Podcast: Research and Patents Status of Selected Phytochemicals Against Cancer: How Close and How Far?

Author(s):Homa Fatma and Hifzur R Siddique*

Background: Cancer is a global health issue and economic burden with a continuous increase in incidence and mortality. Over the years, the underlying molecular mechanism of cancers was thoroughly researched, leading to multiple drugs development. Unfortunately, most drugs have some serious drawbacks, such as therapy resistance and toxicity. Epidemiological studies have shown that a diet rich in fruits and vegetables has cancer-prevention properties, which shifted the attention to the potential role of phytochemicals in anti-carcinogenic activity.

Objective: To review the present status of phytochemicals research and patents in cancer prevention and chemosensitization.

Methods: We explored the relevant published articles and patents to review the phytochemicals showing cancer preventive role in preclinical settings from 1997 onwards.

Results: We summarise the role of phytochemicals on anti-carcinogenic, anti-inflammatory, antiproliferative, anti-metastatic, and pro-apoptotic activities in both in vitro and in vivo. Thus, phytochemicals might be an excellent chemosensitizing agent against chemoresistant cells and possibly one of the safest and most effective options for cancer therapy. However, one of the limitations of phytochemicals is their poor bioavailability and rapid excretion. Several analogs have been introduced to increase bioavailability, better biological efficacy, absorption, and retention. In fact, various phytochemicals and their analogs have been patented for their anti-cancerous properties.

Conclusion: This mini-review discusses various phytochemicals and their anti-cancerous and chemosensitizing roles. Due to their clinical relevance, recent trends in phytochemical extraction and exploration have shown that more and more phytochemicals are being patented.

Read the full article here: https://bit.ly/3wC5jeT

Open Access Article – Systematic Patent Review of Nanoparticles in Drug Delivery and Cancer Therapy in the Last Decade

Author(s):Nur Umairah Ali HazisNagender AnejaRajan Rajabalaya and Sheba Rani David*

Volume 15, Issue 1, 2021

Published on: 24 September, 2021

Page: [59 – 74]

Pages: 16

DOI: 10.2174/1872211314666210521105534


Background: The application of nanotechnology has been considered a powerful platform in improving the current situation in drug delivery and cancer therapy, especially in targeting the desired site of action.

Objective: The main objective of the patent review is to survey and review patents from the past ten years that are related to the two particular areas of nanomedicines.

Methods: The patents related to the nanoparticle-based inventions utilized in drug delivery and cancer treatment from 2010 onwards were browsed in databases like USPTO, WIPO, Google Patents, and Free Patents Online. After conducting numerous screening processes, a total of 40 patents were included in the patent analysis. See the PRISMA checklist 2020 checklist.

Results: Amongst the selected patents, an overview of various types of nanoparticles is presented in this paper, including polymeric, metallic, silica, lipid-based nanoparticles, quantum dots, carbon nanotubes, and albumin-based nanomedicines.

Conclusion: Nanomedicines’ advantages include improvements in terms of drug delivery, bioavailability, solubility, penetration, and stability of drugs. It is concluded that the utilization of nanoparticles in medicines is essential in the pursuit of better clinical practice. Read now: https://bit.ly/3zDFTjd

Aims & Scope – Recent Patents on Mechanical Engineering

ISSN (Print): 2212-7976
ISSN (Online): 1874-477X

Volume 15, Issue 5, 2022

Aims & Scope

Recent Patents on Mechanical Engineering publishes review and research articles that reflect or deal with studies in relation to a patent, application of reported patents in a study, discussion of comparison of results regarding application of a given patent, etc., and also guest edited thematic issues on recent patents in the field of mechanical engineering. A selection of important and recent patents on mechanical engineering is also included in the journal. The journal is essential reading for all researchers involved in mechanical engineering. The journal also covers recent research (where patents have been registered) in fast emerging analytical methods, designs, manufacturing and analysis of automobiles, aircrafts, aerodynamics, manufacturing plants, industrial instruments, industrial fluid power and control, machines, mechatronics, biomechanics, robotics, robot rehabilitation, lubrication and wear, acoustics and noise, heating and cooling systems, solar energy, turbines, vibration & control and processes involved and related to mechanical engineering. Read now: https://bit.ly/3usm8rO

Aims & Scope – Recent Patents on Anti-Infective Drug Discovery

Continued as: Recent Advances in Anti-Infective Drug Discovery

ISSN: 2212-4071 (Online)
ISSN: 1574-891X (Print)

Recent Patents on Anti-Infective Drug Discovery publishes review and research articles, drug clinical trial studies and guest edited thematic issues on recent patents in the field of anti-infective drug discovery e.g. on novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery. The journal also covers recent research (where patents have been registered) in fast emerging therapeutic areas/targets & therapeutic agents related to anti-infective drug discovery. Read Now: https://bit.ly/39US696

