacy, patient tolerability and effectiveness of prescribing strategy is needed to guide practitioners and to inform the development of evidence based treatment guidelines. Here we review the problem of polypharmacy in psychiatric patients, describe possible etiologic factors, associated consequences and provide recommendations for promoting beneficial polypharmacy and reducing harmful polypharmacy in clinical practice.

Upcoming Thematic Issue – Management of Adverse effects of Psychopharmacologic agents in Pediatric Patients – Current Psychopharmacology

CP- THEMATIC FLYER -Donald E. Greydanus MD


Wishing A Very Happy Birthday Dr. Silvio Bellino!

Dr. Silvio Bellino.jpg

Dr. Silvio Bellino

Editor-in-Chief: Current Psychopharmacology

Centre for Personality Disorders, Unit of Psychiatry 1
Department of Neuroscience
University of Turin

Article by Disease – “Geriatric Psychopharmacology in Acute Settings”




Background: Pharmacological management of geriatric patients in acute settings is complex due to the presence of medical comorbidities, risk of drug-drug interactions, and potential patient sensitivity to side effects.

Objectives: This article will review the basic pharmacologic principles of management of older adults in acute settings.

Method: The aforementioned principles will be described and illustrated with two clinical examples. These principles include prioritizing the safety of patients and staff; obtaining a history that is as complete as possible, in order to support the working diagnosis; using the lowest medication dose that controls the symptoms; closely monitoring for side effects and drug-drug interactions; minimizing polypharmacy and discontinuing medications that are no longer necessary; double-checking all orders, so as to avoid medication errors; and involving the patients family and caregivers in treatment planning. Additionally, agents with anticholinergic properties, antipsychotics, benzodiazepines, nonbenzodiazepine hypnotics, and opioids should be used cautiously in older individuals, particularly those with dementia. Practical tips, formulations, dosages, and selected adverse effects of antipsychotics and mood stabilizers used with geriatric patients in acute settings are included.

Results: This clinical review will be useful for psychiatrists and other clinicians who treat older adults in acute medical settings.

Read more: http://www.eurekaselect.com/node/138957/article

World Trauma Day!


Today, on the 17th of October 2016, we raise awareness about the Trauma and related disorders and their possible treatments. Bentham Science Publishers has various research journals dedicated to the Trauma and related disorders. The most significant are;



New Issue ::: Current Psychopharmacology, 5 Issue 2

Current Psychopharmacology publishes peer-reviewed expert reviews, original research articles and single topic guest edited issues on all aspects of pre-clinical and clinical research in psychopharmacology. The journal aims to be the leading forum for expert review articles in the field. The journal also accepts high-level original research articles on outstanding topics of preclinical and clinical psychopharmacology. Data must be published for the first time in Current Psychopharmacology.

Articles from the journal Current Psychopharmacology, Volume 5 Issue 2:

For details on the articles, please visit this link :: http://bit.ly/2bXM1cE

Recently published issues in various journals of Bentham Science

Current Molecular Medicine, 16 Issue 2


Micro and Nanosystems, 7 Issue 3


Current Clinical Pharmacology, 11 Issue 1


 Current Gene Therapy, 16 Issue 1


Current Medicinal Chemistry, 23 Issue 4


Current Cancer Therapy Reviews, 11 Issue 3


Current Biotechnology, 5 Issue 1


Current Psychopharmacology, 4 Issue 2


Recent Issues

“The Role of Oxytocin in Autism Spectrum Disorders”

The research article belongs from the journal Current Psychopharmacology

11042997_795546493870982_5530663597320324574_nAbstract: Autism Spectrum Disorders (ASD) are characterized by dysfunction in three core symptom domains: social impairments, communication impairments, and repetitive behaviours with restricted interests. Oxytocin (OXT) and the structurally similar peptide arginine vasopressin (AVP), may play a role in the etiology of these disorders, especially in the social difficulties domain. Oxytocin is involved in milk let-down and uterine contractions at a peripheral level, while in the brain it predominantly has a neuromodulatory function on affiliative and social behavior. Abnormalities of OXT in ASD are herein reviewed, using blood studies, neuroimaging, and translational research. Genetic abnormalities in OXT have also been consistently reported in ASD. Clinical trials with OXT are currently aimed at reducing social impairments and repetitive behaviours. Finally, the current limitations and prospects for the future of OXT treatment in ASD are discussed.

For more details, visit: http://benthamscience.com/journals/current-psychopharmacology/volume/1/issue/2/page/178/