EDITOR’S CHOICE ARTICLE – Past and Present of Imaging Modalities Used for Prostate Cancer Diagnosis: Androgen Receptor Targeted Imaging of Prostate Cancer as a Future Modality for Early, Rapid and Efficient Diagnosis

Author(s): Tooba Khaliq, Rashid Rasheed, Dan Cheng, Tao Kong, Le Wang, Saira Azhar,Nazish Jabeen, Yi Lu*, Ghulam Murtaza*.

Graphical Abstract:

 

Abstract:

Background: Prostate cancer is the second most prevailing cancer among men worldwide. In the most cases, prostate cancer is slowly progressing, whereas, in some cases, it is a rapidly progressing disease leading to the significantly high mortality rate. Thus, there is still demand for prostate-specific imaging in order to provide image-guided early diagnosis and for the provision of patient-specific therapy.

Discussion: Besides discussing traditional diagnostic approaches, this review illustrates a perspective on prostate cancer imaging summarizing current imaging approaches with a special focus on Prostate Specific Membrane Antigen (PSMA), Bombesin (BN) and Androgen Receptor (AR) targeted imaging using Positron Emission Tomography (PET) and Single Positron Emission Computed Tomography (SPECT) based on 99mTc and other radiotracers. Here, the prostate biology is reconsidered for nuclear imaging as future modality for early, rapid and efficient diagnosis of prostate cancer.

Conclusion: Future direction in prostate cancer imaging involves the development of androgen receptor based imaging using nonsteroidal antiandrogen agent for early diagnosis of prostate cancer.

 

For more details, please visit: http://www.eurekaselect.com/154253/article

Press Release – Androgen receptor targeted imaging of prostate cancer as future modality for diagnosis

This article by Dr. Ghulam Murtaza et al. is published in Current Medical Imaging Reviews, Volume 13, 2017

Prostate cancer is the second most prevailing cancer among men worldwide. In the most cases, prostate cancer is slowly progressing, whereas, in some cases, it is a rapidly progressing disease with a significantly high mortality rate. Thus, there is still demand for prostate-specific imaging in order to provide image-guided early diagnosis and for provision of patient-specific therapy. Besides discussing traditional diagnostic approaches, this review illustrates a perspective on prostate cancer imaging summarizing current imaging approaches with a special focus on prostate specific membrane antigen (PSMA), bombesin (BN) and androgen receptor (AR) targeted imaging using positron emission tomography (PET) and single positron emission computed tomography (SPECT) based on 99mTc and other radiotracers. Here, the prostate biology is rethought for nuclear imaging as future modality for early, rapid and efficient diagnosis of prostate cancer. Future direction in prostate cancer imaging involves the development of androgen receptor based imaging using nonsteroidal antiandrogen agent for early diagnosis of prostate cancer.

For more information on this research study, please visit: http://www.eurekaselect.com/154253

“Bone Metastases Radiopharmaceuticals: An Overview”

Most Cited Article from the Journal

“Current Radiopharmaceuticals”

1969209_795547127204252_9043461346528902104_nAbstract:

The skeleton is one of the preferential sites for metastases of solid tumors, and metastatic disease is the most common malignancy of the bone. Diagnosis and evaluation of skeletal metastases require more frequently a combined approach of different diagnostic methods. Between the currently available imaging modalities, a major role is devoted to two radionuclide functional techniques namely scintigraphy and positron emission tomography (PET) imaging. Both these techniques require the use of different radiopharmaceuticals. The aim of this paper is to review the most important radiocompounds that can be successfully used to detect and/or characterize bone metastases.

For details, visit: http://benthamscience.com/journals/current-radiopharmaceuticals/volume/6/issue/1/page/41/

Recent Issues of Bentham Science Journals have been Published

Inflammation & Allergy-Drug Targets, 13 Issue 4

Aims & scope

Inflammation & #Allergy – Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in inflammation and allergy e.g. disease specific proteins, receptors, enzymes, genes. The journal publishes expert in-depth reviews, original research articles, drug clinical trial studies and guest edited thematic issues covering a range of current topics on drug targets involved in inflammation and allergy. As the discovery, identification, characterization and validation of novel human drug targets for anti-inflammation and allergy drug discovery continue to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.

http://www.eurekaselect.com/124592/issue/4

Abstracted & Indexed in

Chemical Abstracts, BIOSIS, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, MEDLINE/Index Medicus, EMBASE/ExcerptaMedica, Scopus, PubsHub, GenamicsJournalSeek, MediaFinder®-Standard Periodical Directory, and J-Gate..

