Current article: Could Polyphenolic Food Intake Help in the Control of Type 2 Diabetes? A Narrative Review of the Last Evidence

Author(s):Luigi FerraraMarko Joksimovic and Stefania D’Angelo*

Background: Diabetes is one of the most serious global public health concerns, imposing a significant burden on public health and socio-economic development, with type 2 diabetes accounting for 90 percent of individuals with the disease (T2D).

Introduction: Beyond the hereditary factor, there are several risk factors associated with the development of this syndrome; the lifestyle plays an increasingly predominant role in the development of the metabolic complications related to T2D and a significant role in the onset of this syndrome is played by an unbalanced diet. Polyphenolic food is a plant-based food, including vegetables, fruits, whole grains, tea, coffee, and nuts. In recent years, there has been growing evidence that polyphenols, due to their biological properties, may be used as nutraceuticals and supplementary treatments for various aspects of T2D. Polyphenols may influence glycemia and T2D through hypoglycemic properties, such as reduced insulin resistance, reduced fasting blood glucose, and glycosylated hemoglobin value. Based on several in vitro, animal models, and some human studies, it has been detected that polyphenol-rich products modulate carbohydrate and lipid metabolism, attenuate hyperglycemia, dyslipidemia, and insulin resistance, improve adipose tissue metabolism, and alleviate oxidative stress and stress-sensitive signaling pathways and inflammatory processes.

Methods: This manuscript summarizes human clinical trials conducted within the last 5 years linking dietary polyphenols to T2D, with a focus on polyphenolic foods found in the Mediterranean diet.

Results: Intaking polyphenols and their food sources have demonstrated beneficial effects on insulin resistance and other cardiometabolic risk factors. Prospective studies have shown inverse associations between polyphenol intake and T2D. The Mediterranean diet and its key components, olive oil, nuts, and red wine, have been inversely associated with insulin resistance and T2D.

Conclusion: In conclusion, the intake of polyphenols may be beneficial for both insulin resistance and T2D risk. However, other human clinical studies are needed to evaluate the suitable dose and duration of supplementation with polyphenolic food in T2D patients.

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Press Release | Bentham Science announces an important new journal, ‘Coronaviruses’

bentham science news release



Bentham Science announces an important new journal, Coronaviruses to cover the latest research on coronavirus- related outbreak and the methods employed to treat coronavirus infections. Every article in the first issue of the journal will be published as Open Access (Free-to-download) for a limited time period of three months. The Editor-in-Chief of the journal is Prof. D. Liu at the Wuhan Institute of Virology, Wuhan , China, a world leading institution on virus research. The Honorary Editors of the journal are Prof. Ferid Murad (Nobel Laureate) and Prof. Atta-Ur-Rahman, FRS (Academician Chinese Academy of Sciences, and UNESCO Science Laureate).

Coronaviruses will publish original research articles, letters, reviews/mini-reviews and guest edited thematic issues on all aspects of coronaviruses such as their origins, types, transmission, pathogenesis, epidemiological, demographic, clinical and genomic characteristics etc. The Journal will also cover case reports and studies on outbreak of coronaviruses, their symptoms, related diseases, prevention, treatment regimens and development of new drugs.

The journal will be essential reading for virologists, epidemiologists, microbiologists and healthcare workers interested in the latest information about coronaviridae. Visit the journal website for further details:


Read full Press Release to find out more:

Join the Editorial Board | Coronaviruses






“NEW IN 2020”


Bentham Science is interested in appointing active Editorial Board Members for  the journal; Coronaviruses. If you are working in the related field of the journal and are interested in becoming an Editorial Board Member, please send us your CV and a list of publications. You can also recommend suitable colleagues for the same, and, if possible, send their CV along with their list of publications. 


Mention in the subject line the field of interest, and send your CV at: and




Coronaviruses publishes original research articles, letters, reviews/mini-reviews, clinical trial and guest edited thematic issues on all aspects of coronaviruses such as their origins, types, transmission, pathogenesis, epidemiological, demographic, clinical and genomic characteristics etc.

The Journal also covers case reports and studies on outbreak of coronaviruses, their symptoms, related diseases, prevention, treatment and development of new therapeutics.

