Podcast: Autoinflammation and Immunomodulation in Inflammatory Fibromyalgia Syndrome- A Review

Author(s): Samy Metyas*, Tamer Rezk, Daniel Arkfeld, Thomas Leptich.

For article details, visit: http://www.eurekaselect.com/145618

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Editor’s Choice – Localized Scleroderma: A Clinical Review – Current Rheumatology Reviews

Journal: Current Rheumatology Reviews

Author(s): Mark Tratenberg, Farrah Gutwein, Varuni Rao, Kirk Sperber, Amy Wasserrman, Julia Ash

Graphical Abstract:



Localized scleroderma (LS) is characterized by excessive collagen deposition leading to thickening of the dermis, subcutaneous tissue or both. The outcome for most patients with localized scleroderma is directly related to the type and stage of the affected tissue. The major challenge for untreated patients is not increased mortality risk, rather deformity and growth defects from skin, muscle and bone abnormalities. Treatment is individualized to type and stage of the lesion and may include pharmacologic and non-pharmacologic therapies. Among the pharmacologic modalities, methotrexate with systemic glucocorticoids is currently the mainstay of treatment. More controlled trials are needed to determine the length of treatment and the maintenance dose of this combination therapy.


Read more here: http://www.eurekaselect.com/145424

World Osteoporosis Day 2017!


World Osteoporosis Day takes place every year on October 20, launching a year-long campaign dedicated to raising global awareness of the prevention, diagnosis and treatment of osteoporosis and metabolic bone disease.

Bentham Science Publishers has various research articles dedicated to the Osteoporosis and bone diseases that can be found in the following journal:

Current Rheumatology Reviews

To Avail 20% Discount on related eBooks, kindly visit: https://ebooks.benthamscience.com/

World Arthritis Day 2017!


World Arthritis Day (WAD) is a global awareness-raising day observed annually on 12th October. Rheumatic and musculoskeletal diseases (RMDs) often receive delayed or no diagnosis. Early diagnosis is key to preventing further damage, but RMDs often receive delayed or no diagnosis. This is often due to a lack of awareness, reducing peoples’ quality of life and affecting physical abilities.

Bentham Science publishes very important research related to this day in the following journals:

Current Rheumatology Reviews

To Avail 20% Discount on related eBooks, kindly visit: https://ebooks.benthamscience.com/

Testimonial by Amit Sharma!

Amit Sharma

Contributed Article: “Scleroderma-like Disorders

Highlighted Article – Low Dose Naltrexone in the Treatment of Fibromyalgia – Current Rheumatology Reviews

CRR-Articles-13 -3-2017-Samy Metyas


Editor’s Choice – “Synovial Inflammation Drives Structural Damage in Hand Osteoarthritis: a Narrative Literature Review”

Journal: Current Rheumatology Reviews

Author(s): Luana Mancarella, Olga Addimanda, Carlotta Cavallari, Riccardo Meliconi

Graphical Abstract:


Background: Ultrasound is one of the most promising candidates for the detection of inflammation and structural damage in hand osteoarthritis.

Objective: To evaluate new advances of US as a diagnostic and prognostic tool in hand osteoarthritis assessment.

Methods: We conducted a Medline on PubMed search for articles about “ultrasonography” and “hand OA” published between January 2012 and 15th April 2016, limiting our search to articles on human adults in English, excluding those involving systemic inflammatory diseases, visualization of joints other than hands, ultrasound guided injections and surgical procedures. Reviews, case reports, letters, position statements and ex vivo studies were excluded. Concordance between ultrasound and conventional radiography and magnetic resonance imaging was evaluated.

Results: Total 46 records were identified, and 16 articles were selected: four showed only ultrasound structural damage (osteophytes, cartilage pathology), six only ultrasound inflammatory variables (synovial thickness, effusion and power Doppler signal), six should considered both ultrasound structural and inflammatory features as well as erosions and two were epidemiological studies. Ultrasound synovitis and power Doppler signal were more frequent in erosive hand osteoarthritis. Followup studies found that ultrasound inflammatory features at baseline are independently associated with radiographic progression; power Doppler signal was the strongest predictor of structural damage. Ultrasound is a reliable tool for cartilage and osteophyte assessment (when performed with static images) and shows a good concordance with magnetic resonance imaging for osteophytes, erosions and synovitis.

Conclusions: Ultrasound detected inflammation may predict radiographic progression and may be used in prospective clinical trials of hand osteoarthritis and in everyday clinical practice.

Read more here: http://www.eurekaselect.com/145495 

Article by Disease – “Distribution of Podoplanin in Synovial Tissues in Rheumatoid Arthritis Patients Using Biologic or Conventional Disease-Modifying Anti-Rheumatic Drugs”




Objective: Podoplanin (PDPN) mediates tumor cell migration and invasion, which phenomena might also play a role in severe rheumatoid arthritis (RA). Therefore, the precise cellular distribution of PDPN and it’s relationships with inflammation was studied in RA treated with biologic disease-modifying anti-rheumatic drugs (DMARD) or conventional DMARDs (cDMARD).

Methods: PDPN+ cells were immunostained by NZ-1 mAb, and scored (3+; >50%/ area, 2+; 20%- 50%, 1+; 5%-20%, 0: <5%) in synovial tissues from RA treated with biologic DMARDs (BIO, n=20) or cDMARD (n=20) for comparison with osteoarthritis (OA, n=5), followed by cell grading of inflammation and cell-typing.

Results: Inflammatory synovitis score was 1.4 in both BIO and cDMARD, compared to only 0.2 in OA. PDPN+ cells were found in the lining layer (BIO 1.6, cDMARD 1.3, OA 0.2) and lymphoid aggregates (BIO 0.6, cDMRD 0.7, OA 0.2), and correlated with RA-inflammation in BIO- and cDMARD-groups in both area (r=0.7/0.9, r=0.6/0.7, respectively p<0.05). PDPN was expressed in CD68+ type A macrophage-like and 5B5+ type B fibroblast-like cells in the lining layer, and in IL- 17+ cells in lymphoid aggregates in RA.

Conclusion: PDPN was markedly increased in the immunologically inflamed RA synovitis, which was surgically treated due to BIO- and cDMARD-resistant RA. PDPN may have potential of a new marker of residual arthritis in local joints for inflammation-associated severe RA.

Read more: http://www.eurekaselect.com/node/140808/article

New Issue :: Current Rheumatology Reviews 13, Issue 1

Current Rheumatology Reviews publishes frontier reviews, original research articles, drug clinical trial studies and guest edited thematic issues on all the latest advances on rheumatology and its related areas e.g. pharmacology, pathogenesis, epidemiology, clinical care and therapy. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field.


Articles from the journal Current Rheumatology Reviews 13, Issue 1:

                          For details on the articles, please visit this link :: http://bit.ly/2mdwx6x






Wishing A Very Happy Birthday To Dr. Serena Guiducci!


Dr. Serena Guiducci

Editor-in-Chief: Current Rheumatology Reviews

Via ML King 65,