For details about the latest issues, visit:http://benthamscience.com/journal/index.php?journalID=iadt

 

Current Topics in Medicinal Chemistry, 14 Issue 14

Aims & scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

http://www.eurekaselect.com/124602/issue/14

Abstracted & Indexed in

BIOSIS, Chemical Abstracts, MEDLINE/Index Medicus, PUBMED, ISI, Science Citation Index ExpandedTM, Biochemistry & Biophysics Citation IndexTM, index to Scientific Reviews®, Current Contents®, EMBASE/ExcerptaMedica, Journal Citation Reports/Science Edition, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, Scopus, GenamicsJournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, and J-Gate.

For details about the latest issues, visit:http://benthamscience.com/journal/index.php?journalID=ctmc

 

Mini-Reviews in Organic Chemistry, 11 Issue 3

Aims & scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

http://www.eurekaselect.com/124555/issue/3

Abstracted & Indexed in

BIOSIS, Chemical Abstracts, MEDLINE/Index Medicus, PUBMED, ISI, Science Citation Index ExpandedTM, Biochemistry & Biophysics Citation IndexTM, index to Scientific Reviews®, Current Contents®, EMBASE/ExcerptaMedica, Journal Citation Reports/Science Edition, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, Scopus, GenamicsJournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, and J-Gate

For details about the latest issues, visit:http://benthamscience.com/journal/index.php?journalID=ctmc

 

Current Inorganic Chemistry, 4 Issue 2

Aims & scope

Current Inorganic #Chemistry, a peer-reviewed journal, publishing original research, review articles and guest edited thematic issues in all areas of inorganic chemistry. The journal’s scope includes the synthesis, crystal structure, physical methods, thermodynamics, reactivity, spectroscopy, electronic and bonding properties of significant new and known (bio) inorganic and organometallic compounds.

Current Inorganic Chemistry is an important and reliable source of information on current developments, research and theory in the field. The emphasis is on publishing high quality articles.

http://www.eurekaselect.com/124573/issue/2

Abstracted & Indexed in

Chemical Abstracts, MediaFinder®-Standard Periodical Directory, and J-Gate.

For details about the latest issues, visit: http://benthamscience.com/journal/index.php?journalID=cic

 

Current Drug Targets, 15 Issue 10

Aims & scope

Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes.

Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication mini- & full-length review articles and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

http://www.eurekaselect.com/124609/issue/10

Abstracted & Indexed in

#ChemicalAbstracts, BIOSIS Previews, BIOSIS Reviews Reports and Meetings, Science Citation Index Expanded® (Sci Search), Index to Scientific Reviews®, Biochemistry & Biophysics Citation Index®, PUBMED, BIOSIS, Journal Citation Reports/Science Edition, EMBASE/ExcerptaMedica, MediaFinder-Standard Periodical Directory, Medline, Scopus, EMBASE, Genamics Journal Seek, PubsHub, and J-Gate.

For details about the latest issues, visit: http://benthamscience.com/journal/index.php?journalID=cdt

 

Current Molecular Imaging, 3 Issue 1

Aims & scope

Current Molecular Imaging publishes peer reviewed expert review articles and special topic issues on all aspects of experimental and clinical research in molecular imaging. Topics include the investigative and practical applications of novel radiopharmaceuticals; standard and complicated imaging methodologies and probes; as well as standard and evolving quantitative approaches.

http://www.eurekaselect.com/124654/issue/1

Abstracted & Indexed in

Chemical Abstracts, J-Gate, PubsHub, and Scopus.

For details about the latest issues, visit: http://benthamscience.com/journal/index.php?journalID=cmi

 

Recent Patents on Anti-Infective Drug Discovery, 9 Issue 1

Aims & scope

Recent Patents on Anti-Infective Drug Discovery publishes review and research articles, drug clinical trial studies and guest edited thematic issues on recent patents in the field of anti-infective drug discovery e.g. on novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery. The journal also covers recent research (where patents have been registered) in fast emerging therapeutic areas/targets & therapeutic agents related to anti-infective drug discovery.

http://www.eurekaselect.com/124637/issue/1

Abstracted & Indexed in

PubMed/Medline, Scopus, EMBASE, METADEX, CAB Abstracts, Cambridge Scientific Abstracts (CSA), Chemical Abstracts, GenamicsJournalSeek, MediaFinder®-Standard Periodical Directory, PubsHub, and J-Gate.

For details about the latest issues, visit:http://benthamscience.com/journal/index.php?journalID=rpaidd

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