New Issue :: Current Medicinal Chemistry 24, Issue 7

Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

Articles from the journal Current Medicinal Chemistry 24, Issue 7:

• Human Host Defense Peptides – Role in Maintaining Human Homeostasis and Pathological Processes
• PDE7-Selective and Dual Inhibitors: Advances in Chemical and Biological Research
• A Brief Review of Drug Discovery Research for Human African Trypanosomiasis
• Scutellarin Attenuates Microglia-Mediated Neuroinflammation and Promotes Astrogliosis in Cerebral Ischemia – A Therapeutic Consideration
• Current Strategies in the Modification of PLGA-based Gene Delivery System

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New Issue :: Current Proteomics 14, Issue 2

Research in the emerging field of proteomics is growing at an extremely rapid rate. The principal aim of Current Proteomics is to publish well-timed review articles in this fast-expanding area on topics relevant and significant to the development of proteomics. Current Proteomics is an essential journal for everyone involved in proteomics and related fields in both academia and industry.

Current Proteomics publishes review articles in all aspects of the fast-expanding field of proteomics. All areas of proteomics are covered together with the methodology, softwares, databases, technological advances and applications of proteomics, including functional proteomics.

Articles from the journal Current Proteomics 14, Issue 2:

• The Quest for Novel Biomarkers in Early Diagnosis of Diabetic Neuropathy
• Surface-Enhanced Laser Desorption/Ionization Mass Spectrometry for Biomarker Discovery in Cutaneous Melanoma
• In Silico Study of Different Signal Peptides for Secretory Production of Interleukin-11 in Escherichia coli
• Comparative Study and Classification of Human Chemokine Receptors
• Identification of Osteoporosis-Associated Protein Biomarkers from Ovariectomized Rat Urine
• Proteomic Analysis of Mitochondrial Proteins on the Mechanism of Apoptotic Under Amorphophallus konjac Tuber (KONJAC) Extracts in Gas tric Cancer Cell
• Analysis of DNA Damage-Binding Proteins (DDBs) in Arabidopsis thalian a and their Protection of the Plant from UV Radiation
• Unveiling the Transient Protein-Protein Interactions that Modulate the Activity of Estrogen Receptor(ER)-α by Human Lemur Tyrosine Kinase-3 (LMTK3) Domain: An In Silico Study

For details on the articles, please visit this link :: http://bit.ly/2vB39dJ

 

New Issue :: Current Vascular Pharmacology 15, Issue 3

Current Vascular Pharmacology publishes clinical and research-based reviews, original research articles, letters, debates, drug clinical trial studies and guest edited issues to update all those concerned with the treatment of vascular disease, bridging the gap between clinical practice and ongoing research.

Vascular disease is the commonest cause of death in Westernized countries and its incidence is on the increase in developing countries. It follows that considerable research is directed at establishing effective treatment for acute vascular events. Long-term treatment has also received considerable attention (e.g. for symptomatic relief). Furthermore, effective prevention, whether primary or secondary, is backed by the findings of several landmark trials. Vascular disease is a complex field with primary care physicians and nurse practitioners as well as several specialties involved. The latter include cardiology, vascular and cardio thoracic surgery, general medicine, radiology, clinical pharmacology and neurology (stroke units).

Articles from the journal Current Vascular Pharmacology 15, Issue 3:

• Cartilage Oligomeric Matrix Protein: Matricellular and Matricrine Signaling in Cardiovascular Homeostasis and Disease
• Pregnancy-Associated Plasma Protein-A and its Role in Cardiovascular Disease. Biology, Experimental/Clinical Evidences and Potential Therapeutic Approaches
• Platelets and Platelet-Derived Microvesicles as Immune Effectors in Type 2 Diabetes
• Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists in the Treatment of Obese Women with Polycystic Ovary Syndrome
• Should We be Concerned About the Inflammatory Response to Endovascular Procedures?
• Diagnosis and Treatment of Dyslipidaemias in Athletes
• Indicators of Cardiovascular Risk in Metabolic Syndrome: Long Term Follow-up in Italian Patients
• Comparison of Biolimus Versus Everolimus for Drug-Eluting Stents in the Percutaneous Treatment of Infra-Inguinal Arterial Disease
• Functional Upregulation of STIM-1/Orai-1-Mediated Store-Operated Ca2+ Contributing to the Hypertension Development Elicited by Chronic EtOH Consumption
• Beneficial Effects of Sildenafil on Tissue Perfusion and Inflammation in a Murine Model of Limb Ischemia and Atherosclerosis

