Author(s): Alon Seifan, Christine A. Ganzer*, Krista Ryon, Michael Lin, Rahman Mahmudur, Henriquez Adolfo, Cindy Shih, Alan R. Jacobs, Molly Greenwald, Richard S. Isaacson.
Background: Prodromal Neurodegenerative Disease (ND) due to tauopathies such as Alzheimer’s Disease (AD) and Synucleinopathies (SN) such as Parkinson’s Disease (PD) and Dementia with Lewy Bodies (DLB) present subtly. Although ND are considered cognitive disorders, in fact ND present with behavioral and even medical symptomatology years to decades prior to the onset of cognitive changes. Recognizing prodromal ND syndromes is a public health priority because ND is common, disabling and expensive. Diagnosing prodromal ND in real world clinical settings is challenging because ND of the same pathology can present with different symptoms in different people. Individual variability in nature and variability in nurture across the life course influence how ND pathology manifests clinically. The objective of this study was to describe how non-cognitive symptoms from behavioral, medical, neurological and psychiatric domains cluster in prodromal and early stages of ND.
Methods: This was an observational study of patients receiving routine clinical care for memory disorders. All patients receiving a standardized evaluation including complete neurological history and examination and standardized brief neuropsychological testing. A Principal Component Analysis (PCA) considering emotion, motor, sensory and sleep factors was performed on the entire sample of patients in order to identify co-occurring symptom clusters. All patients received a consensus diagnosis adjudicated by at least two dementia experts. Patients were grouped into Cognitively Normal, Detectable Cognitive Impairment, and Mild Cognitive Impairment categories due to AD and/or PD/LBD or NOS pathology. Symptom cluster scores were compared between clinical diagnostic groups. Read out full article at: http://www.eurekaselect.com/169580/article
Author(s): Ryan H. Takahashi*, Jae H. Chang, Jodie Pang, Xiaorong Liang, Shuguang Ma.
Mass balance studies conducted using radiolabeled material (14C or 3H) definitively characterize the Absorption, Metabolism, and Excretion (AME) of a drug. A critical aspect of these studies is that the radiotracer maintains its proportion to total drug from its administration to its complete elimination from the body. In the study of GDC-0276 in beagle dogs, we observed that the 14C radiotracer proportion (specific activity) varied through the study.
High resolution-accurate mass spectrometric measurements of 12C and 14C isotopes of GDC- 0276 and its metabolites in plasma and excreta samples were used to determine the apparent specific activities, which were higher than the specific activity of the dosing formulation. Drug concentrations were adjusted to the observed specific activities to correct the readouts for GDC-0276 AME and PK. Read out full article at: http://www.eurekaselect.com/167902/article
Author(s): Rakesh D. Amrutkar*, Mahendra S. Ranawat.
Currently, new chemical entities developed as anticancer agents against tubulin as a protein target. The present work, a quinazoline derivatives were used to design and synthesized by microwave irradiation as an anticancer agent through selective inhibitors of colchicinebinding site of tubulin by the molecular docking of quinazoline derivatives using Schrödinger, LLC, New York, NY, 2017. Read out full article here: http://www.eurekaselect.com/166586/article
Author(s): Farnoush Faridbod*, Afsaneh L. Sanati.
Graphene and its derivatives, as most promising carbonic nanomaterials have been widely used in design and making electrochemical sensors and biosensors. Graphene quantum dots are one of the members of this family which have been mostly known as fluorescent nanomaterials and found extensive applications due to their remarkable optical properties. Quantum confinement and edge effects in their structures also cause extraordinary electrochemical properties. Read out full article here: http://www.eurekaselect.com/160545/article
Author(s): Momin Khan*, Sehrish Khan, Amir Ul Mulk, Anis Ur Rahman, Abdul Wadood, Sulaiman Shams, Muhammad Ashraf, Jameel Rahman, Iltaf Khan, Abdul Hameed, Zahid Hussain, Abbas Khan, Khair Zaman, Khalid M. Khan, Shahnaz Perveen.
Journal Name: Medicinal Chemistry
Barbituric acid derivatives are a versatile group of compounds which are identified as potential pharmacophores for the treatment of anxiety, epilepsy and other psychiatric disorders. They are also used as anesthetics and have sound effects on the motor and sensory functions. Barbiturates are malonylurea derivatives with a variety of substituents at C-5 position showing resemblance with nitrogen and sulfur containing compounds like thiouracil which exhibited potent anticancer and antiviral activities. Recently, barbituric acid derivatives have also received great interest for applications in nanoscience. Read out full article here: http://www.eurekaselect.com/165349/article
Author(s): Laura Anne Werner*, Marcy Dayan.
Journal Name: Current Women`s Health Reviews
Diastasis Recti Abdominis (DRA) can occur during pregnancy and postpartum. It is defined as an increase of the inter-recti distance (IRD) beyond normal values. The diagnosis of DRA is inconsistent within the literature and varies depending on measurement instrument and activity during measurement (rest versus active curl-up). DRA is characterized by the stretching of linea alba (LA) and contributes to a protrusion of the anterior abdominal wall due to increased laxity in the myofascial system that supports abdominal viscera. DRA has been postulated to affect lumbopelvic support and function due to laxity of the LA and altered angle of muscle insertion, but recent studies have not confirmed this. Risk factors for the development of DRA have been investigated in pregnancy to 12-months postpartum. Read out full article here: http://www.eurekaselect.com/160043/article
Author(s): Erasmus Muh*, Fouzi Tabet, Sofiane Amara.
Cameroon is blessed with a vast potential of energy resources. However, their level of valorization is deplorable causing acute energy challenges. Consequently, most Cameroonians, mainly rural dwellers are dependent on traditional biomass and petroleum products for their basic energy needs despite their associated adverse health and the environmental impacts. Thus, there is a need for alternative, affordable and reliable energy sources to meet this energy gap. This study, therefore, reviews and assesses the prospects and sustainability of biogas production in Cameroon. Read out full article here: http://www.eurekaselect.com/165655/article
Author(s): Xiaolei Zhang, Zhi Li, Jiangtao Gao*.
Abstract: Aspergillus is a genus of ubiquitous fungi that are therapeutically important because the genus produces a wide range of structurally diverse secondary metabolites that are of highly considerable interest to both scientific research community and pharmaceutical industry. Genome sequencing results have indicated that chemical diversity of secondary metabolites is much larger in each species than previously thought.
This review summarizes a total of 315 new secondary metabolites of Aspergillus reported from 2015 to 2017 and demonstrates the therapeutical potential of this genus by introducing their unique chemical structures and excellent bioactivities from this genus. Read out full article here: http://www.eurekaselect.com/161751/article