AIMS & SCOPE
Current HIV Research covers all the latest and outstanding developments of HIV research by publishing original research, full-length/mini review articles and guest edited thematic issues. The novel pioneering work in the basic and clinical fields on all areas of HIV research covers: virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and transmission, anti-retroviral therapy and adherence, drug discovery, the latest developments in HIV/AIDS vaccines and animal models, mechanisms and interactions with AIDS related diseases, social and public health issues related to HIV disease, and prevention of viral infection. Periodically, the journal invites guest editors to devote an issue on a particular area of HIV research of great interest that increases our understanding of the virus and its complex interaction with the host.
Articles from the Journal: Current HIV Research; Volume 18 Issue 2
FOR DETAILS ON THE ARTICLES, PLEASE VISIT HERE
Article by Disease on “HIV”
Background: It is well established that antiretroviral therapy (ART), while highly effective in controlling HIV replication, cannot eliminate virus from the body. Therefore, the majority of HIV-1-infected individuals remain at risk for developing AIDS due to persistence of infected reservoir cells serving as a source of virus re-emergence. Several reservoirs containing replication competent HIV-1 have been identified, most notably CD4+ T cells. Cells of the myeloid lineage, which are the first line of defense against pathogens and participate in HIV dissemination into sanctuary organs, also serve as cellular reservoirs of HIV-1. In latently infected resting CD4+ T cells, the integrated copies of proviral DNA remain in a dormant state, yet possess the ability to produce replication competent virus after cellular activation. Studies have demonstrated that modification of chromatin structure plays a role in establishing persistence, in part suggesting that latency is, controlled epigenetically.< p> Conclusion: Current efforts to eradicate HIV-1 from this cell population focus primarily on a “shock and kill” approach through cellular reactivation to trigger elimination of virus producing cells by cytolysis or host immune responses. However, studies revealed several limitations to this approach that require more investigation to assess its clinical application. Recent advances in gene editing technology prompted use of this approach for inactivating integrated proviral DNA in the genome of latently infected cells. This technology, which requires a detailed understanding of the viral genetics and robust delivery, may serve as a powerful strategy to eliminate the latent reservoir in the host leading to a sterile cure of AIDS.
Read more: http://benthamscience.com/journals/current-hiv-research/volume/14/issue/5/page/431/
HIV, Human Immunodeficiency Virus, has been the deadliest virus discovered in the last century. The virus is feared for its ability to affect the immune system of humans and render them vulnerable to catch any other virus, bacteria or disease that may be around. What’s worse is the contagious nature of HIV, as it can easily transmit through blood diffusion, sexual transmission, cuts and wounds, and also from mothers to babies. The virus has been extremely resistant to medicines and treatments so far, making it a veteran killer of humans.
There has been some recent advancement in administering drugs to HIV patients which have proven promising in keeping the virus from multiplying. Applauding this progress, the researchers have also apprehended that the virus is so resilient that it quickly alters itself through mutation to keep its onslaught going. The drugs can only hold the virus back temporarily and soon they lose their utility.
This has led the researchers to develop computational methods to track the changes occurring in HIV and realize when the right time to change the course of treatment comes. The method can also make the changes predictable and so the scientists will be able to proactively deal with the danger.
The research paper, Current Approaches in Computational Drug Resistance Prediction in HIV, published in Current HIV Research journal presents the study in detail.
HIV is among the most feared viruses that emerged in the last century. Feared it is, because it is complicated for the researchers, let alone the sufferers. Having thousands of brilliant minds working for years and publishing tons of researches in order to find clues to eradicating the HIV completely, the virus has still been very resilient to disappear.
Thus far the efforts have led to suppressing this demon only to see it lift it head again. But researchers at Institute for Virus Research, Kyoto University, Japan suggest that with the recent progresses in genome editing some stronger weapons have been developed now. Researchers, in the paper, Perspectives of Genome-Editing Technologies for HIV Therapy, have shown viable prospects for using tools like CRISPR/Cas9 to identify even the dormant HIV genomes in the battle.
The idea is that, if you can identify the hidden intruders in the cells you can certainly shoot them down better. This idea has a shining future if the research community keeps improving these very anti-HIV weapons.
Bentham Science wishes Prof. Charles Wood, a very Happy Birthday!!
We are thankful to him for the outstanding contribution in our journal “Current HIV Research”.