CALL FOR PAPERS | Thematic Issue for Current Pharmaceutical Design

Journal: Current Pharmaceutical Design

Guest Editor(s): Ling-Qing Yuan
Tentative Publication Date: August, 2019

 

“Novel Strategies for Gene Therapy – Recent Advances in the use of Exosomes for Disease Treatment“

The aim of the present special issue is to invite researchers to contribute review or original research articles reporting the most recent and future therapeutic applications using exosomes in various diseases. Moreover, articles on the synthesis and isolation of exosomes, involvement of exosomes in the pathogenesis of different disease, and the use of exosomes in therapeutic strategies for different diseases are welcome. The objective and critical vision of this advance will be beneficial for us to understand and become familiar with the application of exosomes in treating different diseases. For more details please visit: https://bit.ly/2Je21qG

 

Email here to submit your paper: hermain@benthamscience.net

                                                          CC: faizan@benthamscience.net

 

cpd thematic flyers.jpg

CALL FOR PAPERS | Thematic Issue for Current Pharmaceutical Design

Journal: Current Pharmaceutical Design

 

Novel Strategies for Gene Therapy – Recent Advances in the use of Exosomes for Disease Treatment

 

The aim of the present special issue is to invite researchers to contribute review or original research articles reporting the most recent and future therapeutic applications using exosomes in various diseases. Moreover, articles on the synthesis and isolation of exosomes, involvement of exosomes in the pathogenesis of different disease, and the use of exosomes in therapeutic strategies for different diseases are welcome. The objective and critical vision of this advance will be beneficial for us to understand and become familiar with the application of exosomes in treating different diseases. For more details please visit: https://bit.ly/2Je21qG

 

Guest Editor(s): Ling-Qing Yuan
Tentative Publication Date: August, 2019

Email here to submit your paper:  faizan@benthamscience.net

                     CC: hermain@benthamscience.net 

 

cpd thematic flyers

 

 

EDITOR’S CHOICE ARTICLE –Neuroprotection by Human Dental Pulp Mesenchymal Stem Cells: From Billions to Nano

Journal Name: Current Gene Therapy

Author(s): Chaitra Venugopal, Shobha K, Kiranmai S. Rai, Venkata Bharatkumar Pinnelli,Bindu M. Kutty, nandh Dhanushkodi*.

Abstract:

Introduction: Mesenchymal Stem Cell (MSC) therapy in recent years has gained significant attention. Though the functional outcomes following MSC therapy for neurodegenerative diseases are convincing, various mechanisms for the functional recovery are being debated. Nevertheless, recent studies convincingly demonstrated that recovery following MSC therapy could be reiterated with MSC secretome per se thereby shifting the dogma from cell therapy to cell “based” therapy. In addition to various functional proteins, stem cell secretome also includes extracellular membrane vesicles like exosomes. Exosomes which are of “Nano” size have attracted significant interest as they can pass through the bloodbrain barrier far easily than macro size cells or growth factors. Exosomes act as a cargo between cells to bring about significant alterations in target cells. As the importance of exosomes is getting unveil, it is imperial to carry out a comprehensive study to evaluate the neuroprotective potential of exosomes as compared to conventional co-culture or total condition medium treatments.

Objective: Thus, the present study is designed to compare the neuroprotective potential of MSC derived exosomes with MSC-condition medium or neuron–MSC-co-culture system against kainic acid induced excitotoxicity in in vitro condition. The study also aims at comparing the neuroprotective efficacy of exosomes/condition medium/co-culture of two MSC viz., neural crest derived human Dental Pulp Stem Cells (hDPSC) and human Bone-Marrow Mesenchymal Stem Cells (hBM-MSC) to identify the appropriate MSC source for treating neurodegenerative diseases.

Result: Our results demonstrated that neuroprotective efficacy of MSC-exosomes is as efficient as MSC-condition medium or neuron-MSC co-culture system and treating degenerating hippocampal neurons with all three MSC based approaches could up-regulate host’s endogenous growth factor expressions and prevent apoptosis by activating cell survival PI3K-B-cell lymphoma-2 (Bcl-2) pathway.

Conclusion: Thus, the current study highlights the possibilities of treating neurodegenerative diseases with “Nano” size exosomes as opposed to transplanting billions of stem cells which inherit several disadvantages.

 

For more details, please visit: http://www.eurekaselect.com/165433/article

MOST ACCESSED ARTICLE – Mesenchymal Stem Cells-Derived Exosomes: A Possible Therapeutic Strategy for Osteoporosis

Journal Name: Current Stem Cell Research & Therapy

Author(s): Yue Li, Daxiang Jin*, Weixing Xie, Longfei Wen, Weijian Chen, Jixi Xu, Jinyong Ding, Dongcheng Ren, Zenglin Xiao.

 

 

 

Abstract:

Osteoporosis is a common age-related disorder characterized by low bone mass and deterioration in bone microarchitecture, leading to increased skeletal fragility and fracture risk. The pathophysiology of osteoporosis is multifactorial. It is related to the imbalance between osteoblasts and osteoclasts; reduced bone mass and increased adipogenesis in the bone marrow. Moreover, angiogenesis, inflammatory process and miRNAs have shown effects in the formation of osteoporosis. In the recent years, mesenchymal stem cells (MSCs) have been regarded as an excellent choice for cell-based tissue engineering therapy of osteoporosis. Growing evidence showed that paracrine effect has been considered as the predominant mechanism for the role of MSCs in tissue repair. Recently, many studies have proposed that MSCs-derived exosomes are effective for a variety of diseases like cancer, cardiovascular diseases, etc. However, whether the MSCs-derived exosomes could serve as a novel therapeutic tool for osteoporosis has not clearly described. In this review, we summarize the MSCs-derived exosomes and the relationship with osteogenesis, osteoclast differentiation, angiogenesis, immune processes and miRNAs. Finally, we suggest that MSCs-derived exosomes might be a promising therapeutic method for osteoporosis in the future.

 

For more details, please visit: http://www.eurekaselect.com/160963

Editor’s Choice – Mesenchymal Stem Cell-derived Extracellular Vesicles for Renal Repair – Current Gene Therapy

Journal: Current Gene Therapy

Author(s): Arash Aghajani Nargesi, Lilach O. Lerman, Alfonso Eirin.

Abstract:

Introduction: Transplantation of autologous mesenchymal stem cells (MSCs) has been shown to attenuate renal injury and dysfunction in several animal models, and its efficacy is currently being tested in clinical trials for patients with renal disease. Accumulating evidence indicates that MSCs release extracellular vesicles (EVs) that deliver genes, microRNAs and proteins to recipient cells, acting as mediators of MSC paracrine actions. In this context, it is critical to characterize the MSC-derived EV cargo to elucidate their potential contribution to renal repair. In recent years, researchers have performed high-throughput sequencing and proteomic analysis to detect and identify genes, microRNAs, and proteins enriched in MSC-derived EVs.

Conclusion: The present review summarizes the current knowledge of the MSC-derived EV secretome to shed light into the mechanisms mediating MSC renal repair, and discusses preclinical and clinical studies testing the efficacy of MSC-derived EVs for treating renal disease.
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