Most Cited Article – Theranostic Applications of Stimulus-Responsive Systems based on Fe2O3

Author(s):Mehrab PourmadadiMohammad Javad AhmadiHomayoon Soleimani DinaniNarges Ajalli and Farid Dorkoosh*

Volume 10, Issue 2, 2022

Published on: 21 April, 2022

Page: [90 – 112]

Pages: 23

DOI: 10.2174/2211738510666220210105113


According to the interaction of nanoparticles with biological systems, enthusiasm for nanotechnology in biomedical applications has been developed in the past decades. Fe2O3 nanoparticles, as the most stable iron oxide, have special merits that make them useful widely for detecting diseases, therapy, drug delivery, and monitoring the therapeutic process. This review presents the fabrication methods of Fe2O3-based materials and their photocatalytic and magnetic properties. Then, we highlight the application of Fe2O3-based nanoparticles in diagnosis and imaging, different therapy methods, and finally, stimulus-responsive systems, such as pH-responsive, magneticresponsive, redox-responsive, and enzyme-responsive, with an emphasis on cancer treatment. In addition, the potential of Fe2O3 to combine diagnosis and therapy within a single particle called theranostic agent will be discussed. Read now:

Most Cited Article – Classification of Diabetes by Kernel Based SVM with PSO

Author(s):Dilip K. Choubey*Sudhakar TripathiPrabhat KumarVaibhav Shukla and Vinay K. Dhandhania

Volume 14, Issue 4, 2021

Published on: 16 July, 2019

Page: [1242 – 1255]

Pages: 14

DOI: 10.2174/2213275912666190716094836


Background: The classification method is required to deduce possible errors and assist the doctors. These methods are used to take suitable decisions in real world applications. It is well known that classification is an efficient, effective and broadly utilized strategy in several applications such as medical diagnosis, etc. The prime objective of this research paper is to achieve an efficient and effective classification method for Diabetes.

Methods: The proposed methodology comprises two phases: The first phase deals with t h e description of Pima Indian Diabetes Dataset and Localized Diabetes Dataset, whereas in the second phase, the dataset has been processed through two different approaches.

Results: The first approach entails classification through Polynomial Kernel, RBF Kernel, Sigmoid Function Kernel and Linear Kernel SVM on Pima Indian Diabetes Dataset and Localized Diabetes Dataset. In the second approach, PSO has been utilized as a feature reduction method followed by using the same set of classification methods used in the first approach. PSO_Linear Kernel SVM provides the highest accuracy and ROC for both the above mentioned dataset.

Conclusion: The present work consists of a comparative analysis of outcomes w.r.t. performance assessment has been done PSO and without PSO for the same set of classification methods. Finally, it has been concluded that PSO selects the relevant features, reduces the expense and computation time while improving the ROC and accuracy. The used methodology could be implemented in other medical diseases. Read now:

E-BOOK – Diagnosis and Treatment in Rheumatology






This book has been written to summarize all key rheumatic diseases into one clear and concise reference text, which includes current treatment and statistics in the field of rheumatology.

This book presents all up to date information that is easily accessible by medical professionals and students.

Emphasis has been placed on precise and early diagnosis of diseases, as well as reports and findings covering current treatments used, as well as alternative therapies which are being investigated.

Each chapter has a clear heading and follows a logical pattern of disease definition, clinical features, epidemiology, pathology, diagnosis and treatment, making it ideal to find information quickly and effectively.

Students may find this book helpful, as the information is presented in facts, short texts and tables, so that the main features of each diseases are highlighted.

This textbook is factual and an easy read, making it ideal in understanding the field of rheumatology, which was after all, the main aim in composing this book.


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MOST ACCESSED ARTICLE – The Challenge of microRNA as a Biomarker of Epilepsy

Journal Name: Current Neuropharmacology

Author(s): Yihong Ma *.


Graphical Abstract:



Background: Epilepsy is one of chronic severe neurological disorders possess to recurring seizures. And now anti-epileptic drugs are only effective in less than one third of epilepsy patients, and biomarkers predicting are not available when the specific antiepileptic drugs treated. Advanced studies have showed that miRNA may be a key in the pathogenesis of epilepsy beginning in the early 2000 years. Several target genes and pathways of miRNA which related to the therapeutic methods to epilepsy.

