Press Release for EurekAlert! Solid-phase extraction of ibuprofen from pharmaceuticals

The content of active ingredients in pharmaceuticals is mostly assessed by reversed-phase HPLC. Nevertheless, the excipients in case of suppositories are usually not soluble in commonly used mobile phases solvents (methanol, acetonitrile). That is the reason why a labour intensive and tedious sample pre-treatment is necessary, in order to remove the matrix from the sample.

The presence of Lewis acid sites on the surface of metal oxides is responsible for strong interactions with Lewis bases due to ligand exchange. Although this phenomenon is not desirable in chromatography, these interactions might be employed in a sample pre-treatment based on solid phase extraction.

We newly tested this approach on ibuprofen, which is a favourable drug for the management of pain and fever. Due to the inability of infants to swallow tablets, ibuprofen is often administered in the form of suppositories and oral suspensions in paediatric clinics.

Using the zirconium dioxide as the extraction material, efficient trapping of ibuprofen from a hydrophobic suppository matrix was enabled. It demonstrated the pivotal role of interactions between the carboxylic moiety of ibuprofen and the Lewis acid sites on the zirconia surface. The excellent extraction of ibuprofen was also obtained from the hydrophilic environment, which was tested on an oral suspension. Titania as a second tested material was not capable of trapping ibuprofen from pharmaceuticals efficiently due to its weaker ligand exchange properties.

We have described the first successful utilization of the ligand exchange process on zirconia in the extraction of ibuprofen from hydrophobic as well as hydrophilic media using two different dosages forms. The procedure can be applied in cases where excipients or a drug are not soluble in commonly used HPLC solvents and/or if co-eluting peaks from matrix are an issue. The recoveries of ibuprofen were 95 % and 94 % from suppositories and the oral suspension, respectively.

Reference: Klivický, M.; et al (2016). Solid-Phase Extraction of Ibuprofen from Pharmaceuticals via Ligand Exchange Using Zirconium Dioxide. Curr Anal Chem., DOI: 10.2174/1573411012666151022194146

For more information about the article, please visit: http://benthamscience.com/journals/current-analytical-chemistry/article/135981/

 

 

4th Microbiome R&D and Business Collaboration Forum: Europe

Global Engage is pleased to announce the 4^th Microbiome R&D and Business Collaboration Forum: Europe which will be held on 3-4 April 2017.

For more details visit: http://www.global-engage.com/event/microbiota/

4th Microbiome R&D and Business Collaboration Forum: Europe

Global Engage is pleased to announce the 4^th Microbiome R&D and Business Collaboration Forum: Europe which will be held on 3-4 April 2017.

For more details visit: http://www.globalengage.co.uk/microbiota.html

New Issue :: Pharmaceutical Nanotechnology, 4 Issue 3

Pharmaceutical Nanotechnology publishes original manuscripts, reviews, thematic issues, rapid technical notes and commentaries that provide insights into the synthesis, characterisation and pharmaceutical (or diagnostic) application of materials at the nanoscale. The nanoscale is defined as a size range of below 1 µm. Scientific findings related to micro and macro systems with functionality residing within features defined at the nanoscale are also within the scope of the journal. Manuscripts detailing the synthesis, exhaustive characterisation, biological evaluation, clinical testing and/ or toxicological assessment of nanomaterials are of particular interest to the journal’s readership. Articles should be self contained, centred around a well founded hypothesis and should aim to showcase the pharmaceutical/ diagnostic implications of the nanotechnology approach. Manuscripts should aim, wherever possible, to demonstrate the in vivo impact of any nanotechnological intervention. As reducing a material to the nanoscale is capable of fundamentally altering the material’s properties, the journal’s readership is particularly interested in new characterisation techniques and the advanced properties that originate from this size reduction. Both bottom up and top down approaches to the realisation of nanomaterials lie within the scope of the journal.

Articles from the journal Pharmaceutical Nanotechnology, Volume 4 Issue 3:

 

• Meloxicam-loaded Phospholipid/solutol® HS15 Based Mixed Nanomicelles: Preparation, Characterization, and in vitro Antioxidant Activity
• Fabrication & Characterization of 3D Electrospun Biodegradable Nanofibers for Wound Dressing, Drug Delivery and Other Tissue Engineering Applications
• Experimental Studies on the Systemic Toxicity and Biodistribution of Synthesized Calcium Phosphate Nanoparticles After Oral Administration in Rats
• Development and Comparison of Nanosponge and Niosome based Gel for the Topical Delivery of Tazarotene
• Nanoemulsion for Migraine Prophylaxis Nasal Drug Delivery: Preparation, Characterization and in vitro Evaluation
• Pharmaceutical Nanotechnology United States Patent Watch (April – June 2016)

For details on the articles, please visit this link :: http://bit.ly/2dpfBpN

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Dr. Ismail Murat Palabiyik
Department of Analytical
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University of Ankara
Turkey

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Dr. Iva Bousova, Ph.D.
Dept of Biochemical Sciences
Charles University Prague,
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Heyrovskeho
Czech Republic

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Prof. Dr. Xinyong Liu
Department of Medicinal Chemistry
School of Pharmaceutical Sciences
Shandong University
Shandong, China

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the quality is the hallmark of Bentham Science. I do believe that Drug Delivery Letters
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Roland Institute of Pharmaceutical Sciences,
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India

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Dr. Jinjun Liu
Institute of Chinese Tranditional Medicine,
Chendde Medical College,
Chengde
China

• Current Drug Targets

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Lei Xie, Ph.D.

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Department of Computer Science,

Hunter College
The City University of New York