Author(s): Seon Woong Kim, Taeho Lee, Joo-Youn Lee, Sanghee Kim, Hee-Sook Jun, Eun-Young Park*, Dong Jae Baek*.
PF-543 has been known as a substance that strongly inhibits SK1. However, it also exhibits antineoplastic activity that is lower than other inhibitors of SK1. In this study, we compared PF-543 and synthesized a newly designed derivative of PF-543 (compound 2) in which two aromatic structures were connected in para-form. The synthesized derivative showed inhibitory effect on SK1, similar to that of PF-543. However, it was more cytotoxic to HT29, AGS, and PC3 cells than PF-543. We also carried out a docking study for SK1 and demonstrated that the synthesized derivative showed interaction with SK1 similar to PF-543. Results obtained from this study suggest that the structure of compound 2 may be well substituted for the structure of PF-543 in terms of biological activity, providing us important structural information for the design of new derivatives of PF-543. Read out full article here: http://www.eurekaselect.com/166082
Author(s): Prabhpreet Kaur*, Gurvinder Singh, Parminder Kaur.
This paper attempts to identify suitable Machine Learning (ML) approach for image denoising of radiology based medical application. The Identification of ML approach is based on (i) Review of ML approach for denoising (ii) Review of suitable Medical Denoising approach.
The review focuses on six application of radiology: Medical Ultrasound (US) for fetus development, US Computer Aided Diagnosis (CAD) and detection for breast, skin lesions, brain tumor MRI diagnosis, X-Ray for chest analysis, Breast cancer using MRI imaging. This survey identifies the ML approach with better accuracy for medical diagnosis by radiologists. The image denoising approaches further includes basic filtering techniques, wavelet medical denoising, curvelet and optimization techniques. In most of the applications, the machine learning performance is better than the conventional image denoising techniques. For fast and computational results the radiologists are using the machine learning methods on MRI, US, X-Ray and Skin lesion images. The characteristics and contributions of different ML approaches are considered in this paper. Read out full article here: http://www.eurekaselect.com/152027
Author(s): Maryam Norouzbahari, Emine V. Burgaz, Tugba Ercetin, Amirhossein Fallah, Alireza Foroumadi, Loghman Firoozpour, Mustafa F. Sahin, Mustafa Gazi, Hayrettin O. Gulcan*.
Considering the limitations of current cholinesterase inhibitor drugs for the treatment of Alzheimer’s disease, there is ongoing research activities to find out alternative drug candidates. The aryl-spacer-N-benzyl pharmacophore model has been effectively utilized to design various types of cholinesterase inhibitor molecules, including donepezil. Within this research study, we have questioned the significance of the benzyl group within this pharmacophore employing the urolithin derivatives. Urolithins are benzo[c]chromene analogue metabolites of ellagitannins, abundantly found in pomegranate and berry fruits. Read out full article here: http://www.eurekaselect.com/159057
Author(s): Zolaikha Rasouli, Raouf Ghavami*.
Iodide (I-) is a vital micronutrient and its essential roles have been approved in a number of neurological activities. Therefore, there is a growing interest in developing reliable sensitive quantitative methodologies for the determination of the amount of I- in edible salt samples.
First, 2heDTC was synthesized by the mixing of equivalent amounts of pure C2H7NO and CS2 in the presence of NH4OH under vigorous stirring in an ice bath. Then, AuNPs were synthesized; the 250 mL of 1 mM HAuCl4 was put into a round-bottomed flask and was boiled vigorously by stirring for 20 min. Then, 25 mL of 38.8 mM of Na3C6H5O7 was added rapidly into this solution. The solution was heated under reflux for another 15 min. The modification of the AuNPs surface was performed with 2heDTC by proceeding with the ligand exchange reaction. To the quantification of I-, 2 µL (1mM) Hg2+ was added to 0.5 mL (50 mM) of PBS solution with pH = 5.0 containing 500 µL of 2heDTC-AuNPs, which was then maintained at optimized time for the creation of bare AuNPs. Then, the different concentrations of I- were separately added. Finally, the surface plasmon resonance (SPR) absorption bands were taken with UV-Vis spectrophotometer. Read out full article here: http://www.eurekaselect.com/161194
While some randomized clinical trials have reduced the indications for cerebral revascularization in the secondary prevention of ischemic stroke, a distinct subset of patients with blood pressure augmentation dependent cerebrovascular insufficiency due to large vessel occlusions remains unaddressed. With the recent paradigm shifts in acute ischemic stroke care, the role of extracranial to intracranial (EC-IC) bypass must be re-addressed when endovascular intervention is not a feasible option. We submit a refined classification of cerebrovascular insufficiency with a category called Pressor-Dependent Cerebrovascular Insufficiency (PD-CVI) for whom EC-IC bypass may be indicated. Read out full article here: http://www.eurekaselect.com/163730