To know more about the journal, please visit:

MOST ACCESSED ARTICLE – Polyphenols: Potential Use in the Prevention and Treatment of Cardiovascular Diseases

Journal Name: Current Pharmaceutical Design

Author(s): Rosaria Vincenza Giglio, Angelo Maria Patti, Arrigo F.G. Cicero, Giuseppe Lippi, Manfredi Rizzo*, Peter P. Toth, Maciej Banach.





Background: Polyphenols are bioactive compounds that can be found mostly in foods like fruits, cereals, vegetables, dry legumes, chocolate and beverages such as coffee, tea and wine. They are extensively used in the prevention and treatment of cardiovascular disease (CVD) providing protection against many chronic illnesses. Their effects on human health depend on the amount consumed and on their bioavailability. Many studies have demonstrated that polyphenols have also good effects on the vascular system by lowering blood pressure, improving endothelial function, increasing antioxidant defences, inhibiting platelet aggregation and low-density lipoprotein oxidation, and reducing inflammatory responses.

Methods: This review is focused on some groups of polyphenols and their effects on several cardiovascular risk factors such as hypertension, oxidative stress, atherogenesis, endothelial dysfunction, carotid artery intima-media thickness, diabetes and lipid disorders.

Results: It is proved that these compounds have many cardio protective functions: they alter hepatic cholesterol absorption, triglyceride biosynthesis and lipoprotein secretion, the processing of lipoproteins in plasma, and inflammation. In some cases, human long-term studies did not show conclusive results because they lacked in appropriate controls and in an undefined polyphenol dosing regimen.

Conclusion: Rigorous evidence is necessary to demonstrate whether or not polyphenols beneficially impact CVD prevention and treatment.




Bentham Science is attending  AACR Annual Meeting 2018 held on 14 – 18 April 2018 in Chicago,Illionois. Meet us at Booth no. 1437 and view our range of publications.

AACR Annual Meeting 2018

The mission of the American Association for Cancer Research is to prevent and cure cancer through research, education, communication, and collaboration. Through its programs and services, the AACR fosters research in cancer and related biomedical science; accelerates the dissemination of new research findings among scientists and others dedicated to the conquest of cancer; promotes science education and training; and advances the understanding of cancer etiology, prevention, diagnosis, and treatment throughout the world.

Testimonial by Liliya Vasileva!

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Contributed Article: “Current And Emerging Strategies in Osteoporosis Management

World Osteoporosis Day 2017!


World Osteoporosis Day takes place every year on October 20, launching a year-long campaign dedicated to raising global awareness of the prevention, diagnosis and treatment of osteoporosis and metabolic bone disease.

Bentham Science Publishers has various research articles dedicated to the Osteoporosis and bone diseases that can be found in the following journal:

Current Rheumatology Reviews

To Avail 20% Discount on related eBooks, kindly visit:

Rabies: Zero by 2030

Rabies is a transmittable viral illness that nearly always results in death after the beginning of clinical symptoms. In majority of cases, home-bred dogs are to be blamed for spreading the virus to humans, although both domestic and feral animals can be carriers of the disease. It is transmitted to humans through saliva of affected animals when they bite. Although rabies is a completely avoidable disease, it still causes several deaths everyday around the globe.


World Rabies Day is observed as the universal day of action and recognition for the prevention of rabies. World Rabies Day, on September 28, is a worldwide health initiative introduced in 2007 to increase awareness regarding the affliction of rabies and unite to boost prevention internationally. This very date is the death anniversary of Louis Pasteur, the French chemist and microbiologist, who invented the first rabies injection.

At the international meeting on rabies eradication in 2015, a joint objective of zero human mortality from canine rabies by 2030 was decided upon by the World Health Organization, World Organisation for Animal Health, UN Food and Agriculture Organization and GARC.  In assistance of this target, the theme of 2017 World Rabies Day is Rabies: Zero by 30. It is now everyone’s job to make eradication of rabies an actuality. World Rabies Day is a chance to do your bit in ending the avoidable misery and fatalities caused by rabies. One of the basic steps to assist in the avoidance and control of rabies is by inoculating your pets and educating yourself about how to avoid animals that generally spread rabies: dogs, raccoons, bats, skunks, and foxes.

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