Press Release | Hunan University of China has established “PROFESSOR ATTA-UR-REHMAN MEDICINE RESEARCH CENTER”


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Hunan University of Chinese Medicine (HUCM) has established the Academician Professor Atta-ur-Rahman One Belt and One Road TCM Research Center at its main campus at Changsha, the capital city of Hunan province in China.

The inaugural ceremony for the research center was conducted on October 24, 2019, along with Annual Bio-TCM International Conference at HUCM. Dr. Wei Wang, Professor at Hunan University of Chinese Medicine, stated on behalf of the university.

“The University recognizes the contributions of Prof. Dr. Atta-ur-Rahman in the field of traditional medicine. This center is indeed a humble recognition of Prof. Atta-ur-Rahman’s tremendous scientific contributions in the field of traditional medicine, and his leadership of developing scientific collaboration between the two countries.”

Prof. Atta-ur-Rahman has a longstanding association with Bentham Science as the Editor in Chief of Current Medicinal Chemistry, a leading journal in the field of medicinal chemistry.

Dr. Atta-ur-RahmanFRS, is the Editor for Current Medicinal Chemistry. Dr. Rahman won the UNESCO Science Prize and was elected Fellow of the Royal Society (London). He was conferred honorary doctorate degrees by many universities including Cambridge University. He was elected Honorary Life Fellow of King’s College, Cambridge University, and the Austrian government honored him with its high civil award (“Grosse Goldene Ehrenzeischen am Bande”) (2007) .He is Foreign Fellow (“Academician”) of Chinese and Korean Academy of Sciences.

Current Medicinal Chemistry (Impact factor 3.46), is one of the inaugural publications of Bentham Science Publishers. Now in its 26th volume, the journal continues to publish frontier reviews in the field, enabling researchers to stay at the forefront of pharmaceutical design, discovery and synthesis. More information about the journal can be found here. 


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E-BOOK – Essential Techniques for Medical and Life Scientists: A Guide to Contemporary Methods and Current Applications with the Protocols: Part 1







This book focuses on instrumental techniques and their applications in medicine and biological sciences. Chapter 1 discusses mass spectroscopy (MS) and this technique provides qualitative and quantitative measurements of biological samples. MS has several applications but have not been mainly employed in proteomics studies yet. However, recent developments in clinical applications of MS courage researchers to perform difficult assays precisely and rapidly.

Structural elucidation of macromolecules form the basis of molecular biophysics and Chapter 2 discusses X-ray crystallography, Nuclear Magnetic resonance (NMR), Small Angle X-ray scattering (SAXS), and Cryo-electron Microscopy. Without detailed structure of a macromolecule, it is hard to understand the macromolecule interaction in biochemistry. So far, these methods have been employed in biological systems to reveal macromolecule structures. Each method has a unique site as well as overlapping functions however, all of them are useful to structural biologists, pharmaceutical, and medical scientists.

Chapter 3 explains a unique technique; isothermal titration calorimetry (ITC). It is unique since the technique not only measures binding affinity but also it provides thermodynamic data. The thermodynamic data provides nature of interaction. ITC measures any interactions between different macromolecules, DNA, RNA, lipid, carbohydrate, protein (enzyme, antibody), and ligand of any type. The component of the assay may be more than two molecules and there is no molecular weight restriction for the assay. Since it measures heat differences as signal, opaque solutions and suspensions do not restrict measuring binding affinity. ITC also measures enzyme kinetics and the technique may also be coupled to spectroscopic techniques like fluorescence. ITC is an all in one instrument for scientist. The chapter discusses applications of ITC in different disciplines.

Chapter 4 describes a common instrument of life science laboratory; reverse transcription polymerase chain reaction. This powerful method has found applications in medical, diagnosis, and forensics. Methodology and applications of the technique are explained thoroughly in this chapter.

This book is designed not only for early career young scientists (graduate students or postdoctoral associates) but for scientists who are experts in a particular technique but want to use different applications for their experimental set up. Next volume of the book will provide chapters for different analytical techniques.


