EDITOR’S CHOICE – Advances in Anti-Doping Analytical Approaches – Current Pharmaceutical Analysis

Journal: Current Pharmaceutical Analysis

Author(s): Xianchi Li, Peiying Zhang*

Graphical Abstract:

 

Abstract:

Background: Performance enhancement substances and methods other than exercise training and physical conditioning have become a major problem in athletic competitions. Over the last few years, there has been an increase in the number of these doping approaches used by some athletes, including pharmaceuticals, slightly modified endogenous compounds and also blood transfusions. In order to control and prevent these doping practices by athletes, World Anti-Doping Agency has stipulated several guidelines and approved various methods on the basis of reproducibility, sensitivity and adaptability. The number, design and type of doping substances are increasing on daily basis necessitating the rapid development of analytical methods to detect these substances and to prevent doping.

Objective: In this review, we address the various methodological developments in the last few years to track down the novel doping substances as well as doping methods.

Results: There have been significant advances in the area of mass spectroscopy and the associated detection devices to measure small quantities of test substance or their metabolites in body tissues and fluids. Some of the doping substances have short biological half-life but leave imprints of their action in the form of altered gene expression, protein expression or metabolism, which can be detected by OMICs technologies.

Conclusion: The rapid advance in biological instrumentation and our understanding of the molecular basis of the actions of doping substances have paved the way to enforce ‘true play’ in athletic competitions. But this is an incessant and a continuous process as long as the doping practices continue.

Read more here: http://www.eurekaselect.com/151469/article

 

 

Doping – How it Hurts!?

Whenever there is a major sports event starting, there is always news about anti-doping agencies being active with checking, investigating and clearing/banning athletes from participation. The most recent is the entire Russian Paralympics team getting banned from Rio Olympics 2016. This brings up the question, what is doping at all? Also, how it hurts individuals and rest?

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Doping basically is substance abuse. To simplify it, the athletes are likely to use certain substances that can potentially enhance their performance. The substances or drugs may be hormones or chemicals that activate enzymes and body organs to work more and strongly than usual. But these power boosters come with a catch. They are likely to cause the athletes to face physical and mental problems in certain cases, for instance, kidney failure or neurotic and behavioral issues. Some can be fatal as well if taken in access and against the body’s need.

These are hazards for the athletes on a personal level. On national level and organizational level such cases, if appeared, cause a lot of insult and disgrace. The idea is that the regulators and enforcers at such level are ignorant and fail to guide their athletes.

The situation can be as grave as one can imagine. We all remember Lance Armstrong and his tale of success and disgrace.

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