Infographic on World Malaria Day

malaria

ARTICLE TO READ ON World Malaria Day

Malaria in Children – Prevention and Management

Author(s): Angela Dramowski, Lisa Frigati, Helena Rabie, Mark Cotton

Abstract:

Malaria causes a quarter of all childhood deaths in Sub-Saharan Africa. Considerable gains in global malaria control have been achieved in the last decade but coverage of effective interventions remains low in areas of greatest malaria burden. Some countries have achieved reduced malaria related mortality through application of recent advances in malaria prevention and treatment of children. Artemisinin combination therapies (particularly artesunate) are highly efficacious and well-tolerated in children, although several alternative treatments are available. However, the evolution of drug resistance (including emerging resistance to artemisinin derivatives) threatens the success of malaria treatment programmes. This special issue review is aimed at paediatric clinicians in resource-poor settings and provides a summary of recent data from paediatric trials of malaria treatment and prevention interventions.

Read more here: http://www.eurekaselect.com/118494/article

 

EDITOR’S CHOICE – Neoflavonoids as Prospective Compounds Against Parasitic Neglected Tropical Infections and Human Immunodeficiency Virus – Current Bioactive Compounds

Journal: Current Bioactive Compounds 

Author(s): Gláucio B. Saldanha, George L.S. Oliveira, José C.C.L. da Silva, Maria C.P. Oliveira, Ana P.S.C.L. da Silva*, Juceni P. de Lima David

Graphical Abstract:

 

Abstract:

Background: Neoflavonoids comprise a group of compounds that have a C6-C3-C6 carbon skeleton and that naturally occur in higher plants from families Clusiaceae, Leguminosae, Rubiaceae, Passifloraceae, Asteraceae and Rutaceae.

Objective: Neoflavonoids have drawn great interest lately due to their pharmacological and biochemical properties found in vitro and in vivo studies, which is attributed to the pattern of substitutions found in their basic chemical structure.

Methods: This review was prepared by analyzing articles selected from Science Direct, Scopus, Pub Med, Web of Science and SciFinder.
Results: Among other pharmacological activities, in vitro and in vivo studies have highlighted these compounds as promising bioactive molecules in the treatment of some parasitic neglected tropical infections (NTIs) such as malaria, leishmaniasis and American trypanosomiasis (Chagas Disease). Neoflavonoids have also showed activity against HIV-1 (human immunodeficiency virus type 1), and have been used to develop new molecules for the treatment of HIV/AIDS.
Conclusion: Therefore, a more intensive research of neoflavonoids can provide inputs to discover and develop alternative therapies from new bioactive molecules. Thus, this review summarizes the results of studies involving neoflavonoids and their derivatives with therapeutic implications in the treatment of NTIs and HIV.

Article by Disease – “Clinico-Hematological Features and Management Outcome in Neonatal Malaria: A Nine Years Analysis from North India”

Article by Disease on “Pediatrics and Neonatology”

6

Abstract:

Background: Malaria is an important cause of death and illness in children worldwide. Most cases of neonatal malaria are misdiagnosed because of lack of specific symptoms and general lack of awareness. Nothing much is known in literature about the hematological changes during malaria infection and outcome of disease in neonates. Neonatal malaria is an underdiagnosed entity. So this hospital based observational study aims to assess diagnostic features of neonatal malaria.

Methods: From August 2004 to August 2013, information of all slide positive for malaria cases aged 0 to 28 days admitted to our pediatric hospital was collected and analysed.Results: 28 slide positive cases of neonatal malaria were studied, four out of them were congenital malaria. Fever (93%) was the most common symptom followed by pallor (72%) and diarrhoea (50%). We also found respiratory distress in four (14%) cases. Apart from anemia and atypical lymphocytosis, We also found thrombocytopenia and low hematocrit, MCV and RBC count. Two cases with bleeding manifestations expired during course of treatment.Discussion: Malaria in the first few months of life can simulate transplacentally or postnatally acquired infection such as TORCH, syphilis, neonatal hepatitis and septicemia all having an important symptom complex of fever jaundice, hepatosplenomegaly and anemia. Although in our cases clinical presentation has been similar to septicemia but culture of blood, CSF and urine were sterile. The dilemma of distinguishing neonatal malaria alone versus neonatal sepsis or both existing does not seem to be easily resolved by the use of clinical features alone. The laboratory diagnosis of parasitemia in neonates require special attention in Giemsa staining as well as the technical skill involved in malaria microscopy because parasite densities are low. So high degree of suspicion is needed to diagnose malaria in newborns presenting with fever and anemia.

Read more: http://benthamscience.com/journals/current-pediatric-reviews/volume/12/issue/4/page/286/

World Malaria Day 2016!

“Hybrid Drugs for Malaria”

Abstract: Malaria continues to devastate much of the tropics and sub-tropics in spite of the availability of a number of antimalarial drugs. Part of this problem is due to the disadvantages of the drugs in use, which include (depending on the drug) side effects, reduced efficacy due to resistance, and high cost. Multiple traditional and novel approaches to the discovery and design of new antimalarial agents are likely to be required to furnish the new drugs necessary for improved malaria control. This review will address one novel and emerging approach, namely the development of hybrid antimalarial agents composed of two distinct antimalarial moieties joined covalently. Particular emphasis will be placed on the properties of the hybrids design, including biological activity, advantages over other approaches, and the potential to address issues relating to resistance, solubility and formulation/delivery. The review will discuss the synthetic methodology used to form the hybrid and the ease by which it may be cleaved to form the independent components in vivo. 

