Podcast: Autoinflammation and Immunomodulation in Inflammatory Fibromyalgia Syndrome- A Review

Author(s): Samy Metyas*, Tamer Rezk, Daniel Arkfeld, Thomas Leptich.

For article details, visit: http://www.eurekaselect.com/145618

Subscribe our YouTube channelhttp://bit.ly/1lr0czy

Testimonial by Maite Sylla-Iyarreta Veitia!

Print

Contributed Article: “Update on COX-2 Selective Inhibitors: Chemical Classification, Side Effects and their Use in Cancers and Neuronal Diseases

TESTIMONIAL BY LOUIS LTEIF!

Louis Lteif-2.jpg

Contributed Article: “The Role of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Cardiovascular Homeostasis: A Non-Systematic Literature Review

 

TESTIMONIAL BY ESSA HARIRI!

Essa Hariri

Contributed Article: “The Role of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Cardiovascular Homeostasis: A Non-Systematic Literature Review

TESTIMONIAL BY DIMA A. SABBAH!

Dima A. Sabbah

Contributed Article: “The Role of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Cardiovascular Homeostasis: A Non-Systematic Literature Review

Testimonial by Mathieu Nadeau-Vallée!

Mathieu Nadeau-Vallée

Contributed Article: “Preterm Birth and Neonatal Injuries: Importance of Interleukin-1 and Potential of Interleukin-1 Receptor Antagonists

Most Accessed Article – Regulatory Role of Heat Shock Proteins in the Pathogenesis of Type 1 and Type 2 Diabetes – Current Immunology Reviews

Journal: Current Immunology Reviews

Author(s): Christiane Habich, Henrike Sell, Volker Burkart

Graphical Abstract:

Abstract:

Diabetes is a severe metabolic disorder characterized by hyperglycemia due to defects in insulin secretion and/or insulin action. Over the past decades, a continuous rise of the incidence of diabetes is observed, leading to epidemic dimensions of the disease in large parts of the western world. Depending on the type of diabetes, (auto-)immune processes (type 1 diabetes) or metabolic disorders (type 2 diabetes) dominate the pathogenesis of the disease. Therefore, investigations aiming at the identification of disease mechanisms and the development of preventive and therapeutic approaches, focus on the identification of common regulators of both immunologic and metabolic pathways involved in the pathogenesis of diabetes. So far, extensive research, employing clinical and experimental approaches demonstrate a central role of heat shock proteins (HSPs) in diabetes development. In type 1 diabetes intracellular HSPs located in the beta cell can provide efficient protection against the deleterious effects of autoimmune effector mechanisms whereas extracellular HSPs can stimulate the release of beta cell damaging mediators from innate immune cells or even contribute to the induction of immune reactivity against beta cell specific antigens. In type 2 diabetes HSPs are involved in the control of various immunologic and metabolic processes contributing to the induction and maintenance of low-grade, subclinical inflammation associated with the development of diabetes and related disorders such obesity and insulin resistance. The results of current research on the pathogenesis of diabetes point to HSPs and HSP-dependent immunologic and metabolic pathways as promising targets for strategies to prevent or cure diabetes and its sequelae.

 

To access the article, please visit: http://www.eurekaselect.com/152952

 

 

Highlighted Article – Fertility Drugs and Ovarian Cancer – Current Cancer Drug Targets

CCDT- Articles_17-9-Aus Tariq Ali.jpg

To access this article, please visit: http://www.eurekaselect.com/153449

 

Editor’s Choice – Model Validity in Nanoimmunosafety: Advantages and Disadvantages of In vivo vs In vitro Models, and Human vs Animal Models – Current Bionanotechnology

Journal: Current Bionanotechnology

Author(s): Diana Boraschi, Paola Italiani.

Graphical Abstract:

 

Abstract:

The thorough understanding of the interaction between nanomaterials and the immune system is the starting point both for nanomaterial exploitation in nanomedicine and for the implementation of an effective regulatory framework concerning nanosafety for human health and the environment. In this context, the use of valid models, in vitro and in vivo, is central for assessing both the positive and the detrimental effects of nanomaterials, thereby predicting their possible risks for human and environmental health. Thus, predicting models are sought that allow us on one side defining hazard posed by nanomaterials, and therefore implementing safety regulation and safe-by-design nanotechnologies, and on the other side exploiting nanomaterials for more effective therapeutic and preventive medical strategies. Here, we consider the advantages and limitation of the current in vitro and in vivo human and animal models, and the appropriateness of their use for assessing the effects of nanomaterials on immunity.

Read more here: http://www.eurekaselect.com/142770

Testimonial by Ali Ganji!

Ali Ganji

Contributed Article: “IL-27: Friend Or Foe in the Autoimmune Diseases