New Issue | Current Neuropharmacology ; Volume 18 Issue 2

 

CN

AIMS & SCOPE

Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience.

The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.

 

Articles from the journal: Current Neuropharmacology; Volume 18 Issue 2

For details on the articles, please visit this link: http://www.eurekaselect.com/node/603/current-neuropharmacology/issue/18/2718/2/9592

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Wishing you a very Happy Birthday | Prof. Kenneth Maise

 

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Prof. Kenneth Maise

Editor-in-Chief: Current Neurovascular Research

 

Neurology and Neurosciences UMDNJ
205 South Orange Avenue, F1220
Newark, NJ 07101
USA

Article by Disease – “Nanowired Drug Delivery Across the Blood-Brain Barrier in Central Nervous System Injury and Repair”

Article by Disease on “Neuroscience

Abstract:

The blood-brain barrier (BBB) is a physiological regulator of transport of essential items from blood to brain for the maintenance of homeostasis of the central nervous system (CNS) within narrow limits. The BBB is also responsible for export of harmful or metabolic products from brain to blood to keep the CNS fluid microenvironment healthy. However, noxious insults to the brain caused by trauma, ischemia or environmental/chemical toxins alter the BBB function to small as well as large molecules e.g., proteins. When proteins enter the CNS fluid microenvironment, development of brain edema occurs due to altered osmotic balance between blood and brain. On the other hand, almost all neurodegenerative diseases and traumatic insults to the CNS and subsequent BBB dysfunction lead to edema formation and cell injury. To treat these brain disorders suitable drug therapy reaching their brain targets is needed. However, due to edema formation or only a focal disruption of the BBB e.g., around brain tumors, many drugs are unable to reach their CNS targets in sufficient quantity. This results in poor therapeutic outcome. Thus, new technology such as nanodelivery is needed for drugs to reach their CNS targets and be effective. In this review, use of nanowires as a possible novel tool to enhance drug delivery into the CNS in various disease models is discussed based on our investigations. These data show that nanowired delivery of drugs may have superior neuroprotective ability to treat several CNS diseases effectively indicating their role in future therapeutic strategies.

Read more: http://www.eurekaselect.com/node/144937/article

Highlighted Article Flyer for the journal “CNS & Neurological Disorders – Drug Targets”

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http://benthamscience.com/journals/cns-and-neurological-disorders-drug-targets/

Highlighted Article Flyer for the journal “CNS & Neurological Disorders – Drug Targets”

CNS & ND-Articles_15-5- Hua Liu

http://benthamscience.com/journals/cns-and-neurological-disorders-drug-targets/

Highlighted Article Flyer for the journal “Current Neuropharmacology”

CN-Articles_14-4- A G Lewis

http://benthamscience.com/journals/current-neuropharmacology/

Highlighted Article Flyer for the journal “Current Aging Science”

CAS-Articles-9-3-Koji Nishio

http://benthamscience.com/journals/current-aging-science/

Highlighted Article Flyer for the journal “Current Neuropharmacology”

CN-Articles_14-4-Xiao-Ping Wang

http://benthamscience.com/journals/current-neuropharmacology/

Highlighted Article Flyer for the journal “Current Neuropharmacology”

CN-Articles_14-4- A -Yekta Ozer

http://benthamscience.com/journals/current-neuropharmacology/

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