Aims & Scope – Current Microwave Chemistry

Volume 9, 3 Issues, 2022
ISSN: 2213-3364 (Online)
ISSN: 2213-3356 (Print)

Current Microwave Chemistry is an international peer-reviewed journal that publishes important contributions describing advances in the use of the microwave in the fields of chemistry, biology, medicine, biomedical science, and engineering. The journal covers microwave-assisted synthesis of novel organic, organometallic and inorganic molecules or complexes, kinetics and mechanistic studies of microwave-induced chemical reactions and potential use of microwave irradiation in the fields of drug discovery, green chemistry, catalysis and industrial process development. It is the premier source of microwave related information for chemists, biologists, pharmacologists and engineers in both industry and academia. Read Now: http://bit.ly/2kmlQSs

TESTIMONIAL BY PADMAJA G!

Padmaja G

Contributed Article: “Optimization of Microwave-Assisted Dilute Acid Pretreatment for Enhanced Structural Breakdown and Enzymatic Saccharification of Lignocellulo-Starch Biomass

Press Release – Microwave-assisted iodine-catalyzed rapid synthesis of 6H-indolo[2,3-b]quinolines

This article by Dr. Bimal K. Banik et al. is published in Current Microwave Chemistry, Volume 4, 2017

 

Indoloquinoline alkaloids have received significant popularity because of their antimalarial and DNA intercalating properties as well as their use as folk medicines for the control of fever, amoebiasis and malaria. Related metabolites include cryptotackieine and norcryptotackieine which are linear indolo[2,3-b]quinoline alkaloids. These molecules have demonstrated numerous medicinal activities including antimicrobial, and cytotoxicity. They act through DNA intercalation and inhibition of topoisomerase II inhibition. Consequently, organic and medicinal chemists and biologists have become interested in their concise preparation and studies of their biological activities. A few synthetic routes have been developed for the preparation of these structurally unique and complex indole heterocycles. Interestingly, most of these available methods are one-pot methods. For example, high temperature reaction of molecular iodine-catalyzed reaction in diphenyl ether, pivalic acid and ruthenium-exchanged FAU-Y zeolite in 1,4-dioxane is performed. N-Bromosuccinimide at room temperature is found to be good for this purpose. The principal limitation is that almost all of these methods require a very long time. Moreover, the yields of the target molecules are low.

The current research is aimed to develop an efficient synthetic method for the synthesis of indoloquinoline alkaloids mentioned above. Considering the known procedures and analyzing the conditions of the experiments, the iodine-catalyzed tandem method is proved to be excellent. Despite the superiority of iodine, this method produces products with low to moderate yields, requires long reaction time and high temperature. Therefore, an improvement of molecular iodine-catalyzed reaction for this purpose is necessary.

Our research group has been exploring microwave-induced reactions for more than 25 years. Reactions conducted under microwave oven are known to be rapid and successful at much less drastic conditions. Moreover, they also produce the target molecules in better yields without giving side reactions in most of the examples. In conventional methods, unwanted side reactions in many instances lower the yields of the products or produce mixture of products and therefore, isolation of the desired compounds become tedious. On the basis of several successes on microwave-induced chemistry and our interests in the preparation of medicinally useful compounds, we have investigated the preparation of cryptotackieine and norcryptotackieine and their derivatives in automated microwave oven in tightly sealed reaction container.

Indole-3-carboxyaldehyde and two equivalents of aniline in presence of 10 mol% of molecular iodine at 600C and 300 watt power in a sealed vessel are irradiated in an automated microwave. It is interesting to note that the reaction proceeds rapidly with an increase in the yield of the product compared to the conventional heating (oil bath or heating mantle) at much higher temperature. The structure of the starting reactants and products suggests a most probable mechanism. Dehydration to imine from aldehyde and amine, nucleophilic reaction of the imine, annulation and subsequent aromatization occurs in a tandem process in a one-pot method.

