CALL FOR PAPERS | Thematic Issue for Current Alzheimer Research

Journal: Current Alzheimer Research

Guest Editor(s): Keshen Li
Tentative Publication Date: July, 2019

 

Systems Genetics of Alzheimer’s disease: From GWAS to
Disease Pathways

 

Alzheimer’s disease (AD) is the most common dementia and neurodegenerative disease in the elderly. AD is highly heritable and complex. In recent years, genetic studies especially genomewide association studies (GWAS) and next-generation sequencing have identified several AD risk variants and pathways associated with the potential pathogenesis and genetic mechanisms of AD. Until now, more than 20 risk loci that affect AD have been identified. These loci are estimated to explain about 28% of the heritability of liability, 30% of familial risk, and over 50% of sibling recurrence risk of developing AD. Despite these successes, the majority of genetic risk remains to be further identified. The identification of the causative variants or mutations remains challenging and the molecular mechanisms are still rarely characterized. In the post-genome era, the major challenge is to mine novel disease risks from multi-level omics data using system biology methods, which may expand our knowledge of the causes of AD. Therefore, we propose a Special Issue of the topic ‘Systems genetics of Alzheimer’s disease: From GWAS to disease
pathways’. This special issue will focus on the mechanism of genesis and development of AD, as well as valuable clues for the development of novel therapeutic approaches of AD. We believe the systems genetics will help us move from disease risk loci to disease aetiology. This Special Issue welcomes reviews and original papers covering recent genetic research on AD using system biology methods. For more details please visit: https://bit.ly/2M2i6mo

 

Email here to submit your paper: hermain@benthamscience.net

                                                          CC: faizan@benthamscience.net

CURRENT ALZHEIMER RESEARCH

CALL FOR PAPERS | Thematic Issue for Current Medicinal Chemistry

Journal: Current Alzheimer Research

Guest Editor(s): Keshen Li
Tentative Publication Date: July, 2019

 

Systems Genetics of Alzheimer’s disease: From GWAS to
Disease Pathways

 

Alzheimer’s disease (AD) is the most common dementia and neurodegenerative disease in the elderly. AD is highly heritable and complex. In recent years, genetic studies especially genomewide association studies (GWAS) and next-generation sequencing have identified several AD risk variants and pathways associated with the potential pathogenesis and genetic mechanisms of AD. Until now, more than 20 risk loci that affect AD have been identified. These loci are estimated to explain about 28% of the heritability of liability, 30% of familial risk, and over 50% of sibling recurrence risk of developing AD. Despite these successes, the majority of genetic risk remains to be further identified. The identification of the causative variants or mutations remains challenging and the molecular mechanisms are still rarely characterized. In the post-genome era, the major challenge is to mine novel disease risks from multi-level omics data using system biology methods, which may expand our knowledge of the causes of AD. Therefore, we propose a Special Issue of the topic ‘Systems genetics of Alzheimer’s disease: From GWAS to disease
pathways’. This special issue will focus on the mechanism of genesis and development of AD, as well as valuable clues for the development of novel therapeutic approaches of AD. We believe the systems genetics will help us move from disease risk loci to disease aetiology. This Special Issue welcomes reviews and original papers covering recent genetic research on AD using system biology methods. For more details please visit: https://bit.ly/2M2i6mo

Email here to submit your paper: hermain@benthamscience.net

                                                          CC: faizan@benthamscience.net

CURRENT ALZHEIMER RESEARCH

Most Accessed Article – Discovery of Putative Halogenases in Environmental Samples Using Meta- genomics – Current Biotechnology

Journal: Current Biotechnology

Author(s): Özlem Erol, Isabel W.C.E. Arends, Gerard Muyzer.

Graphical Abstract:

Abstract:

Background: Halogenases are involved in the halogenation of secondary metabolites with pharmaceutical relevance, such as the antibiotics chloramphenicol and vancomycin. Hereby flavin- or FADH2-dependent halogenases represents the major class of halogenases. Previous investigations on flavin-dependent halogenases have focused on Actinomycetes and sponge-associated microorganisms. In order to extend our knowledge on the diversity and distribution of halogenases we have applied a PCR-based screening approach to show the wide distribution of flavin-dependent halogenases in metagenomes of microbial communities from different environments, such as soils and sediments.

Methods: For the screening of new flavin-dependent halogenases a metagenomic approach was used. Metagenomic libraries were constructed and screened by homology-driven PCR based on degenerate primers designed from known flavin-dependent halogenases.

Results: We screened 55 environmental samples that we collected from different habitats by a PCRbased screening for novel flavin-dependent halogenases. The phylogenetic analysis of the putative halogenases together with the 16S Amplicon sequencing results of the environmental samples demonstrates the wide distribution of the halogenases and the large sequence diversity. In addition, metagenomic libraries were constructed to screen for flavin-dependent halogenases.

Conclusion: The metagenomic approach described in this paper is a promising method to explore novel putative halogenases from different environments.

To access the article, please visit: http://www.eurekaselect.com/145933 

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