New Issue | Protein & Peptide Letters; Volume 26 Issue 6

Protein & Peptide Letters publishes letters, original research papers, mini-reviews and guest edited issues in all important aspects of protein and peptide research, including structural studies, advances in recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, and drug design. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallization and preliminary structure determination of biologically important proteins are considered only if they include significant new approaches or deal with proteins of immediate importance, and preliminary structure determinations of biologically important proteins. Purely theoretical/review papers should provide new insight into the principles of protein/peptide structure and function. Manuscripts describing computational work should include some experimental data to provide confirmation of the results of calculations.

Protein & Peptide Letters focuses on:

Structure Studies Advances in Recombinant Expression Drug Design Chemical Synthesis Function Pharmacology Enzymology Conformational Analysis

Immunology Biotechnology Protein Engineering Protein Folding Sequencing Molecular Recognition Purification and Analysis

 

Articles from the journal: Protein & Peptide Letters; Volume 26 Issue 6

• Investigation of Potential Paraoxonase-I Inhibitors by Kinetic and Molecular Docking Studies: Chemotherapeutic Drugs
• Structure – Function Analysis of Peptide Analogs of SQSPA with Respect to α-glucosidase and α-amylase Inhibition
• Characteristics and Function of the Chitin Binding Protein from Xenorhabdus nematophila
• Synthesis and SAR Studies of Antibacterial Peptidyl Derivatives Based upon the Binding Site of Human Cystatin C
• Spectroscopic Studies of Asparaginyl-tRNA Synthetase from Entamoeba histolytica
• Expression and Solution NMR Study of Multi-site Phosphomimetic Mutant BCL-2 Protein
• Human Epididymis Protein 4 Quantification and Interaction Network Analysis in Seminal Plasma

For details on the articles, please visit this link: http://www.eurekaselect.com/node/628/protein-peptide-letters/issue/26/2610/6/9188

Aims & Scope | Protein & Peptide Letters

Aims & Scope

 

Protein & Peptide Letters publishes letters, original research papers, mini-reviews and guest edited issues in all important aspects of protein and peptide research, including structural studies, advances in recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, and drug design. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallization and preliminary structure determination of biologically important proteins are considered only if they include significant new approaches or deal with proteins of immediate importance, and preliminary structure determinations of biologically important proteins. Purely theoretical/review papers should provide new insight into the principles of protein/peptide structure and function. Manuscripts describing computational work should include some experimental data to provide confirmation of the results of calculations.

Protein & Peptide Letters focuses on:

Structure Studies Advances in Recombinant Expression Drug Design Chemical Synthesis Function Pharmacology Enzymology Conformational Analysis

Immunology Biotechnology Protein Engineering Protein Folding Sequencing Molecular Recognition Purification and Analysis

 

 

Read out more at:  https://benthamscience.com/journals/protein-and-peptide-letters/aims-scope/#top

Most Accessed Articles | Insights into the Noncoding RNA-encoded Peptides

Journal Name: Protein & Peptide Letters

Author(s): Jinchang Pan, Xiaodan Meng, Nan Jiang, Xiaofeng Jin, Chengwei Zhou, Dazhi Xu, Zhaohui Gong*.

Graphical Abstract:

Abstract:

Background: Considerable evidence has indicated that most noncoding RNA (ncRNA) transcripts act directly as functional RNAs rather than as encoded peptides. However, a recent study of ribosome occupancy reported that many large intergenic ncRNAs (lincRNAs) are bound by ribosomes, raising the possibility that they are translated into proteins. These lincRNAs contain either Internal Ribosomal Entry Sites (IRES) or short Open Reading Frames (sORFs), and other translation elements, which can be translated into peptides with physiological functions.

