OPEN ACCESS ARTICLE – Mean Diffusivity in the Dopaminergic System and Neural Differences Related to Dopaminergic System

Journal Name: Current Neuropharmacology

Author(s): Hikaru Takeuchi*, Ryuta Kawashima

 

Graphical Abstract:

 

Abstract:

Background: The mean diffusivity (MD) parameter obtained by diffusion tensor imaging provides a measure of how freely water molecules move in brain tissue. Greater tissue density conferred by closely arrayed cellular structures is assumed to lower MD by inhibiting the free diffusion of water molecules.

Methods: In this paper, we review studies showing MD variation among regions of the brain dopaminergic system (MDDS), especially subcortical structures such as the putamen, caudate nucleus, and globus pallidus, in different conditions with known associations to dopaminergic system function or dysfunction. The methodologies and background related to MD and MDDS are also discussed.

Results: Past studies indicate that MDDS is sensitive to pathological derangement of dopaminergic activity, neural changes caused by cognitive and pharmacological interventions that are known to affect the dopaminergic system, and individual character traits related to dopaminergic function.

Conclusion: These results suggest that MDDS can be one useful tool to tap the neural differences related to the dopaminergic system.

 

Read more here: http://www.eurekaselect.com/156969

OPEN ACCESS ARTICLE – Mean Diffusivity in the Dopaminergic System and Neural Differences Related to Dopaminergic System

Journal:  Current Neuropharmacology

Author(s): Hikaru Takeuchi*, Ryuta Kawashima.

Graphical Abstract:

 

Abstract:

Background: The mean diffusivity (MD) parameter obtained by diffusion tensor imaging provides a measure of how freely water molecules move in brain tissue. Greater tissue density conferred by closely arrayed cellular structures is assumed to lower MD by inhibiting the free diffusion of water molecules.

Methods: In this paper, we review studies showing MD variation among regions of the brain dopaminergic system (MDDS), especially subcortical structures such as the putamen, caudate nucleus, and globus pallidus, in different conditions with known associations to dopaminergic system function or dysfunction. The methodologies and background related to MD and MDDS are also discussed.

Results: Past studies indicate that MDDS is sensitive to pathological derangement of dopaminergic activity, neural changes caused by cognitive and pharmacological interventions that are known to affect the dopaminergic system, and individual character traits related to dopaminergic function.

Conclusion: These results suggest that MDDS can be one useful tool to tap the neural differences related to the dopaminergic system.

Read more here: http://www.eurekaselect.com/156969

 

EDITOR’S CHOICE – N-3 (Omega-3) Fatty Acids: Effects on Brain Dopamine Systems and Potential Role in the Etiology and Treatment of Neuropsychiatric Disorders

Journal: CNS & Neurological Disorders – Drug Targets

Author(s): Michelle Healy-Stoffel, Beth Levant

Graphical Abstract:

 

Abstract:

Background & Objective: A number of neuropsychiatric disorders, including Parkinson’s disease, schizophrenia, attention deficit hyperactivity disorder, and, to some extent, depression, involve dysregulation of the brain dopamine systems. The etiology of these diseases is multifactorial, involving genetic and environmental factors. Evidence suggests that inadequate levels of n-3 (omega- 3) polyunsaturated fatty acids (PUFA) in the brain may represent a risk factor for these disorders. These fatty acids, which are derived from the diet, are a major component of neuronal membranes and are of particular importance in brain development and function. Low levels of n-3 PUFAs in the brain affect the brain dopamine systems and, when combined with appropriate genetic and other factors, increase the risk of developing these disorders and/or the severity of the disease. This article reviews the neurobiology of n-3 PUFAs and their effects on dopaminergic function.

Conclusion: Clinical studies supporting their role in the etiologies of diseases involving the brain dopamine systems and the potential of n-3 PUFAs in the treatment of these disorders are discussed.

Read more here: http://www.eurekaselect.com/161234/article

How to be Happy?!

Happiness is the simplest, most important ingredient for good life. It is supposed to be an involuntary feeling that arises without our efforts. It is mostly based on our surroundings, events and happenings. It can be merely described as a good feeling in the mind that you can also feel throughout your body.

Happy business people laughing against white background
Happy business people laughing against white background

But it’s not all that involuntary! Happiness can be triggered through certain activities that we usually do if we want positivity. For instance, we can exercise in the gym and set our positivity hormones, dopamine, free. When we sweat ourselves out in physical workout our mind releases this hormone that soothes our nerves and generates happiness. We are also feeling a sense of accomplishment while pushing that one more bit of our muscle in the exercise. With exercise, we need sleep. When you are deprived of sleep you are bound to feel gloomy. The more hours of sleep you skip in successive nights the more your mood plunges into depression. You then have to cover all the missed hours together to lift your mood.

People are a big source of happiness. You have to spend time with your friends and family. Positive people give you positive vibes. You tend to smile and share the joy. It’s far better than texting or surfing on your phone. Interact with people around you and find your mood on a high!

