Editors choice: How to Optimize the Effectiveness and Safety of Parkinson’s Disease Therapy? – A Systematic Review of Drugs Interactions with Food and Dietary Supplements

Author(s): Wiesner AgnieszkaPaśko Paweł and Kujawska Małgorzata*

Background: Despite increasing worldwide incidence of Parkinson’s disease, the therapy is still suboptimal due to the diversified clinical manifestations, lack of sufficient treatment, the poor adherence in advanced patients, and varied response. Proper intake of medications regarding food and managing drug-food interactions may optimize Parkinson’s disease treatment.

Objectives: We investigated potential effects that food, beverages, and dietary supplements may have on the pharmacokinetics and pharmacodynamics of drugs used by parkinsonian patients; identified the most probable interactions; and shaped recommendations for the optimal intake of drugs regarding food.

Methods: We performed a systematic review in adherence to PRISMA guidelines, and included a total of 81 studies in the qualitative synthesis.

Results and Conclusion: We found evidence for levodopa positive interaction with coffee, fiber and vitamin C, as well as for the potential beneficial impact of low-fat and protein redistribution diet. Contrastingly, high-protein diet and ferrous sulfate supplements can negatively affect levodopa pharmacokinetics and effectiveness. For other drugs, the data of food impact are scarce. Based on the available limited evidence, all dopamine agonists (bromocriptine, cabergoline, ropinirole), tolcapone, rasagiline, selegiline in tablets, safinamide, amantadine and pimavanserin can be taken with or without a meal. Opicapone and orally disintegrating selegiline tablets should be administered on an empty stomach. Of monoamine oxidase B inhibitors, safinamide is the least susceptible for interaction with the tyramine-rich food, whereas selegiline and rasagiline may lose selectivity to monoamine oxidase B when administered in supratherapeutic doses. The level of presented evidence is low due to the poor studies design, their insufficient actuality, and missing data.

Learn more: http://bit.ly/3GU98lK

Protein Misfolding Diseases and Therapeutic Approaches

Kusum Yadav, Anurag Yadav, Priyanka Vashistha, Veda P. Pandey, Upendra N. Dwivedi

What is it about?

Protein folding is the process by which a polypeptide chain acquires its functional, native 3D structure. Protein misfolding, on the other hand, is a process in which protein fails to fold into its native functional conformation. This misfolding of proteins may lead to precipitation of a number of serious diseases such as cystic fibrosis (CF), Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) etc. Protein quality-control (PQC) systems, consisting of molecular chaperones, proteases and regulatory factors, help in protein folding and prevent its aggregation. At the same time, PQC systems also do sorting and removal of improperly folded polypeptides. Among the major types of PQC systems involved in protein homeostasis are cytosolic, endoplasmic reticulum (ER) and mitochondrial ones. The cytosol PQC system includes a large number of component chaperones, such as nascent-polypeptide-associated complex (NAC), Hsp40, Hsp70, prefoldin and T Complex Protein-1 (TCP-1) ring complex (TRiC). Protein misfolding diseases caused due to defective cytosolic PQC system include diseases involving keratin/collagen proteins, cardiomyopathies, phenylketonuria, PD and ALS. The components of PQC system of endoplasmic reticulum (ER) include Binding immunoglobulin Protein (BiP), calnexin (CNX), calreticulin (CRT), glucose-regulated protein GRP94, the thioldisulphide oxidoreductases, protein disulphide isomerase (PDI) and ERp57. ER-linked misfolding diseases include CF and familial neurohypophyseal diabetes insipidus (FNDI). The components of mitochondrial PQC system include mitochondrial chaperones such as the Hsp70, the Hsp60/Hsp10 and a set of proteases having AAA+ domains similar to the proteasome that are situated in the matrix or the inner membrane. Protein misfolding diseases caused due to defective mitochondrial PQC system include medium-chain acyl-CoA dehydrogenase (MCAD)/short-chain acyl-CoA dehydrogenase (SCAD) deficiency diseases, hereditary spastic paraplegia. Among therapeutic approaches towards the treatment of various protein misfolding diseases, chaperones have been suggested as potential therapeutic molecules for target based treatment. Chaperones have been advantageous because of their efficient entry and distribution inside the cells, including specific cellular compartments, in therapeutic concentrations. Based on the chemical nature of the chaperones used for therapeutic purposes, molecular, chemical and pharmacological classes of chaperones have been discussed.

