Kudos Article – Discovery of natural anti-cancerous therapeutic molecules that target topoisomerases

Swati Singh, Veda P. Pandey, Kusum Yadav, Anurag Yadav, U. N. Dwivedi

DOI: 10.2174/1389203721666200918152511

What is it about?

Thus, the present review describes the anticancer potential of plant-derived secondary metabolites belonging to alkaloids, flavonoids and terpenoids directed against topoisomerases. Furthermore, in view of the recent advances made in the field of computer-aided drug design, the present review also discusses the use of computational approaches such as ADMET, molecular docking, molecular dynamics simulation and QSAR to assess and predict the safety, efficacy, potency and identification of these potent anti-cancerous therapeutic molecules.

Why is it important?

Cancer is the second leading cause of global deaths of millions of people. Some of the bottlenecks in the successful development of anticancer drugs include the absence of cancer specificity, toxicity and the development of multi-drug resistance among cancerous cells. Since ancient times, plant-derived products are being used as therapeutic agents against several diseases. The development of cancer prevention and healthcare products from natural products has a broader prospect, greater economic and social benefits compared with prevalent synthetic anticancerous drugs. Read now: https://bit.ly/3qvkwv3

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Journal Name: Current Drug Metabolism

Contributed Article: Interaction between Traditional Chinese Medicine and Anticoagulant/Antiplatelet Drugs

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