For details on the articles, please visit this link :: http://bit.ly/2u0DUSN

New Issue :: Mini-Reviews in Medicinal Chemistry 17, Issue 7

The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

Articles from the journal Mini-Reviews in Medicinal Chemistry 17, Issue 7:

• Fluparoxan: A Comprehensive Review of its Discovery, Adrenergic and CNS Activity and Treatment of Cognitive Dysfunction in Central Neurodegenerative Diseases
• Proteinases as Biomarkers in Breast Cancer Prognosis and Diagnosis
• Evolving Novel Chemical Entities for Management of Benign Prostatic Hyperplasia#
• Secondary Metabolites from Acremonium Fungi: Diverse Structures and Bioactivities
• Molecular Dynamics Simulation Study of the HIV-1 Protease Inhibit ion Using Fullerene and New Fullerene Derivatives of Carbon Nanostructures

For details on the articles, please visit this link :: http://bit.ly/2ti3QMD

 

 

 

 

 

New Issue :: Current Drug Metabolism 18, Issue 4

Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; bioactivation, recent developments for the identification of drug metabolites, adducts and preclinical and clinical summaries of marketed drugs.

Articles from the journal Current Drug Metabolism 18, Issue 4:

• Cancer Nanotechnology: Recent Trends and Developments in Strategies for Targeting Cancer Cells to Improve Cancer Imaging and Treatment
• Past, Recent Progresses and Future Perspectives of Nanotechnology Applied to Antifungal Agents
• Studies on the Metabolism of Nitrogen Compounds by Prof J. W. Gorrod
• Vasopressin and Related Peptides; Potential Value in Diagnosis, Prognosis and Treatment of Clinical Disorders
• Pancreatic Cancer Therapy Review: From Classic Therapeutic Agents to Modern Nanotechnologies

For details on the articles, please visit this link :: http://bit.ly/2t6sBv0

 

 

 

New Issue :: Anti-Cancer Agents in Medicinal Chemistry 17, Issue 4

Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.

Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication.

Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.

Articles from the journal Anti-Cancer Agents in Medicinal Chemistry 17, Issue 4:

• Metastatic Cell Dormancy and Re-activation: An Overview on Series of Molecular Events Critical for Cancer Relapse
• NF-κB Signaling Pathway Inhibitors as Anticancer Drug Candidates
• Triple Negative Breast Cancer: A Tale of Two Decades
• Human Cancer Cell Line Based Approach of 1,3,4-thiadiazole and its Fused Ring: A Comprehensive Review
• Hydroxy Cinnamic Acid Derivatives as Partial PPARγ Agonists: In silico Studies, Synthesis and Biological Characterization Against Chronic Myeloid Leukemia Cell Line (K562)
• Docetaxel-loaded Bovine Serum Albumin Nanoparticles Conjugated Docosahexaenoic Acid for Inhibiting Lung Cancer Metastasis to Bone
• Application of GA-MLR for QSAR Modeling of the Arylthioindole Class of Tubulin Polymerization Inhibitors as Anticancer Agents
• A 3D-QSAR Study on Betulinic Acid Derivatives as Anti-Tumor Agents and the Synthesis of Novel Derivatives for Modeling Validation
• 4-Methylumbelliferones Analogues as Anticancer Agents: Synthesis and in Cell Pharmacological Studies
• Colorectal, Prostate and Pancreas Human Cancers Targeted Bioassay-guided Isolations and Characterization of Chemical Constituents from Tephrosia apollinea
• Y-shaped Folic Acid-Conjugated PEG-PCL Copolymeric Micelles for Delivery of Curcumin
• Hybrid Benzoxazole-Coumarin Compounds Induce Death Receptor-Mediated Switchable Apoptotic and Necroptotic Cell Death on HN-5 Head and Neck Cancer Cell Line
• Physico-chemical and Biological Evaluation of Flavonols: Fisetin, Quercetin and Kaempferol Alone and Incorporated in beta Cyclodextrins
• Phytochemical Analysis with Antioxidant and Cytotoxicity Studies of the Bioactive Principles from Zanthoxylum capense (Small Knobwood)
• Construction of an Anticancer Fusion Peptide (ACFP) Derived from Milk Proteins and an Assay of Anti-ovarian Cancer Cells in vitro
  