Read more here: http://benthamscience.com/journals/current-pharmaceutical-design/article/69929/

Recent Issues of Bentham Science Journals have been Published

Inflammation & Allergy-Drug Targets, 13 Issue 4

Aims & scope

Inflammation & #Allergy – Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in inflammation and allergy e.g. disease specific proteins, receptors, enzymes, genes. The journal publishes expert in-depth reviews, original research articles, drug clinical trial studies and guest edited thematic issues covering a range of current topics on drug targets involved in inflammation and allergy. As the discovery, identification, characterization and validation of novel human drug targets for anti-inflammation and allergy drug discovery continue to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.

http://www.eurekaselect.com/124592/issue/4

Abstracted & Indexed in

Chemical Abstracts, BIOSIS, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, MEDLINE/Index Medicus, EMBASE/ExcerptaMedica, Scopus, PubsHub, GenamicsJournalSeek, MediaFinder®-Standard Periodical Directory, and J-Gate..

For details about the latest issues, visit:http://benthamscience.com/journal/index.php?journalID=iadt

 

Current Topics in Medicinal Chemistry, 14 Issue 14

Aims & scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

http://www.eurekaselect.com/124602/issue/14

Abstracted & Indexed in

BIOSIS, Chemical Abstracts, MEDLINE/Index Medicus, PUBMED, ISI, Science Citation Index ExpandedTM, Biochemistry & Biophysics Citation IndexTM, index to Scientific Reviews®, Current Contents®, EMBASE/ExcerptaMedica, Journal Citation Reports/Science Edition, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, Scopus, GenamicsJournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, and J-Gate.

For details about the latest issues, visit:http://benthamscience.com/journal/index.php?journalID=ctmc

 

Mini-Reviews in Organic Chemistry, 11 Issue 3

Aims & scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

http://www.eurekaselect.com/124555/issue/3

Abstracted & Indexed in

BIOSIS, Chemical Abstracts, MEDLINE/Index Medicus, PUBMED, ISI, Science Citation Index ExpandedTM, Biochemistry & Biophysics Citation IndexTM, index to Scientific Reviews®, Current Contents®, EMBASE/ExcerptaMedica, Journal Citation Reports/Science Edition, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, Scopus, GenamicsJournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, and J-Gate

For details about the latest issues, visit:http://benthamscience.com/journal/index.php?journalID=ctmc

 

Current Inorganic Chemistry, 4 Issue 2

Aims & scope

Current Inorganic #Chemistry, a peer-reviewed journal, publishing original research, review articles and guest edited thematic issues in all areas of inorganic chemistry. The journal’s scope includes the synthesis, crystal structure, physical methods, thermodynamics, reactivity, spectroscopy, electronic and bonding properties of significant new and known (bio) inorganic and organometallic compounds.

Current Inorganic Chemistry is an important and reliable source of information on current developments, research and theory in the field. The emphasis is on publishing high quality articles.

http://www.eurekaselect.com/124573/issue/2

Abstracted & Indexed in

Chemical Abstracts, MediaFinder®-Standard Periodical Directory, and J-Gate.

For details about the latest issues, visit: http://benthamscience.com/journal/index.php?journalID=cic

 

Current Drug Targets, 15 Issue 10

Aims & scope

Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes.

Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication mini- & full-length review articles and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

http://www.eurekaselect.com/124609/issue/10

Abstracted & Indexed in

#ChemicalAbstracts, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, Science Citation Index Expanded® (Sci Search), Index to Scientific Reviews®, Biochemistry & Biophysics Citation Index®, PUBMED, BIOSIS, Journal Citation Reports/Science Edition, EMBASE/ExcerptaMedica, MediaFinder-Standard Periodical Directory, Medline, Scopus, EMBASE, Genamics Journal Seek, PubsHub, and J-Gate.

For details about the latest issues, visit: http://benthamscience.com/journal/index.php?journalID=cdt

 

Current Molecular Imaging, 3 Issue 1

Aims & scope

Current Molecular Imaging publishes peer reviewed expert review articles and special topic issues on all aspects of experimental and clinical research in molecular imaging. Topics include the investigative and practical applications of novel radiopharmaceuticals; standard and complicated imaging methodologies and probes; as well as standard and evolving quantitative approaches.

http://www.eurekaselect.com/124654/issue/1

Abstracted & Indexed in

Chemical Abstracts, J-Gate, PubsHub, and Scopus.

For details about the latest issues, visit: http://benthamscience.com/journal/index.php?journalID=cmi

 

Recent Patents on Anti-Infective Drug Discovery, 9 Issue 1

Aims & scope

Recent Patents on Anti-Infective Drug Discovery publishes review and research articles, drug clinical trial studies and guest edited thematic issues on recent patents in the field of anti-infective drug discovery e.g. on novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery. The journal also covers recent research (where patents have been registered) in fast emerging therapeutic areas/targets & therapeutic agents related to anti-infective drug discovery.

http://www.eurekaselect.com/124637/issue/1

Abstracted & Indexed in

PubMed/Medline, Scopus, EMBASE, METADEX, CAB Abstracts, Cambridge Scientific Abstracts (CSA), Chemical Abstracts, GenamicsJournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, and J-Gate.

For details about the latest issues, visit:http://benthamscience.com/journal/index.php?journalID=rpaidd

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