Bentham Science Free Trial in Poznan University of Technology (Politechnika Poznanska) | Free Trial ends on August 11th, 2020

 

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It is our pleasure to inform you that Bentham Science Publishers has activated a 3 month trial subscription for Poznan University of Technology (Politechnika Poznanska). The trial subscription covers access to Bentham Science journals and Books content.

Bentham Science uses the platforms Eurekaselect (our proprietary platform) & Ingenta Connect (a well-known content gateway) for offering journal and Books trials. The trial has been activated on both platforms, Eureka & Ingenta. (Note: Book trials are only available on Eurekaselect)

Members of your library can view all Bentham Science journal issues (2000-2020) in full text and eBook content which will allow your library users to access our catalog of over 800 eBooks for the same duration via the following URLs:

1.  https://eurekaselect.net

2. http://www.ingentaconnect.com/content/ben

Trial Duration:  3 Months
Start Date: 16th May, 2020
End Date: 31st Aug, 2020

Online Trial Access Procedure:

To access the free trial offer, you do not need to insert a user ID or a password. Instead you can access the following URL by logging through the library’s registered IP Addresses in your browser:

Ingenta Connect: http://www.ingentaconnect.com/content/ben

Eureka Select:
For journals: https://eurekaselect.net/bypublication 
For eBooks https://eurekaselect.net/bybook

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If you require further assistance, please contact us at: hermain@benthamscience.net CC: faizan@benthamscience.net

Bentham Science Free Trial in Shri Guru Ram Rai Institute Of Medical & Health Sciences | Free Trial ends on August 11th, 2020

 

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It is our pleasure to inform you that Bentham Science Publishers has activated a 3 month trial subscription for Shri Guru Ram Rai Institute Of Medical & Health Sciences. The trial subscription covers access to Bentham Science journals and Books content.

Bentham Science uses the platforms Eurekaselect (our proprietary platform) & Ingenta Connect (a well-known content gateway) for offering journal and Books trials. The trial has been activated on both platforms, Eureka & Ingenta. (Note: Book trials are only available on Eurekaselect)

Members of your library can view all Bentham Science journal issues (2000-2020) in full text and eBook content which will allow your library users to access our catalog of over 800 eBooks for the same duration via the following URLs:

1.  https://eurekaselect.net

2. http://www.ingentaconnect.com/content/ben

Trial Duration:  3 Months
Start Date: May 11th, 2020
End Date: August 11th, 2020

Online Trial Access Procedure:

To access the free trial offer, you do not need to insert a user ID or a password. Instead you can access the following URL by logging through the library’s registered IP Addresses in your browser:

Ingenta Connect: http://www.ingentaconnect.com/content/ben

Eureka Select:
For journals: https://eurekaselect.net/bypublication 
For eBooks https://eurekaselect.net/bybook

Free Trial Announcement Among The Users Of Your Library/Institution

We will appreciate it if you could announce the availability of this free trial to all the members of your library/institution. By alerting your members, maximum people would be able to benefit from access to our top class scientific content.

 

If you require further assistance, please contact us at: hermain@benthamscience.net CC: faizan@benthamscience.net

Bentham Science Free Trial in Technical University of Gdansk | Free Trial ends on June 20th, 2020

 

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It is our pleasure to inform you that Bentham Science Publishers has activated a 3 month trial subscription for Technical University of Gdansk. The trial subscription covers access to Bentham Science journals and Books content.

Bentham Science uses the platforms Eurekaselect (our proprietary platform) & Ingenta Connect (a well-known content gateway) for offering journal and Books trials. The trial has been activated on both platforms, Eureka & Ingenta. (Note: Book trials are only available on Eurekaselect)

Members of your library can view all Bentham Science journal issues (2000-2020) in full text and ebook content which will allow your library users to access our catalog of over 800 eBooks for the same duration via the following URLs:

1.  https://eurekaselect.net

2. http://www.ingentaconnect.com/content/ben

Trial Duration:  3 Months
Start Date: March 20th, 2020
End Date: June 20th, 2020

 

Online Trial Access Procedure:

To access the free trial offer, you do not need to insert a user ID or a password. Instead you can access the following URL by logging through the library’s registered IP Addresses in your browser:

Ingenta Connect: http://www.ingentaconnect.com/content/ben

Eureka Select:
For journals: https://eurekaselect.net/bypublication 
For eBooks https://eurekaselect.net/bybook

 

Free Trial Announcement Among The Users Of Your Library/Institution

We will appreciate it if you could announce the availability of this free trial to all the members of your library/institution. By alerting your members, maximum people would be able to benefit from access to our top class scientific content.

