RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

Recent Patents on Engineering 12-1

https://bit.ly/2IiaAwI

Current Molecular Medicine 17-7

https://bit.ly/2GMmy4B

Letters in Organic Chemistry 15-4

https://bit.ly/2uED8yO

Letters in Drug Design & Discovery 15-4

https://bit.ly/2Ec5XSJ

Current Pharmaceutical Biotechnology 18-12

https://bit.ly/2GIVVxH

RIA

EDITOR’S CHOICE – Divergent Synthesis of Novel Dienylbenzothiazoles and Arylidenedibenzoxazepines and Evaluation of Their Antiproliferative and Cytotoxic Properties – LETTERS IN ORGANIC CHEMISTRY

Journal: Letters in Organic Chemistry

Author(s): P.R. Kathiravan*, S. Muthukumaran, N. Dhatchanamoorthy, T. Shanmuganathan, M. Venugopal

Graphical Abstract:

 

Abstract:

Background: Dibenzo-oxazepine and Benzothiazole derivatives are used as antipsychotics, anticancer, antibacterial and anti-inflammatory agents.

Methods: Arylidene derivatives of 1,2,3,4-Tetrahydro-Dibenzo[b,f][1,4]Oxazepine and 2-[2-Chloro- Cyclohex-1-enyl]- Benzothiazoles were synthesized by reacting benzylidene derivative of chloroaldehyde with 2-aminophenol and 2-aminothiophenol respectively. Benzylidene derivative of chloroaldehyde was prepared by Vilsmeier reaction of 2-benzylidenecyclohexanone derivatives, which were obtained from the condensation of various aromatic aldehydes with cyclohexanone.

Results: Benzylidene derivatives of 1,2,3,4-Tetrahydro-Dibenzo[b,f][1,4]Oxazepine 6a-g exhibited promising antiproliferative activity with GI50 values in the micromolar range. The compounds containing halo, alkyl and alkoxyl groups as substituents on the benzylidine ring have been found to be very effective cytotoxic agents.

Conclusion: This study identified dibenzo-oxapine as a prospective pharmacophore which set the stage for thorough exploration of this compound class as cytotoxic agents.

Read more here: http://www.eurekaselect.com/153003/article

 

 

EDITOR’S CHOICE – New Prolinamides with Isosteviol Skeleton as Efficient Organocatalysts for the Direct Asymmetric Aldol Reaction – Letters in Organic Chemistry

Journal: Letters in Organic Chemistry

Author(s): Yu-Xia Liu*, Zhi-Wei Ma, Yan-Xun Li, Jing-Chao Tao

Graphical Abstract:

 

Abstract:

In this work, two new prolinamides with isosteviol skeleton were synthesized and used as chiral catalysts for the asymmetric aldol reaction. Solvent effects, catalyst loading, substrate scope and the influence of water on the reaction were investigated. With only 5 mol % loading, the synthesized catalysts showed excellent activity (up to 98% yield) and good stereoselectivity (up to 87:13 dr, 90% ee) for the direct aldol reaction of cyclohexanone and substituted benzaldehydes at room temperature.

Read more here: http://www.eurekaselect.com/158630/article

 

 

RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

Medicinal Chemistry Volume 14, Issue 2
http://bit.ly/2ESFuxH

Clinical Immunology, Endocrine & Metabolic Drugs Volume 4, Issue 1
http://bit.ly/2FhuhVc

Anti-Cancer Agents in Medicinal Chemistry Volume 17, Issue 14
http://bit.ly/2Ca5K5H

Letters in Organic Chemistry Volume 15, Issue 3
http://bit.ly/2BG12fa

Current Molecular Medicine Volume 17, Issue 6
http://bit.ly/2ofkAiZ

Protein & Peptide Letters Volume 24, Issue 12
http://bit.ly/2CxVmk9

recent-issues

RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

Current Physical Chemistry 7 – 4

http://bit.ly/2BGhH2z

MicroRNA 6 – 3

http://bit.ly/2APY58r

Current Molecular Medicine 17 – 4

http://bit.ly/2kdMd9Z

Mini-Reviews in Medicinal Chemistry 18 – 1

http://bit.ly/2CXqTxp

Current Cancer Drug Targets 18 – 1

http://bit.ly/2jdhhpF

Letters in Organic Chemistry  15 – 1

http://bit.ly/2oAE3Nz

Current Pharmaceutical Analysis 14 – 1

http://bit.ly/2CUJl9R

Current Green Chemistry 4 – 2

http://bit.ly/2BCKZyT

Endocrine, Metabolic & Immune Disorders – Drug Targets 18 – 1

http://bit.ly/2BsTxGf

Cardiovascular & Hematological Disorders-Drug Targets 17-2

http://bit.ly/2ySrih3

recent-issues

WISHING A VERY HAPPY BIRTHDAY TO PROF. GWILHERM EVANO!

Prof. Gwilherm Evano.jpg

PROF. GWILHERM EVANO

EDITOR-IN-CHIEF: Letters in Organic Chemistry

Free University of Brussels
Brussels
Belgium

RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

Recent Patents on Mechanical Engineering 10-3

http://bit.ly/2knILJ8

Letters in Drug Design & Discovery 14-12

http://bit.ly/2l1EsHw

Current Topics in Medicinal Chemistry 17-27

http://bit.ly/2B68pw9

Recent Innovations in Chemical Engineering 10-1

http://bit.ly/2B8ffRD

Current Stem Cell Research & Therapy 12-8

http://bit.ly/2yhlgGF

Current Organic Chemistry 21-21

http://bit.ly/2Adezr0

Current Pharmaceutical Design 23-28

http://bit.ly/2yhksS3

Letters in Organic Chemistry 14-10

http://bit.ly/2Aw82vy

recent-issues

TESTIMONIAL BY LEE SUAN CHUA!

Lee Suan Chua

Contributed Article: “The Extent of Hydroxymethylfurfural Formation in Honey by Heating Temperature and Duration

RECENTLY PUBLISHED ISSUES – BENTHAM SCIENCE JOURNALS

Current Genomics  18-6

http://bit.ly/2ALJWc1

Letters in Organic Chemistry 14-9

http://bit.ly/2A3NE4x

Anti-Cancer Agents in Medicinal Chemistry 17-10

http://bit.ly/2z7DC2k

Recent Patents on Anti-Infective Drug Discovery 12-1

http://bit.ly/2zO2FUQ

Current Organic Chemistry 21-18

http://bit.ly/2imER31

Letters in Drug Design & Discovery 14-11

http://bit.ly/2j0qgdc

Current Pharmaceutical Design 23-26

http://bit.ly/2il5XYk

recent-issues

 

Testimonial by Ahmed Reza Massah!

Ahmad Reza Massah

Contributed Article: “Synthesis of Some Novel Sulfonamide-Imines as Potential Antimicrobial Agents