New Issue | CNS & Neurological Disorders – Drug Targets; Volume 18 Issue 10

 

 

CNS & Neurological Disorders – Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes.

CNS & Neurological Disorders – Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

 

Articles from the journal: CNS & Neurological Disorders – Drug Targets; Volume 18 Issue 10

• Omega-3 Fatty Acids as Druggable Therapeutics for Neurodegenerative Disorders
• Pharmacotherapy of Down’s Syndrome: When and Which?
• Neurobehavioral Consequences Associated with Long Term Tramadol Utilization and Pathological Mechanisms
• A Review for Lithium: Pharmacokinetics, Drug Design, and Toxicity
• Structurally Related Edaravone Analogues: Synthesis, Antiradical, Antioxidant, and Copper-Chelating Properties
• Somatostatin Type 2 Receptor Antibody Enhances Mechanical Hyperalgesia in the Dorsal Root Ganglion Neurons after Sciatic Nerve-pinch Injury: Evidence of Behavioral Studies and Bax Protein Expression
• Synthesis and Evaluation of N-substituted (Z)-5-(Benzo[d][1,3]dioxol-5- ylmethylene)-2-Thioxothiazolidin-4-one Derivatives and 5-Substituted- Thioxothiazolidindione Derivatives as Potent Anticonvulsant Agents

 

 

 

For details on the articles, please visit this link: http://www.eurekaselect.com/node/646/cns-neurological-disorders-drug-targets-/issue/18/2538/10/9564

CALL FOR PAPERS | Thematic Issue for Current Alzheimer Research

Special Thematic Issues | Forthcoming Issues

Journal: Current Alzheimer Research

Guest Editor(s): Keshen Li
Tentative Publication Date: July, 2019

 

Systems Genetics of Alzheimer’s disease: From GWAS to
Disease Pathways

 

Alzheimer’s disease (AD) is the most common dementia and neurodegenerative disease in the elderly. AD is highly heritable and complex. In recent years, genetic studies especially genomewide association studies (GWAS) and next-generation sequencing have identified several AD risk variants and pathways associated with the potential pathogenesis and genetic mechanisms of AD. Until now, more than 20 risk loci that affect AD have been identified. These loci are estimated to explain about 28% of the heritability of liability, 30% of familial risk, and over 50% of sibling recurrence risk of developing AD. Despite these successes, the majority of genetic risk remains to be further identified. The identification of the causative variants or mutations remains challenging and the molecular mechanisms are still rarely characterized. In the post-genome era, the major challenge is to mine novel disease risks from multi-level omics data using system biology methods, which may expand our knowledge of the causes of AD. Therefore, we propose a Special Issue of the topic ‘Systems genetics of Alzheimer’s disease: From GWAS to disease
pathways’. This special issue will focus on the mechanism of genesis and development of AD, as well as valuable clues for the development of novel therapeutic approaches of AD. We believe the systems genetics will help us move from disease risk loci to disease aetiology. This Special Issue welcomes reviews and original papers covering recent genetic research on AD using system biology methods. For more details please visit: https://bit.ly/2M2i6mo

 

Email here to submit your paper: hermain@benthamscience.net

                                                          CC: faizan@benthamscience.net

CALL FOR PAPERS | Thematic Issue for Current Medicinal Chemistry

Special Thematic Issues | Forthcoming Issues

Journal: Current Alzheimer Research

Guest Editor(s): Keshen Li
Tentative Publication Date: July, 2019

 

Systems Genetics of Alzheimer’s disease: From GWAS to
Disease Pathways

 

Alzheimer’s disease (AD) is the most common dementia and neurodegenerative disease in the elderly. AD is highly heritable and complex. In recent years, genetic studies especially genomewide association studies (GWAS) and next-generation sequencing have identified several AD risk variants and pathways associated with the potential pathogenesis and genetic mechanisms of AD. Until now, more than 20 risk loci that affect AD have been identified. These loci are estimated to explain about 28% of the heritability of liability, 30% of familial risk, and over 50% of sibling recurrence risk of developing AD. Despite these successes, the majority of genetic risk remains to be further identified. The identification of the causative variants or mutations remains challenging and the molecular mechanisms are still rarely characterized. In the post-genome era, the major challenge is to mine novel disease risks from multi-level omics data using system biology methods, which may expand our knowledge of the causes of AD. Therefore, we propose a Special Issue of the topic ‘Systems genetics of Alzheimer’s disease: From GWAS to disease
pathways’. This special issue will focus on the mechanism of genesis and development of AD, as well as valuable clues for the development of novel therapeutic approaches of AD. We believe the systems genetics will help us move from disease risk loci to disease aetiology. This Special Issue welcomes reviews and original papers covering recent genetic research on AD using system biology methods. For more details please visit: https://bit.ly/2M2i6mo

Email here to submit your paper: hermain@benthamscience.net

                                                          CC: faizan@benthamscience.net

AIMS & SCOPE – CNS & Neurological Disorders – Drug Targets

Aims & Scope

CNS & Neurological Disorders – Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes.