If you require further assistance, please contact us at: hermain@benthamscience.net CC: faizan@benthamscience.net

Bentham Science Free Trial in Kyushu University Medical Library | Free Trial ends on 16th June, 2020

 

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It is our pleasure to inform you that Bentham Science Publishers has activated a 3 month trial subscription for Kyushu University Medical Library. The trial subscription covers access to Bentham Science journals and Books content.

Bentham Science uses the platforms Eurekaselect (our proprietary platform) & Ingenta Connect (a well-known content gateway) for offering journal and Books trials. The trial has been activated on both platforms, Eureka & Ingenta. (Note: Book trials are only available on Eurekaselect)

Members of your library can view all Bentham Science journal issues (2000-2020) in full text and ebook content which will allow your library users to access our catalog of over 800 eBooks for the same duration via the following URLs:

1.  https://eurekaselect.net

2. http://www.ingentaconnect.com/content/ben

Trial Duration:  3 Months
Start Date: March 16th, 2020
End Date: 16th June, 2020

Online Trial Access Procedure:

To access the free trial offer, you do not need to insert a user ID or a password. Instead you can access the following URL by logging through the library’s registered IP Addresses in your browser:

Ingenta Connect: http://www.ingentaconnect.com/content/ben

Eureka Select:
For journals: https://eurekaselect.net/bypublication 
For eBooks https://eurekaselect.net/bybook

Free Trial Announcement Among The Users Of Your Library/Institution

We will appreciate it if you could announce the availability of this free trial to all the members of your library/institution. By alerting your members, maximum people would be able to benefit from access to our top class scientific content.

If you require further assistance, please contact us at: hermain@benthamscience.net CC: faizan@benthamscience.net

Bentham Science Free Trial in Bursa Uludag University | Free Trial ends on May 18th, 2020

 

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It is our pleasure to inform you that Bentham Science Publishers has activated a 3 month trial subscription for Bursa Uludag University. The trial subscription covers access to Bentham Science journal content.

Bentham Science uses the platform; Eurekaselect (our proprietary platform) for offering journal trials. The trial has been activated on Eureka

Members of your library can view all Bentham Science journal issues (2000-2019) in full text, via the following URL: www.eurekaselect.com

Online Trial Access Procedure:

To access the free trial offer, you do not need to insert a user ID or a password. Instead you can access the following URL by logging through the library’s registered IP Addresses in your browser:

Eureka Select: http://www.eurekaselect.com/bypublication

Free Trial Announcement Among The Users Of Your Library/Institution

We will appreciate it if you could announce the availability of this free trial to all the members of your library/institution. By alerting your members, maximum people would be able to benefit from access to our top class scientific content.

If you require further assistance, please contact us at: hermain@benthamscience.net CC: faizan@benthamscience.net

Bentham Science Free Trial in Abbvie | Free Trial ends on 19th May, 2020

FREE-TRIAL

 

It is our pleasure to inform you that Bentham Science Publishers has activated a 3 month trial subscription for AbbVie. The trial subscription covers access to Bentham Science journals and Books content.

Bentham Science uses the platforms Eurekaselect (our proprietary platform) & Ingenta Connect (a well-known content gateway) for offering journal and Books trials. The trial has been activated on both platforms, Eureka & Ingenta. (Note: Book trials are only available on Eurekaselect)

Members of your library can view all Bentham Science journal issues (2000-2020) in full text and ebook content which will allow your library users to access our catalog of over 800 eBooks for the same duration via the following URLs:

1.  https://eurekaselect.net

2. http://www.ingentaconnect.com/content/ben

Trial Duration:  3 Months
Start Date: 19th Feb, 2020
End Date: 19th May, 2020

 

Online Trial Access Procedure:

To access the free trial offer, you do not need to insert a user ID or a password. Instead you can access the following URL by logging through the library’s registered IP Addresses in your browser:

Ingenta Connect: http://www.ingentaconnect.com/content/ben

Eureka Select:
For journals: https://eurekaselect.net/bypublication 
For eBooks https://eurekaselect.net/bybook

 

Free Trial Announcement Among The Users Of Your Library/Institution

We will appreciate it if you could announce the availability of this free trial to all the members of your library/institution. By alerting your members, maximum people would be able to benefit from access to our top class scientific content.

If you require further assistance, please contact us at: hermain@benthamscience.net CC: faizan@benthamscience.net

Bentham Science Free Trial in Sardar Patel University| Free Trial ends on March 10th, 2020

 

1

 

It is our pleasure to inform you that Bentham Science Publishers has activated a 1 month trial subscription for Sardar Patel University. The trial subscription covers access to Bentham Science journal content.

