Podcast: Long-term Lifestyle-modification Programs For Overweight And Obesity Management In The Arab States

Author(s): Dima Kreidieh, Leila Itani, Germine El Kassas, Dana El Masri, Simona Calugi, Riccardo Dalle Grave, Marwan El Ghoch

For article details, visit: http://www.eurekaselect.com/153397/article

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Article by Disease – “FoxO1 Inhibitors: The Future Medicine for Metabolic Disorders?”

Article by Disease on “Metabolism”

Abstract:

FoxO1, one of the most widely expressed sub-families of the winged helix forkhead factors, is biologically ‘omni-functional’ owing to its far-flung roles in metabolism, cell cycle, tissue differentiation and development and oxidative stress response. The knowledge of involvement of FoxO1 in metabolic disorders has long been there, but the potential target remained underutilized due to unavailability of specific and potent inhibitors. The review provides an insight into the role of FoxO1 in orchestrating metabolic diseases’ pathogenesis (including diabetes, its secondary complications and obesity) and compiles the literature on FoxO1 inhibitors. The emergence of various natural molecules and synthesized small molecules like AS1842856 as FoxO1 inhibitors urges us to think further and decide the future course of drug development for the management of metabolic disorders.

Read more: http://benthamscience.com/journals/current-diabetes-reviews/volume/12/issue/3/page/223/

Article by Disease-“Development and Validation of a UPLC–MS/MS Method for the Simultaneous Determination of Telmisartan and Metformine HCl in Human Plasma”

Article by Disease on “Obesity”

Abstract: Obesity, impaired glucose tolerance, and hypertension are often related and represent a major health burden in modern societies. Telmisartan (TEL) and Metformin HCl (MET) are widely used for the management of these commonly associated diseases. Few attempts have been made for the determination of TEL and MET in human plasma by liquid chromatography tandem mass spectrometry. This study describes the first chromatographic method for the simultaneous quantitation of TEL and MET in human plasma by ultra-performance liquid chromatography coupled to quadruple tandem mass spectrometry (UPLC–MS/MS). Chromatography was performed on aC18 column with isocratic elution using a mobile phase consisting of acetonitrile, water and formic acid (88.2 11.7: 0.1), at a flow rate of 250 μL/min for a total run time of 2 min. Losartan (LOS) was used as the internal standard. Mass spectrometric analysis was carried out by a TSQ Quantum Access MAX triple quadruple system coupled with electro spray ionization (ESI) source in the positive ion mode. The assay was validated over a concentration range of 10–100 ng/ml for both drugs. The precision and accuracy for both intra- and inter-day determination of all analytes were acceptable (<15%). Stability of the compounds was established for short term bench and auto sampler storage as well as freeze/thaw cycles. Moreover, the method was successfully applied to a pharmacokinetic study in six healthy volunteers who had been given a single oral dose of metformin HCl and telmisartan, 500 mg and 40 mg, respectively.

Read more: http://benthamscience.com/journals/current-analytical-chemistry/volume/11/issue/2/page/130/

Highlighted Article Flyer for the journal “Current Drug Targets”

CDT-Articles-17-11-  Darakhshan Jabeen Haleem

http://benthamscience.com/journals/current-drug-targets/

Article by disease – Obesity

“Modification of Lifestyle Factors are Needed to Improve the Metabolic Health of Patients with Cardiovascular Disease Risk”

Author(s): Linda Landini

Abstract:

Cardiovascular risk factors, irregardless of their assessment modalities, are based on cardiovascular health. Lifestyle influences metabolic profiles and these changes affect cardiovascular risk factors.

Cardiovascular risk factors can be classified into three basic categories: 1. Predisposing risk factors (e.g., age, gender, medical history, and genetic factors); 2. Clinical and metabolic factors (e.g., hypertension, changes in lipid metabolism, diabetes mellitus, obesity, metabolic syndrome, homocysteine, serum uric acid concetntrations, and L-arginine dimethylated derivatives); 3. Modifying behavioral factors (e.g., cigarette smoking, high caloric diet, alcohol intake, sedentary life). Some of these factors are metabolic components of body metabolism because they act by metabolic reactions while others characterized by structural alterations of the cardiovascular system, at least initially, exert their harmful effects by metabolic substrates.

