Animated Abstract | A Possible Modulation Mechanism of Intramolecular and Intermolecular Interactions for NCAM Polysialylation and Cell Migration

 

Journal Name: Current Topics in Medicinal Chemistry

Author(s): Bo Lu, Xue-Hui Liu, Si-Ming Liao, Zhi-Long Lu, Dong Chen, Frederic A. Troy II, Ri-Bo Huang*, Guo-Ping Zhou*.

 

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Abstract:

Polysialic acid (polySia) is a novel glycan that posttranslationally modifies neural cell adhesion molecules (NCAMs) in mammalian cells. Up-regulation of polySia-NCAM expression or NCAM polysialylation is associated with tumor cell migration and progression in many metastatic cancers and neurocognition. It has been known that two highly homologous mammalian polysialyltransferases (polySTs), ST8Sia II (STX) and ST8Sia IV (PST), can catalyze polysialylation of NCAM, and two polybasic domains, polybasic region (PBR) and polysialyltransferase domain (PSTD) in polySTs play key roles in affecting polyST activity or NCAM polysialylation. However, the molecular mechanisms of NCAM polysialylation and cell migration are still not entirely clear. In this minireview, the recent research results about the intermolecular interactions between the PBR and NCAM, the PSTD and cytidine monophosphate-sialic acid (CMP-Sia), the PSTD and polySia, and as well as the intramolecular interaction between the PBR and the PSTD within the polyST, are summarized. Based on these cooperative interactions, we have built a novel model of NCAM polysialylation and cell migration mechanisms, which may be helpful to design and develop new polysialyltransferase inhibitors. To know more about our Animated Abstract, please visit: http://www.eurekaselect.com/175822/article

Open Access Articles | An Overview of Current Methods to Confirm Protein-Protein Interactions

Journal Name: Protein & Peptide Letters

Author(s): Kenji Miura*.

 

 

 

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Abstract:

Background: The research field of protein-protein interactions is interdisciplinary and specialized field that spans all aspects of biology, physics and chemistry. Therefore, in order to discuss the protein-protein interaction in detail and rigorously, it is desirable to integrate knowledge and methods of many related fields including boundary areas such as biochemistry, biophysics and physical chemistry in addition to biology, physics and chemistry.

Objective: The purpose of this review is to overview current methods to confirm protein-protein interactions. Furthermore, I discuss future prospects of methodology based on current status.

Results: It is often necessary to integrate, combine and validate multiple results from various methods to understand protein-protein interactions in detail.

Conclusion: It might be desirable for the addition of tags, labeling, and immobilization to solid phases to be unnecessary, and to obtain information on affinity, kinetics, and structure via the analytical method for protein-protein interactions. Therefore, I argue that novel methods based on principles that have already been sufficiently studied in physics or chemistry, but insufficiently applied to the life sciences, should be established to further develop the study of protein-protein interactions.

 

 

Read out more at:  http://www.eurekaselect.com/164836

PRESS RELEASE – Metabolomics, a promising tool for advancing in treatment personalization of oncological patients

This article by Dr. Leonor Puchades-Carrasco and Dr. Antonio Pineda- Lucena is published in Current Topics in Medicinal Chemistry, Volume 17 , Issue 24 , 2017

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Metabolomics, the analysis of the complete set of metabolites in a defined biological compartment, is a relatively novel approach. Metabolomics studies have been successfully applied to get a better understanding of many diseases, including a number of neoplastic processes. In this context, it is important to underline that cancer patients exhibit metabolic profiles that are different from those of healthy individuals and patients with benign diseases. Moreover, the site, the stage, and the location of the tumors have been shown to further alter the metabolic composition.

Currently, tumors are defined not only by their location but also by their molecular characteristics. The identification of specific mutations in tumors has started to play a critical role when determining therapeutic treatments. However, that information is not currently available for the majority of cancers, and the existing biomarkers are far from being optimal. Furthermore, there is considerable heterogeneity within the current definitions of pathological process, exemplified by the fact that patients who are given an identical diagnosis react differently to the same therapy and have different outcomes. In this context, metabolomics, in combination with other “omics” approaches, could contribute to get a deeper insight into the molecular mechanisms underlying pathological processes, thus facilitating the classification of patients and their therapeutic treatment.

