Most Accessed Articles | Dysfunctional Mechanism of Liver Cancer Mediated by Transcription Factor and Non-coding RNA

Journal Name: Current Bioinformatics

Author(s): Wei Zeng, Fang Wang, Yu Ma, Xianchun Liang, Ping Chen*.

 

 

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Background: There have been numerous experiments and studies on liver cancer by biomedical scientists, while no comprehensive and systematic exploration has yet been conducted. Therefore, this study aimed to systematically dissect the transcriptional and non-coding RNAmediated mechanisms of liver cancer dysfunction.

Method: At first, we collected 974 liver cancer associated genes from the Online Mendelian Inheritance in Man (OMIM). Afterwards, their interactors were recruited from STRING database so as to identify 18 co-expression modules in liver cancer patient expression profile. Crosstalk analysis showed the interactive relationship between these modules. In addition, core drivers for modules were identified, including 111 transcription factors (STAT3, JUN and NFKB1, etc.) and 1492 ncRNAs (FENDRR and miR-340-5p, etc.) Read out full article here: http://www.eurekaselect.com/167479

Saffron-based crocin prevents liver cancer: Preclinical studies and beyond!!

Biomolecule of the golden spice is good for your liver

saffron

Liver cancer remains among the leading causes of cancer-related death worldwide. New study lead by UAE University Prof. Amr Amin unravels mechanisms by which saffron-based ‘crocin’ protects against liver cancer. The study entitled Saffron-Based Crocin Prevents Early Lesions of Liver Cancer: In Vivo, In Vitro and Network Analyses is funded by Al-Jalila Foundation & Terry Fox Foundation and is published in Recent Patents on Anticancer Drug Discovery. Using murine model, human liver cancer cells, gene expression profiling and computer-assisted modeling analyses, Amin’s study identifies NF-kB as a regulatory hub and a candidate therapeutic drug target for liver cancer.

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