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E-BOOK – Male Infertility: An Integrative Manual of Western and Chinese Medicine





As mankind has entered the 21st century, the natural ecological and social environment on Earth has undergone major changes, people’s ideas of their own health have also been constantly updated, which makes modern medicine facing more challenges.

Andrology is a new science that studies the structure and function, physiology and pathology of male reproductive system. It is a branch of medical science that combines the basic and clinical research, and involves multidisciplinary mutual penetration. In recent years, great progress has been made in treatment of the male reproductive disorders and sexual dysfunction.

Male infertility is a complex problem, it can be only solved by bringing together medical wisdom and clinical experience of people all over the world.


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E-BOOK – Bone Marrow Aspirate Concentrate and Expanded Stem Cell Applications in Orthopaedics





Advances in surgical practice have always depended upon the introduction of enabling technologies. In the mid 19th century, the introduction of anaesthesia enabled surgeons to develop procedures to remove diseased or damaged tissues. In the mid 20th century, the advent of antibiotics and greater understanding of biocompatibility issues allowed surgeons to replace damaged tissues; the introduction of immunosuppressive therapies extended this technology to transplantation of whole organs. In the latter years of the 20thcentury, advances in computer and imaging technologies provided the tools needed to develop endoscopic interventions. These enabled surgeons to remove diseased tissues with less collateral damage and begin to repair damaged tissues in situ. The 21st century has seen the nascence of stem cell technologies. Surgeons are now seeking ways to employ stem cells to regenerate damaged tissues.



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EDITOR’S CHOICE – The Hippocampal Autophagic Machinery is Depressed in the Absence of the Circadian Clock Protein PER1 that may Lead to Vulnerability During Cerebral Ischemia – Current Neurovascular Research

Journal: Current Neurovascular Research

Author(s): Abdelhaq Rami*, Julia Fekadu, Oliver Rawashdeh


Background: Autophagy is an intracellular bulk self-degrading process in which cytoplasmic contents of abnormal proteins and excess or damaged organelles are sequestered into autophagosomes, and degraded upon fusion with lysosomes. Although autophagy is generally considered to be pro-survival, it also functions in cell death processes. We recently reported on the hippocampal, higher vulnerability to cerebral ischemia in mice lacking the circadian clock protein PERIOD1 (PER1), a phenomenon we found to be linked to a PER1-dependent modulation of the expression patterns of apoptotic/autophagic markers.

Methods: To exclude the contribution of vascular or glial factors to the innate vulnerability of Per1 knockout-mice (Per1−/−-mice) to cerebral ischemia in vivo, we compared the autophagic machinery between primary hippocampal cultures from wild-type (WT)- and Per1−/−-mice, using the lipophilic macrolide antibiotic, Rapamycin to induce autophagy.

Results: Development of autophagy in WT cells involved an increased LC3-II-to-LC3-I ratio (microtubule-associated protein 1 light chain 3) and an overall increase in the level of LC3-II. In addition, immunostaining of LC3 in WT cells revealed the typical transformation of LC3 localization from a diffused staining to a dot- and ring-like pattern. In contrast, Per1−/−-hippocampal cells were resistant to Rapamycin induced alterations of autophagy hallmarks.
Conclusion: Our in vitro data suggests that basal activity of autophagy seems to be modulated by PER1, and confirms the in vivo data by showing that the autophagic machinery is depressed in Per1−/−-hippocampal neurons.The implication of both autophagy and circadian dysfunction in the pathogenesis of cerebral ischemia suggests that a functional connection between the two processes may exist.


