New Issue | CNS & Neurological Disorders – Drug Targets; Volume 18 Issue 10

 

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CNS & Neurological Disorders – Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes.

CNS & Neurological Disorders – Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

 

Articles from the journal: CNS & Neurological Disorders – Drug Targets; Volume 18 Issue 10

 

 

 

For details on the articles, please visit this link: http://www.eurekaselect.com/node/646/cns-neurological-disorders-drug-targets-/issue/18/2538/10/9564

Press Release | Targeting kinetoplastid and apicomplexan thymidylate biosynthesis as antiprotozoal strategy

 

Kinetoplastid and apicomplexan parasites include protozoans which are responsible for human diseases, and cause a serious impact on human health and the socioeconomic growth of developing countries. Chemotherapy is the main option to control these pathogenic organisms. The organisms’ nuclear metabolism is considered a promising area for the provision of antimicrobial therapeutic targets.

The viability of parasitic protozoa is severely diminished by imparing thymidylate (dTMP) biosynthesis. The absence of enzymatic activities which are specifically involved in the formation of dTMP (e.g. dUTPase, thymidylate synthase, dihydrofolate reductase or thymidine kinase) results in decreased de-oxythymidine triphosphate (dTTP) levels and the so-called thymineless death.

In this process, the ratio of deoxyuridine triphosphate (dUTP) as compared to dTTP in the cellular nucleotide pool has a crucial role. A high dUTP/dTTP ratio leads to uracil misincorporation into DNA, which then leads to the activation of DNA repair pathways, DNA fragmentation and eventually cell death.

For the identification and development of drugs, the essential character of dTMP synthesis has stimulated interest. These agents specifically block the biochemical steps involved in thymine nucleotide formation.

The review covers available literature related to drug discovery of agents targeting thymidylate biosynthesis in kinetoplastid (genera Trypanosoma and Leishmania) and apicomplexan (Plasmodium spp and Toxoplasma gondii) protozoans.The most relevant findings concerning novel inhibitory molecules with anti-parasitic activity against these human pathogens are presented in the review. Read full press release to find out more at: https://www.eurekalert.org/pub_releases/2018-12/bsp-tk122618.php

 

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This article by Dr. Dolores Gonzalez Pacanowska et al. is published in Current Medicinal Chemistry, 2018. The article is available from the following link: http://www.eurekaselect.com/165707

 

HIGHLIGHTED ARTICLE – THE COMPLEXITY OF DEK SIGNALING IN CANCER PROGRESSION – CURRENT CANCER DRUG TARGETS

ccdt-Articles_17- 9-Yong Teng

To access the article, please visit: http://www.eurekaselect.com/152617/article

Highlighted Article Flyer for the journal “Current Drug Targets”

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http://benthamscience.com/journals/current-drug-targets/

Author’s Testimonial

  1. ImageCNS & Neurological Disorders – Drug Target

 I have had a great experience working with Bentham Science Publishers! I published my papers not only in CNS, but in other BSP journals as well. Their publishing process is fast and efficient.

Prof. Sergio Machado, Ph.D.

Institute of Psychiatry, Federal

Univesity of Rio de Janeiro

Brazil

Contributor of Article: High-Frequency rTMS to Treat Refractory Binge Eating Disorder and Comorbid Depression: A Case Report

 

2. Current HIV Research

I am thankful to Bentham Science Publishers for their timely response and quality service to my team. We have just finished submitting our second article for publication, and it will be our immense pleasure to continue working with BSP in future as well.

Dr. Snehal S. Patel

Department of Pharmacology,

Institute of Pharmacy, Nirma University,

Ahmedabad, Gujarat,

India

Contributor of Article:Role of Trim5α in the Suppression of Cross-Species Transmission and its Defence against Human Immunodeficiency Virus

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