OPEN ACCESS ARTICLE – Comparative Neurophysiologic Study of Pain in Patients with Parkinson’s Disease and Patients with Persistent Pain After Spinal Surgery – Neuroscience and Biomedical Engineering

Journal: Neuroscience and Biomedical Engineering

Author(s): Masanaka Takeda, Hisao Tachibana, Fumiaki Okada, Shuhei Kasama, Hiroo Yoshikawa

Graphical Abstract:

Abstract:

Background: Pain is a common and troublesome non-motor symptom in Parkinson’s disease (PD). Similarly, severe postoperative pain is common after major spinal surgery and may become chronic. The pathophysiologic mechanism underlying those conditions remains unclear. In this study, we recorded pain-related evoked potentials induced by intra-epidermal electrical stimulation in patients with PD and patients with persistent pain after spinal surgery and compared the results between the two groups.

Objective: The purpose of this study was to investigate the pathophysiology of pain in patients with persistent pain after spinal surgery and in patients with PD.

Methods: We recorded pain-related evoked potentials in 23 patients with PD (64.0 years), 6 patients with persistent pain after spinal surgery (69.5 years) and 12 healthy controls (59.6 years).

Results: Major negative (N1) and positive (P1) deflections were observed after each stimulation. The amplitudes between N1 and P1 (N1-P1), which are thought to originate from the anterior cingulate cortex and insula, were significantly lower in both patients with PD and persistent pain after spinal surgery than in the controls (both P<0.01). However, there was no significant difference in N1-P1 amplitude between the patients with PD and the patients with persistent pain after spinal surgery. No significant differences in N1 and P1 latencies were observed among the three groups.

Conclusion: These results suggest that abnormal central processing of pain is present in patients with PD and those with chronic persistent pain after spinal surgery and that these two conditions share similar pathophysiologic mechanisms, at least partially.

Read more here: http://www.eurekaselect.com/152597

Wishing A Very Happy Birthday Dr. Jinglong Wu!

Dr. Jinglong Wu

Dr. Jinglong Wu

EDITOR-IN-CHIEF: Neuroscience and Biomedical Engineering

Graduate School of Natural Science and Technology, Okayama University
Okayama
Japan

New Issue :: Neuroscience and Biomedical Engineering 4, Issue 4

NBE is the official journal of the Institute of Complex Medical Engineering (ICME). The journal promotes the best interdisciplinary research in neuroscience and biomedical engineering. NBE welcomes contributions in any domain of neural and biomedical engineering ranging in content from practical/clinical applications through experimental science, technological developments to quantitative and/or statistical methodology discussions. NBE publishes the following article types: original articles, research reviews, and book reviews.
The goal of this journal is to establish a new forum for this interdisciplinary field so that neuroscientists and biomedical engineers can publish their research works in one periodical. NBE is devoted to bridge the gap between Neuroscience and Biomedical Engineering, and to foster the mutual understanding in both fields.

nbe

Articles from the journal Neuroscience and Biomedical Engineering 4, Issue 4:

                       For details on the articles, please visit this link :: http://bit.ly/2op7vl3

 

New Issue :: Neuroscience and Biomedical Engineering 4, Issue 3

Neuroscience and Biomedical Engineering is the official journal of the Institute of Complex Medical Engineering (ICME). The journal promotes the best interdisciplinary research in neuroscience and biomedical engineering. NBE welcomes contributions in any domain of neural and biomedical engineering ranging in content from practical/clinical applications through experimental science, technological developments to quantitative and/or statistical methodology discussions. NBE publishes the following article types: original articles, research reviews, and book reviews.

The goal of this journal is to establish a new forum for this interdisciplinary field so that neuroscientists and biomedical engineers can publish their research works in one periodical. NBE is devoted to bridge the gap between Neuroscience and Biomedical Engineering, and to foster the mutual understanding in both fields.

nbe

Articles from the journal Neuroscience and Biomedical Engineering 4, Issue 3:

                   For details on the articles, please visit this link :: http://bit.ly/2lEE80j

Wishing A Very Happy Birthday To Dr. Kewei Chen!

FP-PPD-16-1700-26

Dr. Kewei Chen

Editor-in-Chief: Neuroscience and Biomedical Engineering 

Room 108, 901

E. Willetta Dr. Phoenix,

AZ 85006, USA

New Issue ::: Neuroscience and Biomedical Engineering, 4 Issue 2

NBE is the official journal of the Institute of Complex Medical Engineering (ICME). The journal promotes the best interdisciplinary research in neuroscience and biomedical engineering. NBE welcomes contributions in any domain of neural and biomedical engineering ranging in content from practical/clinical applications through experimental science, technological developments to quantitative and/or statistical methodology discussions. NBE publishes the following article types: original articles, research reviews, and book reviews.

Articles from the journal Neuroscience and Biomedical Engineering, 4 Issue 2

For details on the articles, please visit this link :: http://bit.ly/2bwY2Bu

Recently published issues in various journals of Bentham Science

Current Pharmaceutical Design, 22 Issue 19

http://bit.ly/1QcQdDR     

Adolescent Psychiatry , 5 Issue 4

http://bit.ly/1UeQt1A   

 Combinatorial Chemistry & High Throughput Screening, 19 Issue 5

http://bit.ly/1YyhZwq    

Neuroscience and Biomedical Engineering, 4 Issue 1

http://bit.ly/28MfBXh    

Current Alzheimer Research, 13 Issue 7

http://bit.ly/1tuODmz   

Recent Patents on Anti-Infective Drug Discovery , 11 Issue 1

http://bit.ly/1UBI6AQ    

Current Physical Chemistry, 6 Issue 2

http://bit.ly/1W4XZkm      

Current Pharmacogenomics and Personalized Medicine, 13 Issue 2

http://bit.ly/1QcQAhJ   

Current Drug Therapy, 11 Issue 1

http://bit.ly/1tBkZwv  

Current Medicinal Chemistry, 23 Issue 14

http://bit.ly/2634KJJ   

Current Proteomics , 13 Issue 2

http://bit.ly/1sL8xK2     

Current Angiogenesis, 4 Issue 1

http://bit.ly/1sL8xK2

recently published issue

 

Editor’s Choice Article : “Early Detection of Epileptic Seizures in Sparse Domains”

Journal: Neuroscience and Biomedical Engineering

Author(s): Davide Conigliaro, Paolo Manganotti and Gloria Menegaz

nbeAbstract: This work presents a method for early detection of epileptic seizures from EEG data, taking into account information about both the temporal and the spatial evolution of the seizures. The system was designed using over 8 hours of EEG, including 10 seizures in 5 patients. Seizure detection was accomplished in three main stages: multiresolution overcomplete decomposition by the à-trous algorithm, feature extraction by computing power spectral density and sample entropy values of subbands and detection by using z-test and support vector machines (SVM). Results highlight large differences between the sub-band sample entropy values during ictal and normal EEG epochs, respectively, reveling a substantial increase of such parameter during the seizure. This enables high detection accuracy and specificity especially in beta and gamma bands (16-125 Hz). The detection performance of the proposed method was evaluated based on the ground truth provided by the expert neurophysiologist, and the results show that our technique is capable to obtain a high accuracy (above the 95% on average), with a high temporal resolution. This enables reaching very low detection latency and early detection of the seizures onset. Furthermore, spatial information, within the limits of the acquisition, on the evolution of the seizure is maintained since all the channels are separately processed.

Read more here: http://benthamscience.com/journals/neuroscience-and-biomedical-engineering/volume/2/issue/1/page/14/