For details on the articles, please visit this link :: http://bit.ly/2uh0hWU

 

New Issue :: Recent Patents on Mechanical Engineering 10, Issue 1

Recent Patents on Mechanical Engineering publishes review and research articles, and guest edited thematic issues on recent patents in the field of mechanical engineering. A selection of important and recent patents on mechanical engineering is also included in the journal. The journal is essential reading for all researchers involved in mechanical engineering. The journal also covers recent research (where patents have been registered) in fast emerging analytical methods, designs, manufacturing and analysis of automobiles, aircrafts, manufacturing plants, industrial instruments, machines, heating and cooling systems and processes involved and related to mechanical engineering.

Articles from the journal Recent Patents on Mechanical Engineering 10, Issue 1:

• Recent Patents on Active Self-Ligating Brackets for Orthodontic Treatment
• Recent Advances on Rapeseed Metering Devices
• Advanced Technology in GIS/GPS-Based Transportation Systems
• Recent Advances in Driverless Car
• Research Status on Frictional Vibration and Noise of Mechanical Brake
• Flow Analysis and Experimental Investigation on Micro Electrochemical Drilling of Deep Micro-Holes
• A Novel Multiple High-Pressure Water-Jets Assisted Cutting Head in Rock Fragmentation
• Study about the Effect of System Parameters on the Dynamic Properties of Hydraulic Buffer System Applied to Belt Arrestor for Downward Belt Conveyor
• A Method for Patent Mining and Its Application in Innovation of High-Altitude Cleaning Robot

For details on the articles, please visit this link :: http://bit.ly/2tCzvXn

New Issue :: Current Molecular Medicine 17, Issue 1

Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews, original research articles, short communications/letters and drug clinical trial studies on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal invites guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.

Articles from the journal Current Molecular Medicine 17, Issue 1:

• The Immune Function of Ly6Chi Inflammatory Monocytes During Infection and Inflammation
• Prion Function and Pathophysiology in Non-Mammalian Models
• Survival and Immunosuppression Induced by Hepatocyte Growth Factor in Chronic Lymphocytic Leukemia
• Molecular Determinants of Colon Cancer Susceptibility in the East and West
• Diabetes Type 4: A Paradigm Shift in the Understanding of Glaucoma, the Brain Specific Diabetes and the Candidature of Insulin as a Therapeutic Agent
• Molecular Determinants for STIM1 Activation During Store- Operated Ca2+ Entry
• Decreased HoxD10 Expression Promotes a Proliferative and Aggressive Phenotype in Prostate Cancer
• Evidence of PKC Binding and Translocation to Explain the Anticancer Mechanism of Chlorogenic Acid in Breast Cancer Cells

For details on the articles, please visit this link :: http://bit.ly/2t4tXl9

 

 

New Issue :: Medicinal Chemistry 13, Issue 3

Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.