Recent Issues of Bentham Science Journals have been Published

Inflammation & Allergy-Drug Targets, 13 Issue 4

Aims & scope

Inflammation & #Allergy – Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in inflammation and allergy e.g. disease specific proteins, receptors, enzymes, genes. The journal publishes expert in-depth reviews, original research articles, drug clinical trial studies and guest edited thematic issues covering a range of current topics on drug targets involved in inflammation and allergy. As the discovery, identification, characterization and validation of novel human drug targets for anti-inflammation and allergy drug discovery continue to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.

http://www.eurekaselect.com/124592/issue/4

Abstracted & Indexed in

Chemical Abstracts, BIOSIS, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, MEDLINE/Index Medicus, EMBASE/ExcerptaMedica, Scopus, PubsHub, GenamicsJournalSeek, MediaFinder®-Standard Periodical Directory, and J-Gate..

For details about the latest issues, visit:http://benthamscience.com/journal/index.php?journalID=iadt

 

Current Topics in Medicinal Chemistry, 14 Issue 14

Aims & scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

http://www.eurekaselect.com/124602/issue/14

Abstracted & Indexed in

BIOSIS, Chemical Abstracts, MEDLINE/Index Medicus, PUBMED, ISI, Science Citation Index ExpandedTM, Biochemistry & Biophysics Citation IndexTM, index to Scientific Reviews®, Current Contents®, EMBASE/ExcerptaMedica, Journal Citation Reports/Science Edition, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, Scopus, GenamicsJournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, and J-Gate.

For details about the latest issues, visit:http://benthamscience.com/journal/index.php?journalID=ctmc

 

Mini-Reviews in Organic Chemistry, 11 Issue 3

Aims & scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

http://www.eurekaselect.com/124555/issue/3

Abstracted & Indexed in

BIOSIS, Chemical Abstracts, MEDLINE/Index Medicus, PUBMED, ISI, Science Citation Index ExpandedTM, Biochemistry & Biophysics Citation IndexTM, index to Scientific Reviews®, Current Contents®, EMBASE/ExcerptaMedica, Journal Citation Reports/Science Edition, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, Scopus, GenamicsJournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, and J-Gate

For details about the latest issues, visit:http://benthamscience.com/journal/index.php?journalID=ctmc

 

Current Inorganic Chemistry, 4 Issue 2

Aims & scope

Current Inorganic #Chemistry, a peer-reviewed journal, publishing original research, review articles and guest edited thematic issues in all areas of inorganic chemistry. The journal’s scope includes the synthesis, crystal structure, physical methods, thermodynamics, reactivity, spectroscopy, electronic and bonding properties of significant new and known (bio) inorganic and organometallic compounds.

Current Inorganic Chemistry is an important and reliable source of information on current developments, research and theory in the field. The emphasis is on publishing high quality articles.

http://www.eurekaselect.com/124573/issue/2

Abstracted & Indexed in

Chemical Abstracts, MediaFinder®-Standard Periodical Directory, and J-Gate.

For details about the latest issues, visit: http://benthamscience.com/journal/index.php?journalID=cic

 

Current Drug Targets, 15 Issue 10

Aims & scope

Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes.

Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication mini- & full-length review articles and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

http://www.eurekaselect.com/124609/issue/10

Abstracted & Indexed in

#ChemicalAbstracts, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, Science Citation Index Expanded® (Sci Search), Index to Scientific Reviews®, Biochemistry & Biophysics Citation Index®, PUBMED, BIOSIS, Journal Citation Reports/Science Edition, EMBASE/ExcerptaMedica, MediaFinder-Standard Periodical Directory, Medline, Scopus, EMBASE, Genamics Journal Seek, PubsHub, and J-Gate.

For details about the latest issues, visit: http://benthamscience.com/journal/index.php?journalID=cdt

 

Current Molecular Imaging, 3 Issue 1

Aims & scope

Current Molecular Imaging publishes peer reviewed expert review articles and special topic issues on all aspects of experimental and clinical research in molecular imaging. Topics include the investigative and practical applications of novel radiopharmaceuticals; standard and complicated imaging methodologies and probes; as well as standard and evolving quantitative approaches.

http://www.eurekaselect.com/124654/issue/1

Abstracted & Indexed in

Chemical Abstracts, J-Gate, PubsHub, and Scopus.

For details about the latest issues, visit: http://benthamscience.com/journal/index.php?journalID=cmi

 

Recent Patents on Anti-Infective Drug Discovery, 9 Issue 1

Aims & scope

Recent Patents on Anti-Infective Drug Discovery publishes review and research articles, drug clinical trial studies and guest edited thematic issues on recent patents in the field of anti-infective drug discovery e.g. on novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery. The journal also covers recent research (where patents have been registered) in fast emerging therapeutic areas/targets & therapeutic agents related to anti-infective drug discovery.

http://www.eurekaselect.com/124637/issue/1

Abstracted & Indexed in

PubMed/Medline, Scopus, EMBASE, METADEX, CAB Abstracts, Cambridge Scientific Abstracts (CSA), Chemical Abstracts, GenamicsJournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, and J-Gate.

For details about the latest issues, visit:http://benthamscience.com/journal/index.php?journalID=rpaidd

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