Precision medicine promises to tailor therapies for each individual by delivering more effective drug treatments, while avoiding or reducing adverse drug reactions. Towards this end, considerable efforts have been made over the last few years in the field of pharmacogenomics, with a focus on genotyping and identifying specific genetic variations associated with drug response. However, clinical pharmacology would benefit from the introduction of new methodologies capable of providing information that could complement this genomic information. This is necessary because drug metabolism and utilization involves many different enzymes, multiple organs, several compartments and even the microbiome, being not always possible to screen for all possible genetic or tissue variants. Furthermore, because drug metabolism varies with ethnicity, age, gender, weight, height and diet – as well as other environmental and physiological variables – it can be particularly challenging to predict how an individual will respond to a drug based on their genotype alone.

In this context, the ability to directly and accurately assess the biological phenotype of patients will be a critical component in determining the correct drug treatment or in predicting the response following a therapeutic treatment. Metabolites are the final products of cellular regulatory processes and their levels can be regarded as the ultimate response of biological systems to genetic and environmental changes. Similarly, to the terms ‘transcriptome’ or ‘proteome’, the set of metabolites synthetized by a biological system constitutes its ‘metabolome’. Since the metabolome is closely tied to the genotype of an individual as well as its physiology and the surrounding environment, metabolomics offers a unique opportunity to look at genotype-phenotype and genotype-environment relationships. Metabolomics is closely linked to the overall physiopathological status of an individual. Thus, metabolomics may incorporate the biochemical events of thousands of small molecules in cells, tissues, organs, or biological fluids. Disease state or drug exposure could alter such metabolite composition in qualitative and quantitative terms generating complex metabolic signatures. The analysis of these signatures can potentially provide useful information for the diagnosis and prognosis of patients as well as for predicting pharmacological responses to specific interventions. Additionally, specific metabolic signatures occur after drug treatment, thus providing information from pathways targeted or affected by drug therapy.

This review provides specific examples of metabolomics applications in the field of clinical pharmacology and precision medicine with a focus on the therapeutic management of cancer and in the translation of these results to the clinics.

OPEN ACCESS ARTICLE – Metabolomics Applications in Precision Medicine: An Oncological Perspective – Current Topics in Medicinal Chemistry

Journal: Current Topics in Medicinal Chemistry

Author(s): Leonor Puchades-Carrasco, Antonio Pineda- Lucena

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Abstract:

Nowadays, cancer therapy remains limited by the conventional one-size-fits-all approach. In this context, treatment decisions are based on the clinical stage of disease but fail to ascertain the individual ´s underlying biology and its role in driving malignancy. The identification of better therapies for cancer treatment is thus limited by the lack of sufficient data regarding the characterization of specific biochemical signatures associated with each particular cancer patient or group of patients. Metabolomics approaches promise a better understanding of cancer, a disease characterized by significant alterations in bioenergetic metabolism, by identifying changes in the pattern of metabolite expression in addition to changes in the concentration of individual metabolites as well as alterations in biochemical pathways. These approaches hold the potential of identifying novel biomarkers with different clinical applications, including the development of more specific diagnostic methods based on the characterization of metabolic subtypes, the monitoring of currently used cancer therapeutics to evaluate the response and the prognostic outcome with a given therapy, and the evaluation of the mechanisms involved in disease relapse and drug resistance. This review discusses metabolomics applications in different oncological processes underlining the potential of this omics approach to further advance the implementation of precision medicine in the oncology area.

 

Read more here: http://www.eurekaselect.com/153940

 

 

Recent issues of Bentham Science Journals have been published

Current Rheumatology Reviews, 10 Issue 1

Aims & Scope

Current Rheumatology Reviews publishes frontier reviews, original research articles, drug clinical trial studies and guest edited thematic issues on all the latest advances on rheumatology and its related areas e.g. pharmacology, pathogenesis, epidemiology, clinical care and therapy. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field.

http://www.eurekaselect.com/124841/issue/1

Abstracted & Indexed in:

PubMed/ Medline, Chemical Abstracts, EMBASE, Scopus, EMNursing, PubsHub, Genamics JournalSeek, MediaFinder®-Standard Periodical Directory, and J-Gate.