Metabolic responses such as biochemical substances, drugs or others, that act initially as cardiovascular risk factors, identify that an early treatment of the altered parameters observed should be a useful approach to reduce the rate of heart attacks with a significant improvement in the outcome of cardiovascular disease.

– See more at: http://www.eurekaselect.com/121625/article#sthash.TmyPDExJ.dpuf

EurekAlert! – Obesity and male infertility: A global health problem

Infertility is a silent problem that obese men have to face. This is a health issue that deserves attention from policymakers and the media.

The increasing number of overweight/obese individuals has established obesity as one of the most relevant health problems for years to come. Subfertility or infertility are silent problems that overweight/obese men have to face. This is particularly relevant since there is an enormous increase of children, adolescents and young adult men who are overweight or obese. This is a health issue that should be carefully addressed and deserves attention from policymakers and the media.

Dietary habits have an impact on male reproductive potential. A team led by Professor Pedro F. Oliveira at University of Porto, Portugal recently published a paper in the “Current Pharmaceutical Design” Journal discussing obesity and its impact on the reproductive potential of males. “Obesity is a metabolic disease that promotes a strong hormonal dysfunction. Gut hormones are known to be strongly affected by the energy unbalance induced by overconsumption of food. However, the impact of those hormones on male reproductive system remains unknown”, explained Marco G. Alves, first author of the paper. He further added that “Gut and adipose hormones are currently on spotlight for a growing number of researchers and the pandemic numbers of obesity highlights their relevance. A complete elucidation of male fertility involving those hormones will have important clinical implications and also unveil mechanisms and pathways for a therapeutic approach in the treatment of male subfertility/infertility associated with obesity.”

Read more here: http://www.eurekalert.org/pub_releases/2016-04/bsp-oam041416.php

Prevalence of Obesity in Children and Adolescents in Brazil: A Meta-analysis of Cross-sectional Studies

Obesity in Children: An Overly Increasing Point of Worry, Especially In the American Continents

childhood-obesity

The world has been deeply concerned about the growing issue of children being overweight. North and South America in particular have been voicing concerns that the new generation is readily crossing the line of average normal weight. It is understood that overweight children are not so much at risk of developing other feared problems but as they grow older this very plumpness continues to grow with them. Obese adolescents and adults, however, are not very safe, for they are prone to dealing with chronic diseases like diabetes and cardiovascular disorders. Furthermore, they can also be a victim of psychological problems like stress, depression and low confidence.

When we consider how different genders exhibit obesity occurrence, we find that the chance is nearly equal. It is evident from the research ‘Prevalence of Obesity in Children and Adolescents in Brazil: A Meta-analysis of Cross-sectional Studies which was published in the scientific journal, Current Pediatric Reviews. This study was conducted by a team of researchers from the Department of Social Medicine, Ribeirao Preto Medical School, University of Sao Paulo, to study how and how much obesity prevails in the youngsters in Brazil.

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As is commonly known, there are several reasons that cause weight gain among kids. There can be genetic inheritance or a problematic lifestyle with lack of physical activities, unhealthy diet, dullness and stress that can be blamed. Moreover, there can be some disease resulting in obesity.

The reason may be any, but it is high time we find measures to combat obesity.

Articles by Diseases – TYPE 1 OBESITY

 

Food Addiction Spectrum: A Theoretical Model from Normality to Eating and Overeating Disorders 

Author(s): Armando Piccinni, Donatella Marazziti, Federica Vanelli, Caterina Franceschini, Stefano Baroni, Davide Costanzo, Ivan Mirko Cremone, Antonello Veltri and Liliana Dell’Osso 

Abstract: The authors comment on the recently proposed food addiction spectrum that represents a theoretical model to understand the continuum between several conditions ranging from normality to pathological states, including eating disorders and obesity, as well as why some individuals show a peculiar attachment to food that can become an addiction. Further, they review the possible neurobiological underpinnings of these conditions that include dopaminergic neurotransmission and circuits that have long been implicated in drug addiction. The aim of this article is also that at stimulating a debate regarding the possible model of a food (or eating) addiction spectrum that may be helpful towards the search of novel therapeutic approaches to different pathological states related to disturbed feeding or overeating.

