EDITOR’S CHOICE – Association between Apolipoproteins AI and B and Ultrasound Indicators of Carotid Atherosclerosis

Journal: Current Vascular Pharmacology

Author(s): Zeljko Zivanovic*, Ivana Divjak, Mirjana Jovicevic, Tamara Rabi-Zikic, Biljana Radovanovic,Svetlana Ruzicka-Kaloci, Djordje Popovic, Edita Stokic, Ksenija Gebauer-Bukurov, Katarina Zivanovic-Vujcic,Petar Slankamenac

Graphical Abstract:

 

Abstract:

Background: Apolipoproteins A-I and B (apoA-I and apoB) may be better indicators of the risk of cardiovascular and cerebrovascular diseases than conventional risk factors (RFs). The onset of ischemic stroke (IS) may be preceded by the development of atherosclerotic changes in carotid arteries, which can be detected by ultrasound. Only a certain % of patients with IS have an (underlying) carotid etiology.

Objective: The aim of our study was to determine the association between ultrasound indicators of carotid atherosclerosis and the presence of apolipoproteins and other biomarkers in patients with IS.

Methods: The study included 120 patients with clinically first, non-cardioembolic ischemic stroke in the carotid circulation. For all patients the following data were recorded: risk factors (hypertension, diabetes, hyperlipoproteinemia, smoking, obesity, metabolic syndrome, (MetS) hyperhomocysteinemia and inflammation), and levels of blood pressure, glucose, glycosylated hemoglobin, lipids, apoA-I and apoB apolipoproteins, body mass index, homocysteine, and C-reactive protein (CRP). Carotid duplex ultrasound was used to measure carotid intima media thickness (cIMT) and determine the presence of an unstable (hypoechogenic) plaque.

Results: The most significant associations were found between cIMT and older age (β=0.230; p=0.006), lower concentrations of apoA-I (β=-0.244; p=0.008) and a higher apoB/apoA-I ratio (β=0.247; p=0.007). The presence of a hypoechogenic plaque was most significantly associated with increased concentrations of apoB (OR=2.29; 95% CI=4.9-173.5; p<0.0001), the presence of MetS (OR=9.2; 95% CI=2.9-29.2; p<0.0001) and elevated CRP (OR=2.7; 95% CI=1.1-6.9; p = 0.046).

Conclusion: Among RFs and their biomarkers, apoA-I, apoB and the apoB/apoA-I ratio showed strong association with ultrasound indicators of carotid atherosclerosis in IS patients.

Read more here: http://www.eurekaselect.com/156319/article

 

RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

Infectious Disorders – Drug Targets 18, Issue 1
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RIA

WISHING A VERY HAPPY BIRTHDAY TO DR. DIMITRI P. MIKHAILIDIS!

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DR. DIMITRI P. MIKHAILIDIS

EDITOR-IN-CHIEF: CURRENT VASCULAR PHARMACOLOGY
ACADEMIC HEAD, DEPARTMENT OF CLINICAL BIOCHEMISTRY,
ROYAL FREE HOSPITAL CAMPUS,
UNIVERSITY COLLEGE LONDON MEDICAL SCHOOL,
UNIVERSITY COLLEGE LONDON (UCL),
POND STREET,
LONDON, NW3 2QG,
UK

RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

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Mini-Reviews in Organic Chemistry Volume 15, Issue 1
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Current Medicinal Chemistry Volume 25, Issue 3
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recent-issues

 

HIGHLIGHTED ARTICLE – A GLYCATION ANGLE TO LOOK INTO THE DIABETIC VASCULOPATHY – CURRENT VASCULAR PHARMACOLOGY

CVP-Articles_15-6-Saheem Ahmad

To access the article, please visit: http://www.eurekaselect.com/151135/article

NEW ISSUE :: Current Vascular Pharmacology 16, ISSUE 1

Current Vascular Pharmacology publishes clinical and research-based reviews, original research articles, letters, debates, drug clinical trial studies and guest edited issues to update all those concerned with the treatment of vascular disease, bridging the gap between clinical practice and ongoing research.

Vascular disease is the commonest cause of death in Westernized countries and its incidence is on the increase in developing countries. It follows that considerable research is directed at establishing effective treatment for acute vascular events. Long-term treatment has also received considerable attention (e.g. for symptomatic relief). Furthermore, effective prevention, whether primary or secondary, is backed by the findings of several landmark trials. Vascular disease is a complex field with primary care physicians and nurse practitioners as well as several specialties involved. The latter include cardiology, vascular and cardio thoracic surgery, general medicine, radiology, clinical pharmacology and neurology (stroke units).

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Articles from the journal Current Vascular Pharmacology, Volume 16, Issue 1:

For details on the articles, please visit this link :: http://bit.ly/2BnnaMf

 

HIGHLIGHTED ARTICLE – UNCONTROLLED HYPERTENSION AND ONCOLOGY – CURRENT VASCULAR PHARMACOLOGY

CVP-Articles_15-6-Moses S. Elisaf

To access the article, please visit: http://www.eurekaselect.com/151613/article

Testimonial by Thomas F. Whayne!

Thomas F. Whayne

Contributed Article: “Medical Management And Risk Reduction of the Cardiovascular Effects of Underwater Diving

Open Access Article – Control of Risk Factors for Cardiovascular Disease among Multinational Patient Population in the Arabian Gulf – Current Vascular Pharmacology

Journal: Current Vascular Pharmacology

Author(s): Ibrahim Al-Zakwani, Wael Al-Mahmeed, Mohamed Arafah, Ali T. Al-Hinai, Abdullah Shehab, Omer Al-Tamimi, Mahmoud Al-Awadhi,Shorook Al-Herz, Faisal Al-Anazi, Khalid Al-Nemer, Othman Metwally, Akram Al-Khadra, Mohammed Fakhry, Hossam Elghetany, Abdel R. Medani,Afzal H. Yusufali, Obaid Al-Jassim, Omar Al-Hallaq, Fahad O.A.S. Baslaib, Haitham Amin, Raul D. Santos, Khalid Al-Waili, Khamis Al-Hashmi,Khalid Al-Rasadi.

Abstract:

We evaluated the control of cardiovascular disease (CVD) risk factors among patients with atherosclerotic cardiovascular disease (ASCVD) in the Centralized Pan-Middle East Survey on the undertreatment of hypercholesterolaemia (CEPHEUS) in the Arabian Gulf. Of the 4398 enrolled patients, overall mean age was 57 ± 11 years, 60% were males, 13% were smokers, 76% had diabetes, 71% had metabolic syndrome and 78% had very high ASCVD risk status. The proportion of subjects with body mass index <25 kg/m2, HbA1c <7% (in diabetics), low-density lipoprotein cholesterol (LDL-C) <2.6 mmol/L (100 mg/dL) and <1.8 mmol/L (70 mg/dL) for high and very high ASCVD risk cohorts, respectively and controlled blood pressure (<140/90 mmHg) was 14, 26, 31% and 60%, respectively. Only 1.4% of the participants had all of their CVD risk factors controlled with significant differences among the countries (P < .001). CVD risk goal attainment rates were significantly lower in those with very high ASCVD risk compared with those with high ASCVD risk status (P < .001). Females were also, generally, less likely to attain goals when compared with males (P < .001).

Read more here: http://www.eurekaselect.com/136029

Testimonial by Konstantinos Tziomalos!

KonstantinosTziomalos

Contributed Article: “Nonalcoholic Fatty Liver Disease Vs. Nonalcoholic Steatohepatitis: Pathological and Clinical Implications