Editors Choice Article | Hysterosalpingographic Findings of Infertile Patients Presenting to Our Reproductive Endocrinology Department: Analysis of 1,996 Cases

 

Journal Name: Current Medical Imaging

Author(s): Zeynep Ozturk Inal*, Hasan Ali Inal, Aysegul Altunkeser, Ender Alkan, Fatma Zeynep Arslan

 

Graphical Abstract:

Abstract:

Background: To evaluate the hysterosalpingography (HSG) findings of women with infertility in a tertiary center located in central Turkey.

Methods: A total of 1,996 patients undergoing the HSG procedure for the investigation of infertility from April 2012 to 2017 were retrospectively evaluated using the archives of the reproductive endocrinology and radiology departments. Demographic and clinical characteristics of patients with normal HSG findings (n = 1,549) and patients with abnormal HSG findings (n = 447) were compared, and the distribution of pathologies on the HSG examinations was evaluated as well.

Results: There were statistically significant differences between patients with normal and abnormal HSG findings in terms of age (25.68 ± 4.54 vs. 35.87 ± 2.65, p < 0.001), type (for secondary) and duration of infertility [43.1% vs. 50.6% (p = 0.006); 7 (1-22) vs. 2 (1-12) (p < 0.001), respectively], and baseline follicle stimulating hormone and estradiol levels [7.22 ± 1.38 vs. 7.55 ± 1.42 (p < 0.001); 45.54 ± 9.92 vs. 44.40 ± 9.99 (p < 0.001), respectively]. Among a total of 1,996 HSG examinations, 447 (22.39%) showed abnormalities, of which 237 (11.87%) were associated with tubal pathologies, 163 (8.17%) with uterine pathologies, and 47 (2.35%) with a combination of both. While the most common tubal pathology was one-sided distal tubal occlusion (2.91%), the most common uterine pathology was filling defects (4.16%).

Conclusion: HSG is the most commonly used, well-tolerated, low-cost, and safe radiological procedure to use for the investigation of the causes of female infertility. To read out more, please visit: http://www.eurekaselect.com/165406/article

Press Release | Vitamin D intake and obesity in occupational asthma patients and need for supplementation

Occupational asthma is common occurrence in a significant number of adults suffering from the disease. Even after the cessation of exposure, the asthma remains dominant. Previously, Vitamin D intake was rarely evaluated in cases of occupational asthma regardless of it being an important part of nutrition. The main objective of this study is to assess the Vitamin D intake in occupational asthma patients and its relation with body mass index, co-morbidities related to Vitamin D deficit, lung function and quality of life.

The researchers found a reduced Vitamin D intake in both irritant and allergic asthma both in obese and non-obese patients. Even though the average intake levels were comparably higher in non-obese patients than obese patients, it did not reach to a significant level. Lower intake was also found in mild asthma group compared to severe asthma group, marginally reaching significance level at the median test. Regression analysis revealed a different pattern in the asthma groups. The Impact score in irritant asthma indicated a stronger relationship with BMI while the symptom score in allergic asthma group was closely associated with the Vitamin D intake. Read full press release to find out more at: https://www.eurekalert.org/pub_releases/2018-12/bsp-vdi122718.php

 

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CREDIT: DR. MARINA RUXANDRA OTELEA, DR. AGRIPINA RASCU, BENTHAM SCIENCE PUBLISHERS

 

The article by Dr. Marina Ruxandra Otelea and Dr. Agripina Rascu is published in Endocrine, Metabolic & Immune Disorders – Drug Targets, Volume 18, Issue 6, 2018. To obtain the article, please visit: http://www.eurekaselect.com/163292

Most Accessed Articles – The Clinical and Immunological Features of Patients with Primary Antibody Deficiencies

Author(s): Gholamreza Azizi, Yasser Bagheri, Marzieh Tavakol, Forough Askarimoghaddam, Kumars Porrostami, Hosein Rafiemanesh, Reza Yazdani, Fatemeh Kiaee, Sima Habibi, Kosar Abouhamzeh, Hamed Mohammadi, Mostafa Qorbani, Hassan Abolhassani, Asghar Aghamohammadi*.

Graphical Abstract:

 

Abstract:

Background: Primary antibody deficiency (PAD) comprises a range of diseases from early to late terminal B cells defects and is associated with the various clinical complications.

Methods: A total of 461 patients (311 males and 150 females) with PADs enrolled in the retrospective cohort study and for all patients’ demographic information, clinical records and laboratory data were collected to investigate clinical complications.

Results: The most prevalent first presentations of immunodeficiency were respiratory tract infections in 63.5% and chronic diarrhea in 17.2%. Common variable immune deficiency (CVID) patients had a higher diagnostic delay than class switching defect (CSD), and agammaglobulinemia. Among the noninfectious complications, autoimmunity (26.2%), and splenomegaly (23.4%) were the most common. Lymphadenopathy was higher in CSD patients than other PADs, while splenomegaly, hepatomegaly, autoimmunity and bronchiectasis were more common in CVID patients than others. Atopic manifestations were mostly recorded in patients with selective IgA deficiency. Malignancy was only reported in 5.8% of patients with CVID. There was a higher prevalence of autoimmune manifestations in CVID comparing to other PADs.

Conclusion: PADs are relatively rare diseases and these patients have a variety of first clinical manifestations, such as diverse infections, autoimmunity, lymphoproliferation, allergy, enteropathy and malignancy. Practitioner’s awareness about the heterogeneous presentations of PAD disorders is poor, therefore patients often are lately diagnosed, and they are complicated with several clinical complications before the certain diagnosis.

