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Current Cancer Drug Targets 18 – 1

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Letters in Organic Chemistry  15 – 1

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Cardiovascular & Hematological Disorders-Drug Targets 17-2

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WISHING A VERY HAPPY BIRTHDAY TO PROF. GWILHERM EVANO!

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PROF. GWILHERM EVANO

EDITOR-IN-CHIEF: Letters in Organic Chemistry

Free University of Brussels
Brussels
Belgium

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Letters in Organic Chemistry 14-10

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TESTIMONIAL BY LEE SUAN CHUA!

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Contributed Article: “The Extent of Hydroxymethylfurfural Formation in Honey by Heating Temperature and Duration

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Testimonial by Ahmed Reza Massah!

Ahmad Reza Massah

Contributed Article: “Synthesis of Some Novel Sulfonamide-Imines as Potential Antimicrobial Agents

Testimonial by Ahmad Reza Massah!

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Contributed Article: “Synthesis of Some Novel Sulfonamide-Imines As Potential Antimicrobial Agents

Highlighted Article – Oxidation of Aldehydes and Alcohols to Carboxylic Acids Using NaCIO Under Microwave Irradiation or Classical Heating Without a Catalyst – Letters in Organic Chemistry

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Testimonial by Md Yousuf Ansari!

Md Yousuf Ansari

Contributed Article: “Synthesis, Cytotoxic Evaluation And Molecular Docking Studies of New Oxadiazole Analogues

Press Release for EurekAlert! Synthesis of internal gem-diborylalkanes by copper-catalyzed double hydroboration

This research article by Dr. Yuma Netsu et al has been published in Letters in Organic Chemistry, Volume 14, Issue 4, 2017

Graphical Abstract:

 

Geminal organometallic reagents have attracted considerable attention due to their unique activity. Among them, gem-diboryl compounds are particularly valuable due to their stability, no-toxicity, and usability for a variety of transformations.

Despite the usefulness of the gem-diborylalkanes as synthetic reagents, effective methods for the synthesis of the gem-diborylalknaes have been still limited. Double hydroboration is a convenient and useful method because the reaction does not need unstable reagents such as diazo compounds or unusual directing groups, which are necessary for other synthetic methods. However, the double hydroboration has been applied mainly to terminal alkynes. In the reaction of internal alkynes, it is difficult to control the regioselectivity. Furthermore, 1,2-diboryl compounds can be obtained as side products if the regioselectivities of the first and the second hydroboration are opposite.

In this paper, the authors report the synthesis of internal geminal diboryl compounds by copper-catalyzed double hydroboration of internal alkynes bearing carbonyl groups. The regioselectivities of two hydroboration reactions can be perfectly restricted by the carbonyl groups. Although the second hydroboration is much slower by steric repulsion, the issue can be solved by an appropriate choice of ligands.

For more information about the article, please visit http://www.eurekaselect.com/151056