New Issue :: Letters in Organic Chemistry 15, Issue 7

Letters in Organic Chemistry publishes original letters, mini-reviews and guest edited issue in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts.

The journal is an essential reading for all organic chemists belonging to both academia and industry.

Articles from the journal Letters in Organic Chemistry Volume 15, Issue 7:

For details on the articles, please visit this link :: https://bit.ly/2l8o7O7

 

EDITOR’S CHOICE – An Efficient Gram Scale Synthesis of Aryl Iodides from Aryl Diazofluoroborates in Water under Mild Conditions

Journal: Letters in Organic Chemistry

Author(s): Somnath S. Gholap

Graphical Abstract:

Abstract:

Transition metal-free synthesis of synthetically valuable aryl iodides from aryl diazofluroborates in water under mild conditions has been described. Majority of synthesized aryl iodides are obtained in quantitative yields (>99 %) under present reaction conditions. The structural effects due to the substituents present on aryl diazofluoroborates did not show any satisfactory effect on the yields of the aryl iodides. Hence, the methodology presented here was found to be adventitious for the quantitative production of synthetically valuable aryl iodides.

 

Read more here: http://www.eurekaselect.com/155407/article

 

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RIA

EDITOR’S CHOICE – Divergent Synthesis of Novel Dienylbenzothiazoles and Arylidenedibenzoxazepines and Evaluation of Their Antiproliferative and Cytotoxic Properties – LETTERS IN ORGANIC CHEMISTRY

Journal: Letters in Organic Chemistry

Author(s): P.R. Kathiravan*, S. Muthukumaran, N. Dhatchanamoorthy, T. Shanmuganathan, M. Venugopal

Graphical Abstract:

 

Abstract:

Background: Dibenzo-oxazepine and Benzothiazole derivatives are used as antipsychotics, anticancer, antibacterial and anti-inflammatory agents.

Methods: Arylidene derivatives of 1,2,3,4-Tetrahydro-Dibenzo[b,f][1,4]Oxazepine and 2-[2-Chloro- Cyclohex-1-enyl]- Benzothiazoles were synthesized by reacting benzylidene derivative of chloroaldehyde with 2-aminophenol and 2-aminothiophenol respectively. Benzylidene derivative of chloroaldehyde was prepared by Vilsmeier reaction of 2-benzylidenecyclohexanone derivatives, which were obtained from the condensation of various aromatic aldehydes with cyclohexanone.

Results: Benzylidene derivatives of 1,2,3,4-Tetrahydro-Dibenzo[b,f][1,4]Oxazepine 6a-g exhibited promising antiproliferative activity with GI50 values in the micromolar range. The compounds containing halo, alkyl and alkoxyl groups as substituents on the benzylidine ring have been found to be very effective cytotoxic agents.

Conclusion: This study identified dibenzo-oxapine as a prospective pharmacophore which set the stage for thorough exploration of this compound class as cytotoxic agents.

Read more here: http://www.eurekaselect.com/153003/article

 

 

EDITOR’S CHOICE – New Prolinamides with Isosteviol Skeleton as Efficient Organocatalysts for the Direct Asymmetric Aldol Reaction – Letters in Organic Chemistry

Journal: Letters in Organic Chemistry

Author(s): Yu-Xia Liu*, Zhi-Wei Ma, Yan-Xun Li, Jing-Chao Tao

Graphical Abstract:

 

Abstract:

In this work, two new prolinamides with isosteviol skeleton were synthesized and used as chiral catalysts for the asymmetric aldol reaction. Solvent effects, catalyst loading, substrate scope and the influence of water on the reaction were investigated. With only 5 mol % loading, the synthesized catalysts showed excellent activity (up to 98% yield) and good stereoselectivity (up to 87:13 dr, 90% ee) for the direct aldol reaction of cyclohexanone and substituted benzaldehydes at room temperature.

Read more here: http://www.eurekaselect.com/158630/article

 

 

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WISHING A VERY HAPPY BIRTHDAY TO PROF. GWILHERM EVANO!

Prof. Gwilherm Evano.jpg

PROF. GWILHERM EVANO

EDITOR-IN-CHIEF: Letters in Organic Chemistry

Free University of Brussels
Brussels
Belgium

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TESTIMONIAL BY LEE SUAN CHUA!

Lee Suan Chua

Contributed Article: “The Extent of Hydroxymethylfurfural Formation in Honey by Heating Temperature and Duration