Podcast | Concise Review on the Applications of Magnetically Separable Brønsted Acidic Catalysts

Journal Name:Current Organic Chemistry 

Author(s): Jagatheeswaran Kothandapani, Subramaniapillai S. Ganesan*.




For article details, please visit: http://www.eurekaselect.com/170659

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EDITOR’S CHOICE – Polyfunctionalized Pyrrole Derivatives

Journal: Current Microwave Chemistry

Author(s): Stella Manta, Niki Tzioumaki, Nikolaos Kollatos, Pelagia Andrea, Marili Margaritouli, Aggeliki Panagiotopoulou, Ioannis Papanastasiou, Christos Mitsos, Andrew Tsotinis, Dominique Schols, Dimitri Komiotis*

Graphical Abstract:



Background: A large number of compounds with important biological properties contain the pyrrole heterocyclic system as main structural feature.

Methods: The synthesis of substituted pyrrole derivatives was carried out via a one-pot multicomponent reaction of sodium diethyl oxalacetate (3) with an equimolar amount of various aromatic aldehydes 1 and primary amines 2, in ethanol, using microwave irradiation. The newly synthesized compounds were evaluated for their potential cytostatic and antiviral activities in various cell culture lines.

Results: A range of novel pyrrole derivatives (4-13) were synthesized in a convenient one-step procedure. 3-Hydroxy-1-methyl-2-oxo-5-(3-chlorophenyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester (9b) showed a noteworthy activity against leukemia, while all new pyrrole adducts were potent against the Yellow Fever Virus in Vero cells.

Conclusion: A new protocol, employing a three-component reaction under microwave irradiation, enabled the rapid synthesis of 3-hydroxy-2-oxopyrroles has been developed, providing access to compounds with significant antiviral activities.

Read more here: http://www.eurekaselect.com/160013/article 

Highlighted Article – A New Multicomponent Reaction MCR4 For the Synthesis of Analogs of Staurosporine – Current Organic Chemistry

COC- Articles_21-28-Gerardo Byk.jpg

To access this article, please visit: http://www.eurekaselect.com/154987

Most Accessed Article – “Ru-Hydroxyapatite: An Efficient and Reusable Catalyst for the Multicomponent Synthesis of Pyranopyrazoles under Facile Green Conditions”

Journal: Current Organic Synthesis

Author(s): Surya Narayana Maddila, Suresh Maddila, Werner E. van Zyl, Sreekantha B. Jonnalgadda



An efficient, green and facile protocol for the synthesis of pyranopyrazole derivatives through the reaction of aromatic aldehydes, malononitrile, hydrazine hydrate and ethyl acetoacetate was developed using Ru loaded hydroxyapatite (Ru-CaHAp) as catalyst. The eco-friendly one-pot reactions in an ethanol-water mixture are fast (15 min) and occur at room temperature. The catalyst was fully characterized by various techniques. The chemical structures of the synthesized compounds were identified and confirmed by 1H, 15N and 13C NMR, FT-IR and HR-MS spectral data. The noteworthy advantages offered by this method are an environmentally-friendly simple procedure, mild conditions, short reaction times, recycling of catalyst and good to excellent (89 to 98%) yield of products.

To access the article, please visit: http://www.eurekaselect.com/137968 



Contributions by Japanese authors in Bentham Science journal ‘Current Organic Synthesis’

Synthesis of Asymmetric Diaryl Sulfides by SNAr Reaction of Substituted Nitrobenzene with Aryl Disulfides

Author(s): Naoki Enjo, Rong Lu and Tetsuo Miyakoshi.

Abstract: A series of sulfides was successfully synthesized from nitroarenes by SNAr reaction via elimination of a nitro or phenylsulfonyl group. The SNAr reaction mechanism is found to depend on the position and type of substituents, and the effect of two-electron withdrawing groups was also examined.

-See more http://benthamscience.com/journal/abstracts.php?journalID=cos&articleID=120222

Two Neglected Multicomponent Reactions: Asinger and Groebke Reaction for Constructing Thiazolines and Imidazolines

Author(s): Zai-Qun Liu.

Abstract: The multicomponent reaction (MCR) is an important research field in the organic synthetic methodology. In 1956, Professor Friedrich Asinger reported a method for synthesizing thiazoline scaffold, in which a ketone was treated by sulfur and ammonia in one-pot operation. In 1998, Professor Katrin Groebke, Hugues Bienayme, and Christopher Blackburn reported a method for preparing imidazo[1,2-a]pyridine, in which an annulation took place among α- aminopyridine, aldehyde, and isocyanide in one-pot operation, and then the reaction was entitled as Groebke reaction. Comparing with the bloom in the research of other MCRs such as Strecker (found in 1850), Hantzsch (1882), Biginelli (1891), Mannich (1912), Passerini (1921) and Ugi (1959) MCR, as newcomers in the family of MCR, Asinger and Groebke reactions are not reported as usually as other MCRs. The aim of the present review is to emphasize the importance of these two MCRs in the synthesis of thiazolines and imidazolines. 

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