CNS & Neurological Disorders – Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

 

 

For more details, please visit: https://benthamscience.com/journals/cns-and-neurological-disorders-drug-targets/aims-scope/#top 

Highlighted Article Flyer for the journal “Current Gene Therapy”

http://benthamscience.com/journals/current-gene-therapy/

Recently Published Issue Of the Journal Current Genomics

Current Genomics is a peer-reviewed journal that provides essential reading for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments in genome science and systems modeling.

Current Genomics publishes three types of peer-reviewed articles including:

1. i) High-qualityresearch papersreporting on new and original data generated at the genome scale level, including meta-analysis studies. Systems biology, molecular systems modeling, molecular evolution, developmental biology, aging research and human disease research are topics of particular interest. Position papers dealing with new or complex methodological approaches whether experimental or mathematical are greatly welcome in this section.
2. ii) Authoritative and comprehensivereviewsfrom widely-recognized experts, covering all the latest and outstanding developments in genome science and computational/systems biology. Proposals for mini-hot topics (2-3 review papers) and full hot topics (6-8 review papers) are welcome in this section and they should not contain original data. Guest edited issues provide expert views on specific questions giving an extensive and comprehensive analysis of a specific field of activities in genomics. All aspects of genetic analysis and gene function will be covered, particularly in the growing areas of human genomics, functional genomics and next generation sequencing, molecular evolution, developmental biology, aging research and systems/statistical modeling.

iii) Opinion papers from internationally and widely recognized experts addressing contemporary questions and issues in the field of genome science and systems biology and basic and clinical research practices.

Following are the articles from the journal Current Genomics, 16 issue 1:

Article: Revise Engineering of Genome-wide Gene Regulatory Networks from Gene Expression Data   –

Author(s): Zhi-Ping Liu

Article: siRNA-directed DNA Methylation in Plants

Author(s): Meng Xie and Bin Yu

Article: Genes and Conditions Controlling Mammalian Pre- and Post-implantation Embryo Development

Author(s): G. Anifandis, C.I. Messini, K. Dafopoulos and I.E. Messinis

 

Article: Genetics and Vaccines in the Era of Personalized Medicine

Author(s): John Castiblanco and Juan-Manuel Anaya

Article: DNA Secondary Structure at Chromosomal Fragile Sites in Human Disease

Author(s): Ryan G. Thys, Christine E. Lehman, Levi C. T. Pierce and Yuh-Hwa Wang

For details, please visit: http://bit.ly/18JfbGo

Recently Published Issue Of the Journal Current Genomics

Current Genomics is a peer-reviewed journal that provides essential reading for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments in genome science and systems modeling.

Current Genomics publishes three types of peer-reviewed articles including:

1. i) High-qualityresearch papersreporting on new and original data generated at the genome scale level, including meta-analysis studies. Systems biology, molecular systems modeling, molecular evolution, developmental biology, aging research and human disease research are topics of particular interest. Position papers dealing with new or complex methodological approaches whether experimental or mathematical are greatly welcome in this section.
2. ii) Authoritative and comprehensivereviewsfrom widely-recognized experts, covering all the latest and outstanding developments in genome science and computational/systems biology. Proposals for mini-hot topics (2-3 review papers) and full hot topics (6-8 review papers) are welcome in this section and they should not contain original data. Guest edited issues provide expert views on specific questions giving an extensive and comprehensive analysis of a specific field of activities in genomics. All aspects of genetic analysis and gene function will be covered, particularly in the growing areas of human genomics, functional genomics and next generation sequencing, molecular evolution, developmental biology, aging research and systems/statistical modeling.

iii) Opinion papers from internationally and widely recognized experts addressing contemporary questions and issues in the field of genome science and systems biology and basic and clinical research practices.

Following are the articles from the journal Current Genomics, 16 Issue 1:

Article: Revise Engineering of Genome-wide Gene Regulatory Networks from Gene Expression Data   –

Author(s): Zhi-Ping Liu

Article: siRNA-directed DNA Methylation in Plants

Author(s): Meng Xie and Bin Yu

 

Article: Genes and Conditions Controlling Mammalian Pre- and Post-implantation Embryo Development

Author(s): G. Anifandis, C.I. Messini, K. Dafopoulos and I.E. Messinis

 

Article: Genetics and Vaccines in the Era of Personalized Medicine

Author(s): John Castiblanco and Juan-Manuel Anaya

 

Article: DNA Secondary Structure at Chromosomal Fragile Sites in Human Disease

Author(s): Ryan G. Thys, Christine E. Lehman, Levi C. T. Pierce and Yuh-Hwa Wang

 

For details, please visit: http://bit.ly/18JfbGo

 

 

Bentham Open Access Article

The article entitled “MicroRNAs: Important Epigenetic Regulators in Osteoarthritis,” in the journal Current Genomics, 2014, 15, 481-484, is now open for all to view and access.

For article Information, please visit: http://bit.ly/1K2ZZiW
For journal information, please visit: http://bit.ly/1zaGrGr