This method is extended for the preparation of 6H-indolo[2,3-b]quinolines. As expected, the previously known compounds are synthesized very rapidly and with simple work-up, and without extensive purification. No solvent is used when one of the reactants is liquid or oil. These reactions are also performed in the presence of solvents (THF, MeOH, CHCl3, and CH2Cl2). THF and MeOH are proved to be the best solvent whereas CHCl3 and CH2Cl2 are moderately good for this method.

An expeditious simple and rapid microwave-assisted procedure for the synthesis of significant types of indoloquinolines using molecular iodine as catalyst in a one-pot is developed. The procedure described herein is the first rapid method for the synthesis of novel indoloquinolines. The rate acceleration by microwave-induced method is probably due to the alteration of the transition state of the series of reactions that occur in this tandem process. The benefit of this process is the lowered energy consumption compared to traditional method under reflux or high temperature that requires input of latent heat of vaporization. In this method, vaporization is not possible and so little expenditure of latent heat occurs. The non-ionizing radiation of the microwave is absorbed very efficiently by the reactants and polar solvents and thereby accelerates the process in an unbelievable way.

For more information about the article, please visit: http://www.eurekaselect.com/151565/article

Highlighted Article – Oxidation of Aldehydes and Alcohols to Carboxylic Acids Using NaCIO Under Microwave Irradiation or Classical Heating Without a Catalyst – Letters in Organic Chemistry

LOC-Articles_14-10-Maria Pujol

http://benthamscience.com/journals/letters-in-organic-chemistry/

Podcast by Dr. Dibakar C. Deka on ‘An Improved Method for the Synthesis of β-Aminocarbonyl… Microwave Irradiation’

 An Improved Method for the Synthesis of β-Aminocarbonyl and β-Aminonitrile Compounds using Indium (III) Trifluoromethanesulphonate in Glycerol under Microwave Irradiation

by

Author(s): Monmi Saikia, Dibakar C. Deka and Sanjeeb Karmakar.

More on the article ::: http://bit.ly/1MvRRHW

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Recent issue of the Journal Current Microwave Chemistry

Recent issue of the Journal Current Microwave Chemistry has been published

Current Microwave Chemistry, Issue 1-2

Aims & Scope

Current Microwave Chemistry is an international peer-reviewed journal that publishes important contributions describing advances in the use of the microwave across the field of in chemistry, biology, medicine, biomedical science, and engineering. The journal covers microwave-assisted synthesis of novel organic, organometallic and inorganic molecules or complexes, kinetics and mechanistic studies of microwave-induced chemical reactions and potential use of microwave irradiation in the fields of drug discovery, green chemistry, catalysis and industrial process development. It is the premier source of microwave related information for chemists, biologists, pharmacologists and engineers in both industry and academia.

http://www.benthamscience.com/journal/index.php?journalID=cmic#top

Abstracted & Indexed in:

Chemical Abstracts Service (CAS).

For more details please visit: http://benthamscience.com/journal/index.php?journalID=cmic

Bentham Science Launches “Current Microwave Chemistry”

News release date: May 27, 2014

Bentham Science Publishers is proud to announce the launch of a new journal, Current Microwave Chemistry in May 2014. The inaugural journal issue is available online for free access via: http://benthamscience.com/journal/contents.php?journalID=cmic&issueID=122246

The journal covers microwave-assisted synthesis of novel organic, organometallic and inorganic molecules or complexes, kinetics and mechanistic studies of microwave-induced chemical reactions and potential use of microwave irradiation in the fields of drug discovery, green chemistry, catalysis and industrial process development. It is the premier source of microwave related information for chemists, biologists, pharmacologists and engineers in both industry and academia. The journal is available in both electronic and print editions.

For more details on this new journal, visit the website: Current Microwave Chemistry

Scholarly Publications by BSP’s Indian Author’s in the Journal, Current Organic Chemistry

Image1. L-Proline Catalysed Domino Reactions for the Synthesis of Heterocycles

Author(s): Sethuraman Indumathi, Jose C. Menendez and Subbu Perumal

Affiliation: Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625021, India.