EDITOR’S CHOICE – Novel Patents Targeting Interleukin-17A; Implications in Cancer and Inflammation

Journal: Recent Patents on Anti-Cancer Drug Discovery

Author(s): Juan F. Santibanez*, Suncica Bjelica


Background: IL-17A is a founding member of the IL-17 family that has been implicated in the pathogenesis of inflammatory-associated diseases such as cancer and autoimmune disease. In cancer, IL-17A participates in many key events for tumor development, in part by affecting innate and adaptive immune system and also by direct modulation of many pro-tumor events. Moreover, IL-17A dysregulation at the site of inflammation is associated with rheumatoid arthritis, multiple sclerosis, psoriasis, among others. IL-17A has emerged as a topic of interest and is under profound investigation for its involvement in several types of inflammatory-associated diseases.

Objective: This review aims to present an overview of the state of the art of IL-17A role in cancer and inflammation, as well as to describe recent patents targeting IL-17A with relevant clinical and biological properties for the prevention and treatment of cancer and inflammatory diseases.

Methods: Relevant information was obtained by searching in PubMed using IL-17A or IL-17, cancer and inflammation as keywords, while relevant patents were obtained mainly from Google Patents.

Results: Literature data indicated IL-17A as important biomolecule in the physiopathology of cancer and inflammatory diseases. Whereas, novel patents (2010 to 2017) targeting IL-17A are focused mainly on describing strategies to modulate IL-17A per se, co-modulation by bispecific antibodies to blocking IL-17A and important cytokines for IL-17A functions, upstream mechanisms and compounds to regulate IL-17A expression.

Conclusion: The promising effects of patented agents against IL-17A may open new opportunities to therapeutic intervention targeting at different levels of involvement in the pathogenesis of cancer and inflammatory diseases.

Read more here: http://www.eurekaselect.com/159948/article


Press Release for EurekAlert! Probiotics: Novel biosynthetic tool to develop metallic nanoparticles

This research article by Dr. Nida Akhtar et al has been published in Recent Patents on Drug Delivery & Formulation, Volume 11, Issue 1, 2017


Probiotics, being live microbes, exert numerous beneficial health effects on the host cells. Such probiotics are commercially available as dietary supplements, foods, pharmaceutical formulations. Yakult, Activia yogurt, DanActive fermented milk provide health benefits like boosting up the immune system, treating digestive problems, mental illness, neurological disorders, cancer, etc. However, the use of probiotic bacteria to develop metallic nanoparticles (MNPs) constitutes novel research nowadays. Research inputs and patent reports according to an article published in the journal Recent Patents on Drug Delivery and Formulation highlight their potential in the field of cosmetics, pharmaceuticals, medicine and biotechnology as well.

Prof. Kamla Pathak, the corresponding author said: “Our review findings reinstate the potential of probiotic bacteria to produce MNPs. Patents (US, EP and WIPO patents) during 2009-2016 reaffirm the research and inspire the scientific community worldwide for future exploration. This is the first review article in this aspect that systematically tracks the intellectual aspects of applications and synthesis of MNPs by probiotic bacteria. Prof. Pathak said, “Our study details the interventions on which research on MNPs is on. Gold, silver, magnetic, selenium, iron oxide, magnetic-optical iron oxide-gold core-shell, magnesium oxide, copper oxide, aluminum oxide, titanium dioxide, zinc oxide nanoparticles have applications ranging from their usage in analytical methodologies to treat and diagnose diseases. Specifically, gold NPs are suggested for drug delivery and treating lymphocytic leukemia; silver and copper NPs for antimicrobial activity and zinc oxide NPs as anti-corrosive, antifungal and as an additive in food products such as breakfast cereals. These NPs need to be explored more as no patent till date was found on them based on their biosynthesis, according to the author’s report.

For more information about the article, please visit: http://www.eurekaselect.com/node/150848/article/probiotics-as-a-tool-to-biosynthesize-metallic-nanoparticles-research-reports-and-patents-survey

Testimonial by Dr. Orfeas Liangos!


Contributed Article: Update on AKI Biomarker Patents

Wishing A Very Happy Birthday To Dr. Togay Ozbakkaloglu


As the Editor-in-Chief of Recent Patents on Engineering we appreciate your contributions to Bentham Science. For latest articles in the journal, please visit: http://benthamscience.com/journals/recent-patents-on-engineering/


Thematic Issue Proposal Approved For May 2015 on “METABOLIC TARGETING OF CANCERS”

A thematic issue proposal entitled “Metabolic targeting of cancers” has been approved for proposal Recent Patents on Anti-Cancer Drug Discovery. The issue will be published in 2015 issue.

For details on this journal, click: http://benthamscience.com/journal/index.php?journalID=rpacdd


Volume 3, 2014 of the Patent e-Book Series “Topics in Anti-Cancer-Research” has been lined up and will be available online soon.

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