For more details please visit: http://benthamscience.com/journal/index.php?journalID=crr

 

Current Pharmaceutical Biotechnology, 15 Issue 7

Aims & Scope

Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal contains a series of timely in-depth reviews, research articles and letters written by leaders in the field covering a range of current topics in both pre-clinical and clinical areas of Pharmaceutical Biotechnology. Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.

http://www.eurekaselect.com/124812/issue/7

Abstracted & Indexed in:

Chemical Abstracts, MEDLINE/Index Medicus, BIOSIS, EMBASE/Excerpta Medica, BIOBASE, Science Citation Index Expanded, Biochemistry & Biophysics Citation Index, Journal Citation Reports/Science Edition, Current Contents®/Life Sciences, Biotechnology Citation IndexTM, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, Index to Scientific Reviews®, Scopus, EMBiology, Genamics JournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, and J-Gate.

For more details please visit: http://benthamscience.com/journal/index.php?journalID=cpb

 

Recent Advances in Communications and Networking Technology , 3 Issue 1

Aims & Scope

Recent Advances in Communications and Networking Technology publishes review and research articles, and guest edited thematic issues by experts on new advances in communications and networking technology, including reviews on recent patents. The journal also covers recent research in fast emerging areas of the field of communications (including communications software, services, and multimedia applications, cognitive networks, Internet, wireless communications, optical, ad-hoc and sensor networks, etc.) and related issues, as well as networking technology. The journal is essential reading for all researchers involved in telecommunication and networking science and technology.

http://www.eurekaselect.com/124868/issue/1

Abstracted & Indexed in:

J-Gate, and PubsHub.

For more details please visit: http://benthamscience.com/journal/index.php?journalID=racnt

 

Recent Patents on Computer Science, 7 Issue 1

Aims & Scope

Recent Patents on Computer Science publishes review and research articles, and guest edited thematic issues on recent patents in all areas of computer science. A selection of important and recent patents on computer science is also included in the journal. The journal is essential reading for all researchers involved in computer science. The journal also covers recent research (where patents have been registered) in fast emerging computation methods, bioinformatics, medical informatics, computer graphics, artificial intelligence, cybernetics, hardware architectures, software, theory and methods involved and related to computer science.

http://www.eurekaselect.com/124866/issue/1

Abstracted & Indexed in:

Engineering Village/Compendex, Scopus, Genamics JournalSeek, MediaFinder®-Standard Periodical Directory, J-Gate, and PubsHub.

For more details please visit: http://benthamscience.com/journal/index.php?journalID=rpcseng

 

Current Proteomics, 11 Issue 2

Aims & Scope

The principal aim of Current Proteomics is to publish well-timed review articles in this fast-expanding area on topics relevant and significant to the development of proteomics. Current Proteomics is an essential journal for everyone involved in proteomics and related fields in both academia and industry.

http://www.eurekaselect.com/124694/issue/2

Abstracted & Indexed in:

Chemical Abstracts, BIOSIS Previews, BIOSIS Reviews Report and Meetings, Scopus, BIOBASE, EMBiology, Science Citation Index Expanded (SciSearch), Index to Scientific Reviews, Biotechnology Citation Index, Journal Citation Reports/Science Edition, Genamics JournalSeek, Mediafinder- Standard Periodical Directory, PubsHub, and J-Gate.

For more details please visit: http://benthamscience.com/journal/index.php?journalID=cp

 

Combinatorial Chemistry & High Throughput Screening, 17 Issue 8

Aims & Scope

Combinatorial Chemistry & High Throughput Screening(CCHTS) publishes full length original research articles and reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research.

http://www.eurekaselect.com/124818/issue/8

Abstracted & Indexed in:

Chemical Abstracts, Current Contents®/Life Sciences, EMBASE/Excerpta Medica, MEDLINE/Index Medicus, Science Citation Index ExpandedTM, BIOBASE, CAB Abstracts, Journal Citation Reports/Science Edition, Chemistry Citation Index®, Reaction Citation Index®, Biological Abstracts, BIOSIS, BIOSIS Previews, Scopus, EMBiology, Genamics JournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, and J-Gate.

For more details please visit: http://benthamscience.com/journal/index.php?journalID=cchts

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