Conclusion: This review discusses three major types of ncRNA-encoded peptides (ncPEPs). First, microRNA(miRNA)-encoded peptides (miPEPs) are translated from their primary transcripts of miRNA genes and can promote the development of plant roots. Second, a long ncRNA(lncRNA) containing sORF encodes a 90 residues long regulatory peptide. Upon the amino acid response, the lncRNA-encoded peptide reduces the activity of mammalian Target Rapamycin complex 1 (mTORC1) and promotes muscle regeneration. Third, a circular RNA (circRNA) of the Na+/Ca2+ exchanger gene 1 (NCX1) exon 2 transcript encodes a truncated NCX1 protein exhibiting the Na+/Ca2+ exchange activity. It is also of worth noting that the majority of ncRNAs is not translated. This review summarizes the current understanding of the translatability of ncRNAs and the functions of ncPEPs in cellular processes, which may provide novel insights into the roles of ncPEPs.

 

 

Read out more at: http://www.eurekaselect.com/164529

Open Access Articles | An Overview of Current Methods to Confirm Protein-Protein Interactions

Journal Name: Protein & Peptide Letters

Author(s): Kenji Miura*.

 

 

 

Graphical Abstract:

 

 

Abstract:

Background: The research field of protein-protein interactions is interdisciplinary and specialized field that spans all aspects of biology, physics and chemistry. Therefore, in order to discuss the protein-protein interaction in detail and rigorously, it is desirable to integrate knowledge and methods of many related fields including boundary areas such as biochemistry, biophysics and physical chemistry in addition to biology, physics and chemistry.

Objective: The purpose of this review is to overview current methods to confirm protein-protein interactions. Furthermore, I discuss future prospects of methodology based on current status.

Results: It is often necessary to integrate, combine and validate multiple results from various methods to understand protein-protein interactions in detail.

Conclusion: It might be desirable for the addition of tags, labeling, and immobilization to solid phases to be unnecessary, and to obtain information on affinity, kinetics, and structure via the analytical method for protein-protein interactions. Therefore, I argue that novel methods based on principles that have already been sufficiently studied in physics or chemistry, but insufficiently applied to the life sciences, should be established to further develop the study of protein-protein interactions.

 

 

Read out more at:  http://www.eurekaselect.com/164836

Editor’s Choice Article | Serum Proteome Profiling to Identify Proteins Promoting Pathogenesis of Non-atopic Asthma

Journal Name: Protein & Peptide Letters

Author(s): Samina Ejaz, Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Bahawalpur, Pakistan Faiz-ul-Hassan Nasim*, Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan Muhammad Ashraf, Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan Sami Ahmad. Department of Pulmonolgy, Quaid-i-Azam Medical College, Bahawal Victoria Hospital, Bahawalpur, Pakistan

Graphical Abstract:

 

Abstract:

Background: Asthma is the inflammatory disorder of airways highly prevalent in both, children and adults all over the world. The aim of this study was to investigate the serum proteome for the identification of proteins contributing to the pathogenesis of non-atopic asthma.

Methods: Protein expression profiling of sera from non-atopic asthmatic patients (n=73) and controls (n=99) was carried out using 1D SDS PAGE. Differentially expressed protein bands were compared with controls, cut from the gel and identified by LC-Q-TOF_MSMS analysis.

Results: Various acute phase proteins (i.e., haptoglobin, transthyretin, serum amyloid A, and serum albumin), retinol binding protein 4 (RBP4), Ig gamma-1-chain C-region, hemoglobin subunit β, complement system components (C8 gamma chain and C4-A), ApoA-1 and Ig κ chain C-region containing protein fractions were predominantly down-regulated in asthmatic patients. Similarly, a higher proportion of male patients exhibited down-regulation of all other (except albumin and C4-A containing) protein fractions as compared to female patients. However, fractions consisting of another acute phase protein, inter-alpha-trypsin heavy chain 4 (ITIH4) and complement system component C3 were up-regulated in the majority of patients.

Conclusion: Our study is the first to confirm the role of thyroxine (TTR), retinol (RBP4), cholesterol (apoA-1) transporting proteins, inflammation and its mediators in the pathogenesis of asthma. Further study may help to improve diagnosis and plan better treatment strategies.