 

For more details, please visit: http://www.eurekaselect.com/161253

Recent Issues of Bentham Science Journals have been Published

Inflammation & Allergy-Drug Targets, 13 Issue 4

Aims & scope

Inflammation & #Allergy – Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in inflammation and allergy e.g. disease specific proteins, receptors, enzymes, genes. The journal publishes expert in-depth reviews, original research articles, drug clinical trial studies and guest edited thematic issues covering a range of current topics on drug targets involved in inflammation and allergy. As the discovery, identification, characterization and validation of novel human drug targets for anti-inflammation and allergy drug discovery continue to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.

http://www.eurekaselect.com/124592/issue/4

Abstracted & Indexed in

Chemical Abstracts, BIOSIS, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, MEDLINE/Index Medicus, EMBASE/ExcerptaMedica, Scopus, PubsHub, GenamicsJournalSeek, MediaFinder®-Standard Periodical Directory, and J-Gate..

For details about the latest issues, visit:http://benthamscience.com/journal/index.php?journalID=iadt

 

Current Topics in Medicinal Chemistry, 14 Issue 14

Aims & scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

http://www.eurekaselect.com/124602/issue/14

Abstracted & Indexed in

BIOSIS, Chemical Abstracts, MEDLINE/Index Medicus, PUBMED, ISI, Science Citation Index ExpandedTM, Biochemistry & Biophysics Citation IndexTM, index to Scientific Reviews®, Current Contents®, EMBASE/ExcerptaMedica, Journal Citation Reports/Science Edition, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, Scopus, GenamicsJournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, and J-Gate.

For details about the latest issues, visit:http://benthamscience.com/journal/index.php?journalID=ctmc

 

Mini-Reviews in Organic Chemistry, 11 Issue 3

Aims & scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

http://www.eurekaselect.com/124555/issue/3

Abstracted & Indexed in

BIOSIS, Chemical Abstracts, MEDLINE/Index Medicus, PUBMED, ISI, Science Citation Index ExpandedTM, Biochemistry & Biophysics Citation IndexTM, index to Scientific Reviews®, Current Contents®, EMBASE/ExcerptaMedica, Journal Citation Reports/Science Edition, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, Scopus, GenamicsJournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, and J-Gate

For details about the latest issues, visit:http://benthamscience.com/journal/index.php?journalID=ctmc

 

Current Inorganic Chemistry, 4 Issue 2

Aims & scope

Current Inorganic #Chemistry, a peer-reviewed journal, publishing original research, review articles and guest edited thematic issues in all areas of inorganic chemistry. The journal’s scope includes the synthesis, crystal structure, physical methods, thermodynamics, reactivity, spectroscopy, electronic and bonding properties of significant new and known (bio) inorganic and organometallic compounds.

Current Inorganic Chemistry is an important and reliable source of information on current developments, research and theory in the field. The emphasis is on publishing high quality articles.

http://www.eurekaselect.com/124573/issue/2

Abstracted & Indexed in

Chemical Abstracts, MediaFinder®-Standard Periodical Directory, and J-Gate.

For details about the latest issues, visit: http://benthamscience.com/journal/index.php?journalID=cic

 

Current Drug Targets, 15 Issue 10

Aims & scope

Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes.

Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication mini- & full-length review articles and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

http://www.eurekaselect.com/124609/issue/10

Abstracted & Indexed in

#ChemicalAbstracts, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, Science Citation Index Expanded® (Sci Search), Index to Scientific Reviews®, Biochemistry & Biophysics Citation Index®, PUBMED, BIOSIS, Journal Citation Reports/Science Edition, EMBASE/ExcerptaMedica, MediaFinder-Standard Periodical Directory, Medline, Scopus, EMBASE, Genamics Journal Seek, PubsHub, and J-Gate.

For details about the latest issues, visit: http://benthamscience.com/journal/index.php?journalID=cdt

 

Current Molecular Imaging, 3 Issue 1

Aims & scope

Current Molecular Imaging publishes peer reviewed expert review articles and special topic issues on all aspects of experimental and clinical research in molecular imaging. Topics include the investigative and practical applications of novel radiopharmaceuticals; standard and complicated imaging methodologies and probes; as well as standard and evolving quantitative approaches.

http://www.eurekaselect.com/124654/issue/1

Abstracted & Indexed in

Chemical Abstracts, J-Gate, PubsHub, and Scopus.

For details about the latest issues, visit: http://benthamscience.com/journal/index.php?journalID=cmi

 

Recent Patents on Anti-Infective Drug Discovery, 9 Issue 1

Aims & scope

Recent Patents on Anti-Infective Drug Discovery publishes review and research articles, drug clinical trial studies and guest edited thematic issues on recent patents in the field of anti-infective drug discovery e.g. on novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery. The journal also covers recent research (where patents have been registered) in fast emerging therapeutic areas/targets & therapeutic agents related to anti-infective drug discovery.

http://www.eurekaselect.com/124637/issue/1

Abstracted & Indexed in

PubMed/Medline, Scopus, EMBASE, METADEX, CAB Abstracts, Cambridge Scientific Abstracts (CSA), Chemical Abstracts, GenamicsJournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, and J-Gate.

For details about the latest issues, visit:http://benthamscience.com/journal/index.php?journalID=rpaidd

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