Abstract

L-Proline is a cheap, water-soluble organocatalyst that is able to induce the synthesis of a large number of heterocyclic systems. This work is reviewed, with emphasis on the literature of the 2005-2011 period. The domino reactions have been classified according to the nature of the first step of their proposed mechanisms, as follows: (i) iminium-initiated domino mechanisms; (ii) enamineinitiated domino mechanisms; (iii) reactions proceeding via the intermediacy of dienamines; (iv) reactions in which proline acts as a Lewis base and (v) L-proline/metal catalysed reactions.

 

2. Multicomponent 1,3-Dipolar Cycloaddition Reactions in the Construction of Hybrid Spiroheterocycles

Author(s): Natarajan Arumugam, Raju Suresh Kumar, Abdulrahman I. Almansour and Subbu Perumal

Affiliation: Department of Chemistry, College of Science, King Saud University, PO Box 2455, Riyadh, Saudi Arabia; and Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamilnadu, India.

Abstract

Spiroheterocyclic ring systems are attractive synthetic targets due to their interesting conformational features and their structural implications on their activity in biological systems. Consequently, a vast deal of research by synthetic organic as well as medicinal chemists pertains to the synthesis of these heterocycles employing diverse synthetic methodologies. Among them, one-pot multicomponent 1,3-cycloaddition reactions have emerged as preferred synthetic protocol in view of their convergence, atom economy, ecofriendliness, flexibility and facile automation. This review article focuses on the assembly of mono-, di- and multispiro heterocyclic hybrids via aforesaid synthetic methodologies with a variety of dipolarophiles.

 

3. Microwave Assisted Organic Synthesis: Cross Coupling and Multicomponent Reactions

Author(s): Amit Kumar Gupta, Neetu Singh and Krishna Nand Singh

Affiliation: Department of Chemistry, Centre of Advanced Study, Banaras Hindu University, Varanasi-221005, India.

Abstract

Impact of microwave radiation on organic chemistry has been assessed by workers time to time. This review covers selected recent examples form cross-coupling reactions, multicomponent reactions along with some cycloaddition reactions to reveal the impact of microwave on organic synthesis.

 

4. Applications of Ultrasound in Organic Synthesis – A Green Approach

Author(s): Saurabh Puri, Balbir Kaur, Anupama Parmar and Harish Kumar

Affiliation: Department of Chemistry, Sant Longowal Institute of Engineering & Technology, Longowal-148106 (Pb.), India.

Abstract

Ultrasound irradiation differs from conventional energy sources (such as heat, light, or ionizing radiation) in time, pressure, and energy per molecule. The use of ultrasound waves in organic synthesis has attracted an increasing interest over the last years. Use of ultrasound waves as alternative source of energy is of great interest in the area of green and pharmaceutical chemistry. This review will focus on the uses of ultrasound waves in heterocyclic chemistry, condensation reactions, substitution reactions, oxidation, reduction, addition reactions, photochemical reactions, protection/deprotection reactions, coupling reaction photochemical reactions, polymerization reactions etc

 

5. Renewable Energy via Photocatalysis

Author(s): Ravikrishnan Vinu and Giridhar Madras

Affiliation: Department of Chemical Engineering, Indian Institute of Science, Bangalore 560012, India

