Highlighted article from the journal Current Organic Chemistry Vol 20 issue 9

COC-Articles_20-9

http://benthamscience.com/journals/current-organic-chemistry/

Highlighted article from the journal Current Genomics Vol 17 issue 4

CG-Articles_17-4

http://benthamscience.com/journals/current-genomics/

Highlighted article from the journal Current Cardiology Reviews Vol 12 issue 1

CCR-12-1-Articles

http://benthamscience.com/journals/current-cardiology-reviews/

Highlighted article from the journal Current Topics in Medicinal Chemistry Vol 16, Issue 16

CTMC-Articles_16-16

http://benthamscience.com/journals/current-topics-in-medicinal-chemistry/

Highlighted article from the journal Current Protein and Peptide Science

Isolation and Characterization of L-Tryptophan Ammonia Lyase from Rubrivivax benzoatilyticus Strain JA2

Author(s): Ranjith N. Kumavath, Ch.V. Ramana, Ch. Sasikala, Debmalya Barh, Alan Prem Kumar and Vasco Azevedo.

Abstract: Ammonia lyase belongs to the family of enzymes that catalyzes the deamination of amino acids. Depending on the relative activity towards the substrates, L-tryptophan ammonia lyase converts L-tryptophan to indole 3-acrylic acid and ammonia. Here, we isolated, purified, and characterized an L-tryptophan ammonia lyase from phototrophic purple non-sulfur bacterium Rubrivivax benzoatilyticus JA2. The isolated L-tryptophan ammonia lyase found to catalyze the reaction of L-tryptophan to produce indole 3-acrylic acid and NH3. The enzyme is a heterotetramer and has the highest affinity to L-tryptophan. The optimum pH and temperature for the enzymatic action were 7.5 and 35°C, respectively and the Km and Vmax were 40.4 ± 23.1 nM and 0.964±0.2046 s-1, respectively. These results suggest that the isolated enzyme is highly bioactive and could be a new class. Further molecular analyses are required to confirm the novelty of the enzyme.

CPPS-Articles_16-8

http://benthamscience.com/journals/current-protein-and-peptide-science/volume/16/issue/8/page/775/


 


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Highlighted Article Of the Journal Current Vascular Pharmacology

CVP-13-3-Mangge-Harald-Arti

For details, please visit: http://benthamscience.com/journal/index.php?journalID=cvp

Highlighted Article of the Journal Current Drug Metabolism

 

CMB-Articles_03-01-Piero-Lu
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