Editors Choice Article | Crossing the Blood-Brain Barrier: A Review on Drug Delivery Strategies for Treatment of the Central Nervous System Diseases

Journal Name: Current Drug Delivery

Author(s): Nur Izzati Mansor, Norshariza Nordin*, Farahidah Mohamed, King Hwa Ling, Rozita Rosli, Zurina Hassan.

 

 

 

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Abstract:

Many drugs have been designed to treat diseases of the central nervous system (CNS), especially neurodegenerative diseases. However, the presence of tight junctions at the blood-brain barrier has often compromised the efficiency of drug delivery to target sites in the brain. The principles of drug delivery systems across the blood-brain barrier are dependent on substrate-specific (i.e. protein transport and transcytosis) and non-specific (i.e. transcellular and paracellular) transport pathways, which are crucial factors in attempts to design efficient drug delivery strategies. This review describes how the blood-brain barrier presents the main challenge in delivering drugs to treat brain diseases and discusses the advantages and disadvantages of ongoing neurotherapeutic delivery strategies in overcoming this limitation. In addition, we discuss the application of colloidal carrier systems, particularly nanoparticles, as potential tools for therapy for the CNS diseases. To read out more, please visit: http://www.eurekaselect.com/174513/article

Most Accessed Articles – Nanomedicine for Intranasal Delivery to Improve Brain Uptake

Journal Name: Current Drug Delivery

Author(s): Amit A. Patel*, Ravish J. Patel*, Shachi R. Patel.

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Abstract:

Intranasal drug delivery system provides distinct advantage over conventional drug delivery system for a drug that is pharmacokenetically or biologically unstable. Major concern for the treatment of central nervous system diseases is, low concentration of therapeutically active molecule within brain as blood brain barrier is creating obstacle, where intranasal drug delivery provides direct transport of therapeutically active moiety into brain via olfactory or trigeminal pathway. Nasal mucosa provides distinct advantages like improved bioavailability, law dose and quick onset of action and high patient compliance, and the major disadvantage is residence time of drug and irreversible entrapment of drug. This article provides anatomical and physiological information about nasal route and various factors. Article discusses various types of nanoparticles used intranasally and moreover article also emphasizes patents, formulation under development and some.

 

For more details, please visit: http://www.eurekaselect.com/156384

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IDDT-Articles_17-3-Da Yong Lu

http://www.eurekaselect.com/152220/article

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