 

 

Read out more at: http://www.eurekaselect.com/165657/article

 

 

New Issue :: Protein & Peptide Letters (Volume: 25, Issue: 7)

 

Protein & Peptide Letters publishes letters, original research papers, mini-reviews and guest edited issues in all important aspects of protein and peptide research, including structural studies, advances in recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, and drug design. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallization and preliminary structure determination of biologically important proteins are considered only if they include significant new approaches or deal with proteins of immediate importance, and preliminary structure determinations of biologically important proteins.

 

Articles from the journal Protein & Peptide Letters Volume 25, Issue 7:

• Meet Our Editorial Board Member
• Advances in Usage of Venom Proteins as Diagnostics and Therapeutic Mediators
• Phosphodiesterases (PDEs) from Snake Venoms: Therapeutic Applications
• Potential Uses of Venom Proteins in Treatment of HIV
• Snake Venom as an Effective Tool Against Colorectal Cancer
• Potential Application of Venom Proteins in Designing of Medicines for Treating Human Neurodegenerative Disorders
• Venom Protein C Activators as Diagnostic Agents for Defects of Protein C System
• Simulation Studies and Dynamic Interaction of Venom Peptides with Ion Channels
• Hyaluronidases: A Therapeutic Enzyme
• Potential Applications of Venom Peptides as Anti-Thrombotic Agents for Management of Arterial and Deep-Vein Thrombosis
• Applications of Venom Proteins as Potential Anticancer Agents
• Scorpion Venom Peptides as a Potential Source for Human Drug Candidates
• Corrigendum: Utilization of Proteins and Peptides to Create Organic-Hydroxyapatite Hybrids

 

For details on the articles, please visit this link ::  https://bit.ly/2OO6Zdr

EDITOR’S CHOICE – Mammalian Sperm Protamine Extraction and Analysis: A Step-By-Step Detailed Protocol and Brief Review of Protamine Alterations.

JOURNAL: Protein & Peptide Letters

AUTHOR(S): Ada Soler-Ventura, Judit Castillo, Alberto de la Iglesia, Meritxell Jodar, Ferran Barrachina, Josep Lluis Ballesca, Rafael Oliva*.

 

Abstract:

Background: Protamines are the most abundant sperm nuclear proteins and pack approximately the 92-98% of the mammalian sperm DNA. In mammals, two types of protamines have been described, the Protamine 1 (P1) and the Protamine 2 (P2) family. The deregulation of the relative P1/P2 ratio has been correlated to DNA damage, alterations in seminal parameters, and low success rate of assisted reproduction techniques. Additionally, the extraction and analysis of protamines have been important to understand the fundamental aspects of the sperm chromatin structure and function, protamine sequence conservation among species, and sperm chromatin alterations present in infertile males. However, protamines show a particular chemical nature due to its special amino acid sequence, extremely rich in arginine and cysteine residues. Because of these peculiar characteristics of protamines, their extraction and analysis is not as straightforward as the analysis of other chromatin-associated proteins, for which many detailed protocols are already available.

Conclusion: A step-by-step protocol was needed to facilitate protamine analysis to researchers interested in their implementation. Therefore, in order to contribute to fulfill this need, here we provide a detailed protocol, which should be useful to research teams and laboratories interested in the protamine field. In addition, we also briefly review the different studies published so far on protamine alterations and male infertility.

 

Read more here: http://www.eurekaselect.com/161240/article

 

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WISHING A VERY HAPPY BIRTHDAY TO PROF. BEN M. DUNN!

PROF. BEN M. DUNN

EDITOR-IN-CHIEF: CURRENT PROTEIN & PEPTIDE SCIENCE & PROTEIN & PEPTIDE LETTERS

DEPARTMENT OF BIOCHEMISTRY AND MOLECULAR BIOLOGY,
UNIVERSITY OF FLORIDA, COLLEGE OF MEDICINE
P.O. BOX 100245, GAINESVILLE FLORIDA,
USA

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