Why is it important?

The review is important to better understand the mechanism of protein misfolding for building strategies for curing age related and other diseases. Read now: https://bit.ly/3Pc1Wmt

Podcast – The Role of Vitamin D and Sunlight Incidence in Cancer.

Podcast by Dr. Alice Câmara – May 19, 2020

A study aimed to review the relationship between VD deficiency and cancer: http://www.eurekaselect.com/170650/article

Subscribe to our YouTube channel for more: https://bit.ly/1lr0czy

EDITORS CHOICE ARTICLE – Antitumor Potential of Marine Natural Products: A Mechanistic Investigation

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

Author(s): Liping Hu, Jie Ying, Miaomiao Zhang, Xiaoyan Qiu, Yu Lu*.

 

 

Graphical Abstract:

 

Abstract:

Background: Compounds obtained from natural resources have become important candidates in the discovery and development of drugs. Over the past few decades, marine resources have gradually attracted a large amount of attention from researchers, and many compounds with varying structures and activities have been derived from various marine resources. Since the ocean experiences more variable temperatures, lower oxygen levels and less light than the terrestrial environment, marine resources offer a substantial number of organisms that are not available or rarely detected on land.

Description: Researchers expect that they can discover agents from marine organisms that exhibit good activity for diseases. Of the marine compounds acquired, the majority have shown to have good antitumor activity, and range in phases from clinical trials up to being used in the clinic. These natural products operate through different pathways and have unique antitumor effects that include inducing cell apoptosis, inhibiting cell proliferation and influencing cell migration. A variety of drugs have been used for cancer treatment during the last few years, but it has not been possible to greatly extend the survival time of advanced cancer patients. In addition, researchers are actively looking for compounds to overcome problems that include a lack of effective drugs to control the transfer of cancer cells and the development of drug-resistant microbes.

Conclusion: Here, we summarize the marine natural products that have been obtained over the past few years, and analyze their antitumor effects and mechanisms. Our research will provide a significant basis for anticancer drug screening and development.

 

READ MORE HERE:  http://www.eurekaselect.com/155671/article

Highlighted Article Flyer for the journal “Current Proteomics”

CP-Articles_13-2- Jun-Wang

http://benthamscience.com/journals/current-proteomics/

Enjoy Your Shrimps – Rich In Taste & Also Health!!

Ask me, I am crazy for shrimps, be it in any form – fried, in curries or made with rice. But I often come across people who dislike shrimps so much that they claim to have never even tasted the delicacy. With all such folks I’d like to share the health benefits they can get with adding shrimps to their diet.

can-dogs-eat-shrimp

Shrimps are very rich in protein and are preferably recommended for fulfilling our muscles’ needs. They are far better than red meat, as they are known to carry fewer bacteria. Shrimps are also free from saturated fats which cause trouble in our body. The little amount of unsaturated fat present is good for us.

Shrimps are essentially rich in minerals. Though, it carries a lot of sodium which can be troublesome for people with blood pressure issues.

High-Protein Diet Helps Diabetics

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Obese people with diabetes are able to lose weight on high-protein diets and see improvement in both cardiovascular and renal health, without facing increased risks, according to new research reported by Medical Xpress

The study, conducted by University of Adelaide PhD student Eva Pedersen, compared the effects of a high-protein and standard diet in a year-long study involving 45 obese people with Type 2 diabetes.

The results show that weight loss achieved by both diets resulted in a range of benefits for the participants.
“High-protein diets are commonly used in our community, but concerns have been raised about the potential harmful effects of these diets on diabetic people’s renal function, which is often already compromised due to their condition,” said Peter Clifton, affiliate professor at the University of Adelaide’s School of Medicine and Eva Pedersen’s supervisor.

Within the first six months of the study, both diets helped the participants to lose weight, with almost 9 percent of body weight lost by those on the high-protein diet and more than 6 percent by those on the standard diet.

“Far from seeing any problems caused by the high-protein diet, the participants’ weight loss resulted in improvements to their renal health, as well as to their overall cardiovascular health and the control of their blood-sugar levels,” said Clifton.

Read Latest Breaking News from Newsmax.com http://www.newsmaxhealth.com/Health-News/high-protein-diet-diabetes/2014/01/15/id/547308#ixzz2rHx9mVfS 

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