Bentham Science uses the platform; Eurekaselect (our proprietary platform) for offering journal trials. The trial has been activated on Eureka

Members of your library can view all Bentham Science journal issues (2000-2019) in full text, via the following URL: www.eurekaselect.com

Online Trial Access Procedure:

To access the free trial offer, you do not need to insert a user ID or a password. Instead you can access the following URL by logging through the library’s registered IP Addresses in your browser:

Eureka Select: http://www.eurekaselect.com/bypublication

Free Trial Announcement Among The Users Of Your Library/Institution

We will appreciate it if you could announce the availability of this free trial to all the members of your library/institution. By alerting your members, maximum people would be able to benefit from access to our top class scientific content.

If you require further assistance, please contact us at: hermain@benthamscience.net CC: faizan@benthamscience.net

Bentham Science Free Trial in Institute of Physical Chemistry | Free Trial ends on 2nd December, 2019

 

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It is our pleasure to inform you that Bentham Science Publishers has activated a 3 month trial subscription for Institute of Physical Chemistry. The trial subscription covers access to Bentham Science journal content.

Bentham Science uses the platform; Eurekaselect (our proprietary platform) for offering journal trials. The trial has been activated on Eureka

Members of your library can view all Bentham Science journal issues (2000-2019) in full text, via the following URL: www.eurekaselect.com

Online Trial Access Procedure:

To access the free trial offer, you do not need to insert a user ID or a password. Instead you can access the following URL by logging through the library’s registered IP Addresses in your browser:

Eureka Select: http://www.eurekaselect.com/bypublication

Free Trial Announcement Among The Users Of Your Library/Institution

We will appreciate it if you could announce the availability of this free trial to all the members of your library/institution. By alerting your members, maximum people would be able to benefit from access to our top class scientific content.

If you require further assistance, please contact us at: hermain@benthamscience.net CC: faizan@benthamscience.net

Hepatitis day related article

Design and Synthesis of Amino Acid Tethered Thiazolones to Screen for Hepatitis C NS5B Polymerase Inhibitors

 

Journal Name: Letters in Drug Design & Discovery

Author(s): Yili Ding*, Kenneth L. Smith, Chamakura V.N.S. Varaprasad.

 

 

Graphical Abstract:

 

Abstract:

Background: Hepatitis C Virus (HCV) infection is one of the causes for liver cirrhosis and hepatocellular carcinoma leading to liver failure. An estimated 2-3% of the world population is chronically infected with HCV. HCV is a positive single stranded RNA virus encoding for a single polypeptide, which cleaves into structural and non-structural proteins. The non-structural (NS) proteins play critical roles in viral replication and have become the targets for HCV chemotherapy. The current treatment involves pegylated interferon-α/ribavirin-based treatment and a combination of direct-acting antivirals. NS5B is a critical enzyme for the replication of HCV RNA and is an interesting target for the screening and design of small molecule inhibitors to interfere in the HCV viral replication.

Methods: Screening of a library of compounds in a replicon assay, a thiazolone derivative was identified as a NS5B enzyme inhibitor (IC50: 11 µM). Based on the structure of this lead compound, few libraries of compounds were designed and synthesized following a fragment based approach. Structural features of both peptide-based and non-peptide-based protease inhibitors such as lopinavir and tipranavir were considered while designing novel compounds.

Results: Several novel protease inhibitors were designed and synthesized based on the structural fragments of lopinavir and tipranavir. This resulted in identification of compounds with thiazolone scaffold as having good anti-HCV NS5B enzyme activity.

However, to improve their cellular activity, the thiazolone scaffold was then tethered with several amino acids and then screened for their anti-HCV activity which led to finding a tethered thiazolone as novel hepatitis C NS5B polymerase inhibitor with good cellular potency (EC50 = 1.2 µM).

Conclusion: Systematic modification of lead compound (EC50 = 35 µM) from an enzyme assay and by tethering with a suitable amino acid improved the cellular potency of the lead compound. This resulted in a compound 18c with nearly 30 fold (EC50 = 1.2 µM) potent compound in cellular assay than the original lead compound. It’s believed that this improvement was possible because of better transport of the active compound into the cell due to its amino acid tether.

 

For more detail, please visit: http://www.eurekaselect.com/152214

Bentham Science Publishers 3 Months Free Trial Is Active In:

Eawag (Lib4RI – Library for the Research Institutes) Switzerland

Lib4RI is the “Library for the Research Institutes within the ETH domain: Eawag, Empa, PSI & WSL”. As a scientific library, we provide all affiliates of the 4 research institutes with literature and technical information, both electronic and printed, for research, teaching and consulting.

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