Method: We searched PubMed from Jan 1,2000 to Jan 1, 2017, using the terms “epilepsy AND microRNA AND biomarker” and “seizure AND microRNA AND biomarker”. We selected articles that featured novel miRNAs in vivo epilepsy models and patients. We then selected the most relevant articles based on a subjective appraisal of their quality and mechanistic insight that could be relevant to epilepsy.

Results: Decrease the expression of has-miR134 could be a potential non-invasive biomarker to use in diagnosis for the epilepsy patients for using hsa-miR-134 also be identified to distinguish patients with and without epilepsy. miR-181a show significant downregulation in the acute stage, but up regulation in the chronic stage and in the latent stage there is no changing and how about this phenomenon appearance in different stage still should be discussed in the future. Besides that, miR- 146a can down-regulated in the patients using genome-wide for serum in circulating miRNAs.miR- 124, miR-199a, and miR-128 etc. could be a candidate for the biomarker in future. miR-15a-5p and -194-5p down-regulated in epilepsy patients, in the future, it may be used as a novel biomarker for improve diagnosis.

Conclusion: These observations give a chance that new development for diagnosis and treatment of epilepsy patients. Advanced technique and miRNA combination may product more effective roles in epilepsy and other disease. These reports will be available to solve the application of miRNAs as biomarkers and novel therapy approaches for epilepsy. In summary, researcher who focus on miRNAs should be understanding of the causes, treatment, and diagnosis of epilepsy. exploration of any of these effects on the efficacy of these drugs is worthwhile.


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Bentham Science is attending  AACR Annual Meeting 2018 held on 14 – 18 April 2018 in Chicago,Illionois. Meet us at Booth no. 1437 and view our range of publications.

AACR Annual Meeting 2018

The mission of the American Association for Cancer Research is to prevent and cure cancer through research, education, communication, and collaboration. Through its programs and services, the AACR fosters research in cancer and related biomedical science; accelerates the dissemination of new research findings among scientists and others dedicated to the conquest of cancer; promotes science education and training; and advances the understanding of cancer etiology, prevention, diagnosis, and treatment throughout the world.

EDITOR’S CHOICE – Diagnosis and Treatment of Drug-Resistant Tuberculosis – Current Respiratory Medicine Reviews

Journal: Current Respiratory Medicine Reviews

Author(s): Rafael Laniado-Laborin

Graphical Abstract:



Background: For decades there were no significant advances in the development of diagnostic procedures for drug resistant TB (DR-TB), or the availability of new, effective drugs specifically developed for DR-TB. Now, we have witnessed during the last decade, the arrival of several new diagnostic techniques and new drugs, already available for clinical use. This review aims to critically analyze evidence-based recommendations on the most recent developments in the diagnosis and treatment of multidrug-resistant tuberculosis (MDR.TB).

Methods: PubMed search for papers describing innovative diagnostic techniques and newer drugs and treatment regimens for MDR-TB. All World Health Organization (WHO) evidence-based guidelines on the subject of diagnostic techniques and new drugs and treatment regimens were also reviewed.

Results: 21 papers, 10 WHO guidelines and one Global Tuberculosis Report (2016) were included in the review. Nineteen were original papers on diagnostic techniques or newer drugs and 2 were editorials on the global burden of MDR-TB. One WHO global report dealt with the burden of MDRTB, 6 guidelines had evidence-based recommendations on newer diagnostic techniques for MDR-TB and 4 had evidence based recommendations on new drugs and treatment regimens for MDR-TB.

Conclusion: The findings of this review confirm that genotypic diagnostic methods have revolutionized the diagnosis of MDR-TB, from a process that used to take months to one that now takes just a few hours. Also, for the first time in more than 50 years, two new antituberculosis drugs, delamanid and bedaquiline, are now added to the armamentarium, a greatly needed alternative for the treatment of MDR-TB.

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World Osteoporosis Day 2017!


World Osteoporosis Day takes place every year on October 20, launching a year-long campaign dedicated to raising global awareness of the prevention, diagnosis and treatment of osteoporosis and metabolic bone disease.

Bentham Science Publishers has various research articles dedicated to the Osteoporosis and bone diseases that can be found in the following journal:

Current Rheumatology Reviews

To Avail 20% Discount on related eBooks, kindly visit:

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