Infographics | Epigenetics: A Primer

THE BASICS

EPIGEGETICS: A PRIMER

There are many ways that epigenetic effects regulate the activation or repression of genes. Here are a few molecular tricks cells use to read off the right genetic program – By Stefan Kubicek

 

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AIMS & SCOPE – Current Stem Cell Research & Therapy

Aims & Scope

Current Stem Cell Research & Therapy publishes high quality frontier reviews, drug clinical trial studies and guest edited issues on all aspects of basic research on stem cells and their uses in clinical therapy. The journal is essential reading for all researchers and clinicians involved in stem cells research

 

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For more details, please visit: https://benthamscience.com/journals/current-stem-cell-research-and-therapy/aims-scope/#top

UPCOMING THEMATIC ISSUE – STEM CELL TARGETS TO OVARY REGENERATION – CURRENT STEM CELL RESEARCH & THERAPY

CSCRT-THEMATIC FLYER-Yang Yanzhou

https://benthamscience.com/journals/current-stem-cell-research-and-therapy/special-issues/

Highlighted Article Flyer for the journal “Current Stem Cell Research & Therapy”

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http://benthamscience.com/journals/current-stem-cell-research-and-therapy/

Highlighted Article Flyer for the journal “Current Stem Cell Research & Therapy”

CSCRT-Articles_11-3- Xie Jiamin

http://benthamscience.com/journals/current-stem-cell-research-and-therapy/

Most Downloaded Article ::: Amniotic Membrane Transplant for Articular Cartilage Repair: An Experimental Study in Sheep

Purpose: The aim of the present study was to compare the potential for cartilage repair of fresh amniotic membrane (AM), cryopreserved AM and cryopreserved AM previously cultured with bone marrow mesenchymal stem cells (BM-MSCs) in an in vivo sheep animal model. Methods: A full-thickness cartilage defect was surgically produced in 12 adult sheep, in the bearing region of the lateral femoral condyle. The animals were randomized into 4 groups (n=3): no treatment of the defect (G1); filling with fresh AM (G2); with cryopreserved AM previously cultivated with BM-MSCs (G3); with cryopreserved AM alone (G4). Postoperatively, the full load was possible. At two months, the animals were euthanized. The quality of the new synthesized tissue was evaluated with the macroscopic, by using International Cartilage Repair Society (ICRS) scale, and histological analyses, by using O’Driscoll scale. Results: The control samples showed an ICRS grade III (abnormal); while the samples of Groups 2, 3 and 4 reported a grade II (similar to healthy cartilage)…

Current Stem Cell Research & Therapy , 10(1): 77-83.

Download from here: http://bit.ly/1mbWAtl

MOST DOWNLAODED ARTICLE

Current Stem Cell Research & Therapy’s most viewed article on Academia

Amniotic Membrane Transplant for Articular Cartilage Repair: An Experimental Study in Sheep

Author(s): Diego Garcia, Umile Giuseppe Longo, Javier Vaquero, Francisco Forriol, Mattia Loppini, Wasim S. Khan and Vincenzo Denaro

Affiliation: University Campus Bio- Medico of Rome, Italy.

Abstract
Purpose: The aim of the present study was to compare the potential for cartilage repair of fresh amniotic membrane (AM), cryopreserved AM and cryopreserved AM previously cultured with bone marrow mesenchymal stem cells (BM-MSCs) in an in vivo sheep animal model. Methods: A full-thickness cartilage defect was surgically produced in 12 adult sheep, in the bearing region of the lateral femoral condyle. The animals were randomized into 4 groups (n=3): no treatment of the defect (G1); filling with fresh AM (G2); with cryopreserved AM previously cultivated with BM-MSCs (G3); with cryopreserved AM alone (G4). Postoperatively, the full load was possible. At two months, the animals were euthanized. The quality of the new synthesized tissue was evaluated with the macroscopic, by using International Cartilage Repair Society (ICRS) scale, and histological analyses, by using O’Driscoll scale. Results: The control samples showed an ICRS grade III (abnormal); while the samples of Groups 2, 3 and 4 reported a grade II (similar to healthy cartilage). The mean value of O’Driscoll scale in the control group (3.3) was significantly lower compared to the treatment groups (G2: 10.7; G3: 8; G4: 11.3) (P <0.05). No significant differences were found between the experimental groups. Conclusion: AM could be a suitable material for the management of articular cartilage defects. Stem cells within AM demonstrated to be able to differentiate in chondrocytes in vivo. Fresh AM, cryopreserved AM and cryopreserved AM previously cultivated with BM-MSCs showed similar regenerative properties.

Keywords: Amniotic membrane, cartilage repair, placenta, stem cell, tissue engineering.

Read the full article on Academia: http://bit.ly/1R5IqUV

Essential Journals on Stem Cell

Stem cell

Access articles of the journal Current Gene Therapy here: http://bit.ly/1rKbUzc

Access articles of the journal Current Stem Cell Research & Therapy here: http://bit.ly/1F2RCl5

Browse journals by subject here: http://bit.ly/1oNS4Sa

3 Breakthrough Developments in the Modern Medicine

Advances in the field of technology and medicine and breakthrough developments are being made every day. Diagnoses are expected to become more accurate than ever. Below are some of the examples of such medical breakthrough that can change the lives of millions.

1.            Human Organs created by stem cell

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Transplant of body organs are becoming difficult with the passing time, while some of them are extremely difficult to obtain causing more deaths. Today, there is technology that can create organs and body parts from the patient’s stem cells, increasing the chances of survival and decreasing the chances of rejection.  Kidneys are already being prepared with the help of stem cells. This is one of the greatest aspects of the future of regenerative medicine.

2.            Fast DNA diagnoses for Newborn

Newborns that are admitted to neonatal intensive care units suffer from genetic abnormalities inherited from their parents. DNA based testing if delivered swiftly can help the doctors interpret the newborn genome and the disease that they are liable to suffer.  Time is imperative for such newborns, while DNA testing takes a lot of time. The precarious situation of the newborns can be dealt with in an efficient manner if the results of DNA testing are given to the doctors as soon as possible. Initially it took a lot of time in interpreting these results, but thanks to the latest technology results can be delivered in only 50 hours.

3.            Reversing Autism

According to Autismspeaks.org, Autism spectrum disorder (ASD) and autism are both general terms for a group of complex disorders of brain development. These disorders are characterized, in varying degrees, by difficulties in social interaction, verbal and nonverbal communication and repetitive behaviors.

Early Start Denver Model claims to have helpedImage children suffering from autism can actually reverse the condition. It can actually work in the direction of normalizing the brain function. It already has shown 2 kids showing positive effects. This development has a significant chance of success.

[Borrowed from:

http://www.famousscientists.org/top-medical-breakthroughs-that-will-change-the-face-of-modern-medicine/]

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