Abstract

The generation of renewable energy through photocatalysis is an attractive option to utilize the abundantly available solar radiation for a sustainable future. Photocatalysis refers to charge-carrier, i.e. electron and hole, mediated reactions occurring on a semiconductor surface in presence of ultraviolet or visible light radiation. Photocatalysis is a well established advanced oxidation technique for the decontamination of toxic organic pollutants to CO2 and H2O. However, the generation of energy in the form of hydrogen, hydrocarbon fuels and electricity via photocatalysis is an upcoming field with great many technical challenges towards practical implementation. This review will describe the fundamental reaction mechanism of (i) photocatalytic water splitting, (ii) photocatalytic H2 generation in presence of different sacrificial agents, (iii) H2 and electricity generation in a photofuel cell, (iv) photocatalytic reduction of CO2 to hydrocarbons and useful chemicals, and (v) photocatalytic water-gas shift reaction. A historic and recent perspective of the above conversion techniques, especially with regard to the development of TiO2-based and non-TiO2 materials is provided. The activity of different materials for the above reactions based on quantifiers like reaction rate, quantum yield and incident-photon-to-current efficiency is compared, and key design considerations of the “best” photocatalyst or photoelectrode is outlined. An overall assessment of the research area indicates that the presently achieved quantum efficiencies for the above reactions are rather moderate in the visible region, and the goal is to develop a catalyst that absorbs visible radiation, provides good charge-carrier separation, and exhibits high stability for long periods of usage.

 

6. Non-Metathetic Behaviour of Olefin Metathesis Catalysts

Author(s): Sambasivarao Kotha, Shilpi Misra, Gaddamedi Sreevani and Bandarugattu V. Babu

Affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India.

Abstract

We describe various non-matathetic reactions catalyzed by metathesis catalysts. These examples include: isomerization of olefins, dehydrogenative oxidation, dihydroxylation, allylic alcohol to methyl ketone conversion, dimerization, vinylation of acetylenes, hydrosilylation, Kharasch addition, cyclopropanation, cycloisomerization, hydrogenation, deprotection of N- or O-allyl groups, [2+2+2] cyclotrimerization, [3+2] and [4+2] cycloaddition reactions. These advances indicate that metathesis catalysts have potential to generate new strategies other than the metathesis based methodologies.

 

7. Pyrrole: Chemical Synthesis, Microwave Assisted Synthesis, Reactions and Applications: A Review

Author(s): Shrinivas D. Joshi, Uttam A. More, Venkatrao H. Kulkarni and Tejraj M. Aminabhavi

Affiliation: Department of Pharmaceutical Chemistry, S. E. T’s College of Pharmacy, S. R. Nagar, Dharwad 580 002, Karnataka, India.

Abstract

Pyrrole is one of the main five membered heterocyclic systems reported for its various chemotherapeutic activities. Subsequently, pyrroles have been highlighted as the important biologically active scaffolds. This review focuses on the synthesis, reactions and pharmacological activity associated with pyrroles, and its derivatives. Microwave-assisted reactions are also covered to understand green chemistry aspects of pyrrole and its derivatives. Various pharmacological applications are discussed critically to assess the importance of the compounds.

 

8. Aromaticity in Polyacenes and Their Structural Analogues

Author(s): Ranjita Das, Arindam Chakraborty, Sudip Pan and Pratim K. Chattaraj

Affiliation: Department of Chemistry and Center for Theoretical Studies, Indian Institute of Technology Kharagpur, 721302, India.

Abstract

The successful synthesis of different polyacenes including theoretical assessment on the stability of larger acenes are discussed. The existence of favorable aromaticity criterion in polyacenes is understood in terms of different aromaticity indicators like nucleus independent chemical shift (NICS), harmonic oscillator model of aromaticity (HOMA), bond resonance energy (BRE). Clar’s Π- sextet rule is also very much effective in explaining their aromaticity. By virtue of low HOMO-LUMO gap, the probable application of polyacenes in the field of organic electronics is also highlighted. The polyacene analogues of inorganic ring compounds, viz., BN-acenes, CN-acenes, BO-acenes, BS-acenes, AlN-acenes and of alkali ring compounds, viz., Na-acenes and K-acenes also have polyacene-like aromaticity although in few cases the origin of aromaticity and qualitative nature of aromaticity differ significantly.

 
For details on the journal, please visit: Current Organic Chemistry
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