Testimonial by Ahmad Reza Massah!

Ahmad Reza Massah.jpg

Contributed Article: “Synthesis of Some Novel Sulfonamide-Imines As Potential Antimicrobial Agents

Highlighted Article – Oxidation of Aldehydes and Alcohols to Carboxylic Acids Using NaCIO Under Microwave Irradiation or Classical Heating Without a Catalyst – Letters in Organic Chemistry

LOC-Articles_14-10-Maria Pujol

http://benthamscience.com/journals/letters-in-organic-chemistry/

Testimonial by Md Yousuf Ansari!

Md Yousuf Ansari

Contributed Article: “Synthesis, Cytotoxic Evaluation And Molecular Docking Studies of New Oxadiazole Analogues

Press Release for EurekAlert! Synthesis of internal gem-diborylalkanes by copper-catalyzed double hydroboration

This research article by Dr. Yuma Netsu et al has been published in Letters in Organic Chemistry, Volume 14, Issue 4, 2017

Graphical Abstract:

 

Geminal organometallic reagents have attracted considerable attention due to their unique activity. Among them, gem-diboryl compounds are particularly valuable due to their stability, no-toxicity, and usability for a variety of transformations.

Despite the usefulness of the gem-diborylalkanes as synthetic reagents, effective methods for the synthesis of the gem-diborylalknaes have been still limited. Double hydroboration is a convenient and useful method because the reaction does not need unstable reagents such as diazo compounds or unusual directing groups, which are necessary for other synthetic methods. However, the double hydroboration has been applied mainly to terminal alkynes. In the reaction of internal alkynes, it is difficult to control the regioselectivity. Furthermore, 1,2-diboryl compounds can be obtained as side products if the regioselectivities of the first and the second hydroboration are opposite.

In this paper, the authors report the synthesis of internal geminal diboryl compounds by copper-catalyzed double hydroboration of internal alkynes bearing carbonyl groups. The regioselectivities of two hydroboration reactions can be perfectly restricted by the carbonyl groups. Although the second hydroboration is much slower by steric repulsion, the issue can be solved by an appropriate choice of ligands.

For more information about the article, please visit http://www.eurekaselect.com/151056

Testimonial by Li De Zhang!

Task PPD 05v4

Contributed Article: Dehydrobruceine C, A New Quassinoid from the Seeds of Brucea javanica

Highlighted Article Flyer for the journal “Letters in Organic Chemistry”

Dr Rafik Gatri

http://www.eurekaselect.com/148826

New Issue :: Letters in Organic Chemistry 14, Issue 2

Letters in Organic Chemistry publishes original letters, mini-reviews and guest edited issue in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts.

The journal is an essential reading for all organic chemists belonging to both academia and industry.

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Articles from the journal Letters in Organic Chemistry 14, Issue 2:

   For details on the articles, please visit this link :: http://bit.ly/2oDoe44

Highlighted Article Flyer for the journal “Letters in Organic Chemistry”

LOC-Articles_13-10-Vivek Srivastava

 

http://benthamscience.com/journals/letters-in-organic-chemistry/

Editor’s Choice – “Novel Fluorescent Benzimidazoles: Synthesis, Characterization, Crystal Structure and Evaluation of Their Anticancer Properties”

Journal: Letters in Organic Chemistry

Author(s):  Yeong Keng Yoon, Tze Shyang Chia, Ching Kheng Quah, Wan Leng Lim, Chuan Wei Oo, Amir Nasrolahi Shirazi, Keykavous Parang,Tan Soo Choon

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Abstract:

Background: The benzimidazole core structure is an interesting platform for drug discovery since it possess a wide spectrum of pharmacological activities such as antiviral, anti-inflammatory and anticancer. Previously the antiproliferative effect of novel substituted benzimidazole derivative was demonstrated based on the ethyl 1-(2-hydroxyethyl)-2-phenyl-1H-benzo[d]imidazole-5-carboxylate scaffold through the inhibition of sirtuin activity. This work aimed to further explore the previous work for identifying novel fluorescent benzimidazoles which possess anti proliferative activities based on the reported scaffold.

Methods: Compounds were synthesized based on a multistep but facile protocol. Structure of the compounds was elucidated using NMR, FT-IR, LC-MS, elemental analysis and unambiguously confirmed through crystal X-ray diffraction. Molar extinction coefficient of the autofluorescence compounds were determined using UV spectroscopy while cancer cell growth inhibitory activity was carried out using MTS assay.

Results: Four novel benzimidazole derivatives were successfully synthesized in this study. All four compounds were found to emit blue fluorescence when light-irradiated with molar extinction coefficient ranging from 21000 to 29000 (mol L-1)-1cm-1. Two of the synthesized compounds showed good anti proliferative activity against four cancer cell lines tested in this study.

Conclusion: Four novel benzimidazole derivatives presented in this study were synthesized using multistep protocol starting from 4-fluoro-3-nitrobenzoic acid. Their structures have been elucidated using multiple techniques such as NMR, FT-IR, LC-MS, elemental analysis and X-ray crystallography where possible. They were found to have high autofluorescence and two of them were able to inhibit the growth of cancer cells tested in this study.

Read more here: http://www.eurekaselect.com/147990

New Issue :: Letters in Organic Chemistry 13, Issue 9

Letters in Organic Chemistry publishes original letters, mini-reviews and guest edited issue in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts.

The journal is an essential reading for all organic chemists belonging to both academia and industry.

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Articles from the journal Letters in Organic Chemistry 13, Issue 9:

For details on the articles, please visit this link :: http://bit.ly/2iUN5Ra