Press Release for EurekAlert! Solid-phase extraction of ibuprofen from pharmaceuticals


The content of active ingredients in pharmaceuticals is mostly assessed by reversed-phase HPLC. Nevertheless, the excipients in case of suppositories are usually not soluble in commonly used mobile phases solvents (methanol, acetonitrile). That is the reason why a labour intensive and tedious sample pre-treatment is necessary, in order to remove the matrix from the sample.

The presence of Lewis acid sites on the surface of metal oxides is responsible for strong interactions with Lewis bases due to ligand exchange. Although this phenomenon is not desirable in chromatography, these interactions might be employed in a sample pre-treatment based on solid phase extraction.

We newly tested this approach on ibuprofen, which is a favourable drug for the management of pain and fever. Due to the inability of infants to swallow tablets, ibuprofen is often administered in the form of suppositories and oral suspensions in paediatric clinics.

Using the zirconium dioxide as the extraction material, efficient trapping of ibuprofen from a hydrophobic suppository matrix was enabled. It demonstrated the pivotal role of interactions between the carboxylic moiety of ibuprofen and the Lewis acid sites on the zirconia surface. The excellent extraction of ibuprofen was also obtained from the hydrophilic environment, which was tested on an oral suspension. Titania as a second tested material was not capable of trapping ibuprofen from pharmaceuticals efficiently due to its weaker ligand exchange properties.

We have described the first successful utilization of the ligand exchange process on zirconia in the extraction of ibuprofen from hydrophobic as well as hydrophilic media using two different dosages forms. The procedure can be applied in cases where excipients or a drug are not soluble in commonly used HPLC solvents and/or if co-eluting peaks from matrix are an issue. The recoveries of ibuprofen were 95 % and 94 % from suppositories and the oral suspension, respectively.

Reference: Klivický, M.; et al (2016). Solid-Phase Extraction of Ibuprofen from Pharmaceuticals via Ligand Exchange Using Zirconium Dioxide. Curr Anal Chem., DOI: 10.2174/1573411012666151022194146

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4th Microbiome R&D and Business Collaboration Forum: Europe


Global Engage is pleased to announce the 4th Microbiome R&D and Business Collaboration Forum: Europe which will be held on 3-4 April 2017.

For more details visit:

4th Microbiome R&D and Business Collaboration Forum: Europe


Global Engage is pleased to announce the 4th Microbiome R&D and Business Collaboration Forum: Europe which will be held on 3-4 April 2017.

For more details visit:

New Issue :: Pharmaceutical Nanotechnology, 4 Issue 3

Pharmaceutical Nanotechnology publishes original manuscripts, reviews, thematic issues, rapid technical notes and commentaries that provide insights into the synthesis, characterisation and pharmaceutical (or diagnostic) application of materials at the nanoscale. The nanoscale is defined as a size range of below 1 µm. Scientific findings related to micro and macro systems with functionality residing within features defined at the nanoscale are also within the scope of the journal. Manuscripts detailing the synthesis, exhaustive characterisation, biological evaluation, clinical testing and/ or toxicological assessment of nanomaterials are of particular interest to the journal’s readership. Articles should be self contained, centred around a well founded hypothesis and should aim to showcase the pharmaceutical/ diagnostic implications of the nanotechnology approach. Manuscripts should aim, wherever possible, to demonstrate the in vivo impact of any nanotechnological intervention. As reducing a material to the nanoscale is capable of fundamentally altering the material’s properties, the journal’s readership is particularly interested in new characterisation techniques and the advanced properties that originate from this size reduction. Both bottom up and top down approaches to the realisation of nanomaterials lie within the scope of the journal.


Articles from the journal Pharmaceutical Nanotechnology, Volume 4 Issue 3:


For details on the articles, please visit this link ::

Author’s Comments about Bentham Science Publishers!!

• Current Pharmaceutical Analysis

“The publishing procedure at Bentham Science Publishers is fast, efficient and professional. It was a great pleasure for me to publish my work in their journal Current Pharmaceutical Analysis.”

Dr. Ismail Murat Palabiyik

Dr. Ismail Murat Palabiyik
Department of Analytical
Faculty of Pharmacy
University of Ankara

• Current Medicinal Chemistry

“Our article was published in the special issue, “Chemistry and Biology of Antioxidants” of Current Medicinal Chemistry at Bentham Science Publishers. Our experience with the Manager Graphics and Senior Manager Publications was very positive. Both of them were not only professional, effective and helpful but also quite pleasant to work with.”

Dr. Iva Bousova, Ph.D

Dr. Iva Bousova, Ph.D.
Dept of Biochemical Sciences
Charles University Prague,
Faculty of Pharmacy
Czech Republic

• Letters in Drug Design & Discovery

“It has been an excellent experience working with Bentham Science Publishers, where the review process is fast and efficient, and the editorial staff is friendly and helpful. Bentham Science is a great place to publish your research paper, and I look forward to working with them further.”

Dr. Xinyong

Prof. Dr. Xinyong Liu
Department of Medicinal Chemistry
School of Pharmaceutical Sciences
Shandong University
Shandong, China

• Anti-Cancer Agents in Medicinal Chemistry

“I am glad to have my work published in Anti- Cancer Agents in Medicinal Chemistry. I found the publication process to be professional and efficient. The papers are reviewed rapidly and included promptly to PubMed. I highly recommend scientists to submit their papers at Bentham Science Publishers.”

Dr. Vita M. Golubovskaya

Dr. Vita M. Golubovskaya
Department of
Surgical Oncology,
Roswell Park Cancer Institute
Buffalo, NY

• Inflammation & Allergy – Drug Targets:

“I began my experience with Bentham Science Publishers by submitting my review article on the website of Inflammation & Allergy – Drug Targets. I found the website easy to use and needed only a few steps to finish my submission.
I received the first reply in a short time afterwards. After addressing the comments, I resubmitted it. I was surprised by the rapid acceptance after only a week and my review was added online on the journal website in a few days. I found the team to be very helpful and responsive.
I would like to keep working with Bentham Science in future as well. I will soon submit another manuscript on my ongoing project in my lab with them. I recommend Bentham Science to my colleagues as well.”

Mohammed Al-Gayyar, PhDMohammed Al-GayyarAssociate Professor of Clinical Biochemistry
Faculty of Pharmacy University of Mansoura

• Drug Delivery Letters

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submission in Drug Delivery Letters. Speedy processing of articles.
the quality is the hallmark of Bentham Science. I do believe that Drug Delivery Letters
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• Letters in Organic ChemistryDr. Chinam Niranjan Patra
Department of Pharmaceutics,
Roland Institute of Pharmaceutical Sciences,
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“ I sincerely believe that Bentham Science Publishers is just perfect! I can feel a high
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Dr. Jinjun Liu

Dr. Jinjun Liu
Institute of Chinese Tranditional Medicine,
Chendde Medical College,

• Current Drug Targets

“ I had a wonderful experience working with Bentham Science Publishers. I found the
editors to be knowledgeable and quite professional in handling the manuscript. I am glad
to have my research paper in Current Drug Targets to be published timely. Thank you.”

dr.Lei Xie

Lei Xie, Ph.D.

Associate Professor

Department of Computer Science,

Hunter College
The City University of New York

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