Editor’s Pick

ISSN: 1874-7647 (Online)
ISSN: 2211-3320 (Print)
Volume 7, 2 Issues, 2014

Innovations to Control the Environment for Persons with Movement Disorders: Support in Home Care

Author(s): Maria Linden and Anna Akerberg 
Pages 109-126 (18)


 This review focuses on recent innovations and patents with the aim to allow people with movement disorders to control their environment. This particularly includes different technologies for input devices to control computers and other electronic equipment used by persons with movement disorders, enabling the empowerment of this user group. The control of such devices can be the key to social inclusion and mean improved social contact with others, access of information or possibility to work. In this paper, several patents and innovations are described that enable such control, divided into the groups; Input devices in form of switches and touchscreens, Inertia and inclinometer sensors, Voice control and Gesture control. Also methods allowing monitoring and classification of physical activity, i.e. assisting to alarm in case of a fall and systems assisting in rehabilitation at home, are included, as are video games aimed to promote physical activity.

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Editor’s Choice!



Current Drug Safety

ISSN: 2212-3911 (Online)

ISSN: 1574-8863 (Print)

Volume 9, 3 Issues, 2014


The Pattern of Abbreviation Use in Prescriptions: a Way Forward in Eliminating Error-Prone Abbreviations and Standardisation of Prescriptions

Author(s): N. R Samaranayake, P. R.L Dabare, C. A. Wanigatunge and B. M.Y Cheung


Introduction and objectives: Inappropriate abbreviations used in prescriptions have led to medication errors. We investigated the use of error-prone and other unapproved abbreviations in prescriptions, and assessed the attitudes of pharmacists on this issue.

Methods: A reference list of error-prone abbreviations was developed. Prescriptions of outpatients and specialty clinic patients in a teaching hospital in Sri Lanka were reviewed during one month. An interviewer administered questionnaire was used to assess attitudes of pharmacists.


Results: 3370 drug items (989 prescriptions) were reviewed. The mean (standard deviation) number of abbreviations per prescription was 5.9 (3.5). The error-prone abbreviations used in the hospital were, µg (microgram), mcg (microgram), u (units), cc (cubic centimeter), OD (once a day), @ sign, d (days/daily), m (morning) and n (night), and among all prescriptions reviewed, they were used at a rate of 17.4%, 0.1%, 1.9%, 0.2%, 0.2%, 4.9%, 23.5%, 4.4% and 15.8% respectively. Among the 103 types of abbreviations observed, 71 were not standard acceptable abbreviations. Multiple abbreviations were used to indicate a single drug item/ instruction (N = 7). The abbreviation ‘d’ was used to denote ‘daily’ as well as ‘days’. All pharmacists believed that using error-prone abbreviations will always (5.3%) or sometimes (94.7%) lead to medication errors.


Conclusions: Error-prone abbreviations and many other unapproved abbreviations are frequently used in hospitals. There is a need to educating health care professionals on this issue and introduce an in-house error-prone abbreviation list for their guidance

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Editor’s Pick, From Bentham Science Open Astronomy Journal

One of the highly #recommended #article by our Editor in Chief, of the Open Astronomy Journal, is:

Gravity of Rµv = 0 : A New #Paradigm in GR1
Ram Gopal Vishwakarma

#Theory of general relativity (GR) has been scrutinized by experts for almost a century and describes accurately all gravitational phenomena ranging from the solar system to the universe. However, this success is achieved provided one admits three completely independent new components in the energy-stress tensor Tµv-inflaton, dark matter and dark energy, which though do not have any non-gravitational or laboratory evidence and have remained generally speculative. Moreover, the dark energy poses a serious confrontation between fundamental physics and cosmology.

The present situation reminds us of Einstein’s `biggest blunder’ when he forced his theory to predict a static universe, perhaps guided by his religious conviction that the universe must be eternal and unchanging. It seems that we are making a similar blunder by forcing Tµv into the field equations while the observations indicate that it is not needed. We seem to have a deeprooted conviction that the spacetime will remain empty unless we fill it by the energy-stress tensor. However, we have been ignoring numerous evidences earnestly indicating otherwise.

From a critical analysis of the present situation, we develop an entirely new insight about the source of curvature in equations Rµv which, though may appear orthogonal to the usual understanding, is in striking agreement with all known phenomena in GR. Moreover, it answers some hitherto unexplained puzzles and circumvents some long-standing problems of the standard paradigm.

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