Articles from the journal Medicinal Chemistry 13, Issue 3:

• Tamoxifen and Fulvestrant Hybrids Showed Potency as Selective Estrogen Receptor Down-Regulators
• Anti-inflammatory and Hypolipidemic Effect of Novel Conjugates with Trolox and Other Antioxidant Acids
• Anti-inflammatory, Analgesic and Anti-ulcerogenic Activities of Novel bis-thiadiazoles, bis-thiazoles and bis-formazanes
• Molecular Docking and Pharmacophore Modeling Studies of Fluorinated Benzamides as Potential CETP Inhibitors
• Antioxidant and Anticholinesterase Activities of Some Dialkylamino Substituted 3-Hydroxyflavone Derivatives
• Discovery of Flexible Naphthyltriazolylmethane-based Thioacetic Acids as Highly Active Uric Acid Transporter 1 (URAT1) Inhibitors for the Treatment of Hyperuricemia of Gout
• Elucidation of Antiangiogenic Potential of Vitexin Obtained from Cucumis sativus Targeting Hsp90 Protein: A Novel Multipathway Targeted Approach to Restrain Angiogenic Phenomena
• Gastrointestinal Motility and Acute Toxicity of Pistagremic Acid Isolated from the Galls of Pistacia integerrima
• Cytotoxic Phyllactone Analogs from the Marine Sponge Phyllospongia papyrecea
• A Microwave-Promoted/Assisted Method for Rapid Preparation of Biaryl Seven-membered Lactones

For details on the articles, please visit this link :: http://bit.ly/2tFdYMi

 

 

 

 

 

New Issue :: Current Pharmaceutical Analysis 13, Issue 3

Current Pharmaceutical Analysis publishes expert reviews and original research articles on all the most recent advances in pharmaceutical and biomedical analysis. All aspects of the field are represented including drug analysis, analytical methodology and instrumentation. The journal is essential to all involved in pharmaceutical, biochemical and clinical analysis.

Articles from the journal Current Pharmaceutical Analysis 13, Issue 3:

• Electrochemical DNA Biosensors in Drug Analysis
• RP-HPLC Method for the Analysis of Quercetin in Eruca Sativa with Green Solvent
• GC-MS Method for the Analysis of Thirteen Opioids, Cocaine and Cocaethylene in Whole Blood Based on a Modified Quechers Extraction
• Determination of Lactoferrin Content and the Total Antioxidant Capacity, in Animal, or Powdered Milks and Food Supplements Available in Drugstore, Using Biosensors. Study of the Possible Correlation Between Them
• An Impurity in Tenofovir Disoproxil Fumarate Exhibits High Human Organic Anion Transporter 1 Dependent Cytotoxicity
• Concurrent Estimation of Gabapentin and Nortriptyline Hydrochloride in their Combined Dosage Form Using OPA-β-Mercaptoethanol Derivatization by Spectrophotometric and Spectrofluorimetric Methods
• Stability Indicating Method for Determination of Sodium Picosulfate in Pharmaceutical Preparation – Comparison of HPLC, UHPLC and HTLC
• Bioactivities of Rubidium Chloride-Poly (4-Vinylpyridine) Composite Fabricated Via Sol Gel Technique
• Development and Validation of a Simple LC-UV Method to Assay Doxazosin in Polymeric Nanocapsules and Tablets
• Validated Stability-indicating RP-HPLC Method for the Determination of Parecoxib Sodium and Degradation Impurities in Bulk Drug
• A Novel Simultaneous Quantification Method for Escitalopram and Etizolam in Human Plasma Using Liquid Chromatography-ESI-Tandem Mass Spectrophotometry-Application to Pharmacokinetic Study
• Simultaneous Determination of Six Saponins in Panacis Japonici Rhizoma Using Quantitative Analysis of Multi-Components with Single-Marker Method
• An HPLC-MS/MS Method for the Quantitative Determination of Ticagrelor and its Active Metabolite AR-C124910XX in Human Plasma and its Application to a Clinical Study
• A Novel RP-HPLC Method for the Simultaneous Analysis of Some Active Ingredients in Cough–Cold Syrup Formulation
• Development and Validation of a Rapid UV-HPLC Method for the Determination of Anidulafungin in Perfusion Solution

For details on the articles, please visit this link :: http://bit.ly/2uIViuv