– See more at: http://www.eurekaselect.com/node/128902/article

 

See more articles categorized by diseases in the tab ‘Articles by Disease’ on our website www.benthamscience.com

 

Open Access Plus ::: Recent Patents on Anti-Cancer Drug Discovery

Circulatory Estrogen Level Protects Against Breast Cancer in Obese Women
Zsuzsanna Suba

Abstract: The use of TRAIL/APO2L and monoclonal antibodies targeting TRAIL receptors for cancer therapy holds great promise, due to their ability to restore cancer cell sensitivity to apoptosis in association with conventional chemotherapeutic drugs in a large variety of tumors. TRAIL-induced cell death is tightly regulated right from the membrane and at the DISC (Death-Inducing Signaling Complex) level. The following patent and literature review aims to present and highlight recent findings of the deadly discussion that determines tumor cell fate upon TRAIL engagement.

View Abstract Download Free

 

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Regulating TRAIL Receptor-Induced Cell Death at the Membrane: A Deadly Discussion
Sarah Shirley, Alexandre Morizot and Olivier Micheau

Abstract: Literary data suggest apparently ambiguous interaction between menopausal status and obesity-associated breast cancer risk based on the principle of the carcinogenic capacity of estrogen. Before menopause, breast cancer incidence is relatively low and adiposity is erroneously regarded as a protective factor against this tumor conferred by the obesity associated defective estrogen-synthesis. By contrast, in postmenopausal cases, obesity presents a strong risk factor for breast cancer being mistakenly attributed to the presumed excessive estrogen-production of their adipose-tissue mass. Obesity is associated with dysmetabolism and endangers the healthy equilibrium of sexual hormone-production and regular menstrual cycles in women, which are the prerequisites not only for reproductive capacity but also for somatic health…

View Abstract Download Free

‘Circulatory Estrogen Level Protects Against Breast Cancer in Obese Women’ by Zsuzsanna Suba

Abstract

Literary data suggest apparently ambiguous interaction between menopausal status and obesity-associated breast cancer risk based on the principle of the carcinogenic capacity of estrogen. Before menopause, breast cancer incidence is relatively low and adiposity is erroneously regarded as a protective factor against this tumor conferred by the obesity associated defective estrogen-synthesis. By contrast, in postmenopausal cases, obesity presents a strong risk factor for breast cancer being mistakenly attributed to the presumed excessive estrogen-production of their adipose-tissue mass. Obesity is associated with dysmetabolism and endangers the healthy equilibrium of sexual hormone-production and regular menstrual cycles in women, which are the prerequisites not only for reproductive capacity but also for somatic health. At the same time, literary data support that anovulatory infertility is a very strong risk for breast cancer in young women either with or without obesity. In the majority of premenopausal women, obesity associated insulin resistance is moderate and may be counteracted by their preserved circulatory estrogen level. Consequently, it is not obesity but rather the still sufficient estrogen-level, which may be protective against breast cancer in young adult females. In obese older women, never using hormone replacement therapy (HRT) the breast cancer risk is high, which is associated with their continuous estrogen loss and increasing insulin-resistance. By contrast, obese postmenopausal women using HRT, have a decreased risk for breast cancer as the protective effect of estrogen-substitution may counteract to their obesity associated systemic alterations. The revealed inverse correlation between circulatory estrogen-level and breast cancer risk in obese women should advance our understanding of breast cancer etiology and promotes primary prevention measures. New patents recommend various methods for the prevention and treatment of obesity-related systemic disorders and the associated breast cancer.

Read more here: http://bit.ly/1vIHUjJ

The article is taken from the journal ‘Recent Patents on Anti-Cancer Drug Discovery