Current issue: Burnout Syndrome in Emergency Physicians in Venezuela Early in the COVID-19 Pandemic

Author(s):Oscar Medina-Ortiz*Alejandro Oses GilJenny AlcendraGonzálezJuan Diego VivasMaría Parra SánchezLuis Parra SánchezManuel Riaño-GarzónMaría Judith Bautista-Sandoval and David Fraguas Herraez

Background: Burnout syndrome is a clinical entity that can negatively affect healthcare workers, especially frontline medical staff.

Objective: Determine the prevalence of burnout in emergency physicians at the start of the COVID-19 pandemic.

Methods: The Maslach Burnout Inventory was administered to 150 emergency physicians in 2020 during the first months of the pandemic in a Venezuelan hospital. There are two limitations, the size of sample is small and the study physicians have poor social conditions that do not allow generalizing the results.

Results: Over three quarters of the physicians surveyed (76.7%) experienced burnout and 55.3% had health problems due to stress. The higher the number of years working in the hospital and/or the lower the job satisfaction, the higher the burnout rate (p <0.05).

Conclusion: A large number of physicians in Venezuela experienced burnout during the first months of the pandemic, but half of them believed they did not need psychological help. Prevalence of burnout was high among physicians with more years of service and among those with lower job satisfaction.

Investigating the Effect of Stress Management Counseling on the Sexual Function of Infertile Women

Author(s):Arezoo ShayanSeyedeh Zahra MasoumiBatul Khodakarami*Hasan AhmadniaFatemeh Dastgerdian and Sogra Rabiei

Volume 18, Issue 4, 2022

Published on: 07 January, 2022

Article ID: e100921196373

Pages: 7

DOI: 10.2174/1573404817666210910120749


Background: Sexual dysfunction is one of the most common causes of family breakdown. In recent years, different approaches have been used to solve this problem. Due to the negative effects of sexual dysfunction in women and its complications.

Objective: The present study was conducted to investigate the effect of stress management counseling on the sexual function of infertile women referred to Fatemieh Hospital in Hamadan.

Methods: The present study was conducted as a randomized two-group clinical trial with two pretest and post-test stages on 104 eligible women referring to Fatemieh Hospital in Hamadan in 2017-2018. Intervention group subjects received 4 two-hour group counseling sessions with a cognitive- behavioral approach on sexual issues. Data were obtained using two questionnaires of demographic characteristics and the Female Sexual Function Index. To analyze the data, SPSS version 21 software and paired t-test, independent t-test, and analysis of covariance were used. The level of significance was considered to be less than 0.05.

Results: The results of the present study showed that the mean scores in all areas of total sexual function did not differ significantly before the intervention in two groups. However, after stress management counseling, a significant increase was observed in all areas and general sexual function in the intervention group compared to the control group (P <0.05).

Conclusion: Stress management counseling in infertile women can play a positive and effective role in improving sexual function. Therefore, the effectiveness of this counseling in promoting sexual function can be confirmed with more confidence. Read now:

OPEN ACCESS ARTICLE – The CRF Family of Neuropeptides and their Receptors – Mediators of the Central Stress Response

Journal Name: Current Molecular Pharmacology

Author(s): Nina Dedic, Alon Chen*, Jan M. Deussing.




Graphical Abstract:



Background: Dysregulated stress neurocircuits, caused by genetic and/or environmental changes, underlie the development of many neuropsychiatric disorders. Corticotropin-releasing factor (CRF) is the major physiological activator of the hypothalamic-pituitary-adrenal (HPA) axis and consequently a primary regulator of the mammalian stress response. Together with its three family members, urocortins (UCNs) 1, 2, and 3, CRF integrates the neuroendocrine, autonomic, metabolic and behavioral responses to stress by activating its cognate receptors CRFR1 and CRFR2.

Objective: Here we review the past and current state of the CRF/CRFR field, ranging from pharmacological studies to genetic mouse models and virus-mediated manipulations.

Results: Although it is well established that CRF/CRFR1 signaling mediates aversive responses, including anxiety and depression-like behaviors, a number of recent studies have challenged this viewpoint by revealing anxiolytic and appetitive properties of specific CRF/CRFR1 circuits. In contrast, the UCN/CRFR2 system is less well understood and may possibly also exert divergent functions on physiology and behavior depending on the brain region, underlying circuit, and/or experienced stress conditions.

Conclusion: A plethora of available genetic tools, including conventional and conditional mouse mutants targeting CRF system components, has greatly advanced our understanding about the endogenous mechanisms underlying HPA system regulation and CRF/UCN-related neuronal circuits involved in stress-related behaviors. Yet, the detailed pathways and molecular mechanisms by which the CRF/UCN-system translates negative or positive stimuli into the final, integrated biological response are not completely understood. The utilization of future complementary methodologies, such as cell-type specific Cre-driver lines, viral and optogenetic tools will help to further dissect the function of genetically defined CRF/UCN neurocircuits in the context of adaptive and maladaptive stress responses.




EDITOR’S CHOICE – Coping with Stress During Aging – Current Neuropharmacology

Journal: Current Neuropharmacology

Author(s): P. Sampedro-Piquero*, P. Alvarez-Suarez, A. Begega

Graphical Abstract:



Background: Resilience is the ability to achieve a positive outcome when we are in the face of adversity. It supposes an active resistance to adversity by coping mechanisms in which genetic, molecular, neural and environmental factors are involved. Resilience has been usually studied in early ages and few is known about it during aging.

Methods: In this review, we will address the age-related changes in the brain mechanisms involved in regulating the stress response. Furthermore, using the EE paradigm, we analyse the resilient potential of this intervention and its neurobiological basis. In this case, we will focus on identifying the characteristics of a resilient brain (modifications in HPA structure and function, neurogenesis, specific neuron types, glia, neurotrophic factors, nitric oxide synthase or microRNAs, among others).

Results: The evidence suggests that a healthy lifestyle has a crucial role to promote a resilient brain during aging. Along with the behavioral changes described, a better regulation of HPA axis, enhanced levels of postmitotic type-3 cells or changes in GABAergic neurotransmission are some of the brain mechanisms involved in resilience.

Conclusion: Future research should identify different biomarkers that increase the resistance to develop mood disorders and based on this knowledge, develop new potential therapeutic targets.

Read more here:



Pedraza Carmen

Contributed Article: “Stress, Depression, Resilience and Ageing: A Role for the LPA-LPA1 Pathway

Stress and Heart!

Everyone feels stressed in different ways and their reaction to it varies from person to person. Stress can lead to many health problems. When stressed some people panic, smoke, drink and overact and react.  All of these lead to many heart diseases. Stress may enhance factors that can cause heart disease like cholesterol, high blood pressure etc. Stress can also cause back strain, stomach pains and headache. A new study also shows that people who experience higher level of stress also have increased inflammations in the arteries which can lead to many heart problems.

Distressed young manager man holds her head with hand

A new study was presented at the American College of Cardiology’s 65th Annual Scientific Session. In that study imaging was used to look at 293 people’s brain and arteries. Researchers revealed that stress activity in an area of the brain called the amygdala, which is where emotions are processed, was linked to increased inflammation in a person’s arteries. It was noted that 35% of the people who experienced high stress suffered a heart event.

There are many techniques which can help a person to cope with stress. For instance, balanced diet and regular physical activity like yoga can help a person to relax, and stay happy and calm.

Blog ::: Stress Levels in Teens Effected By Use of Facebook

Facebook is the most popular social media website used worldwide. Among the most regular users of Facebook the count of teenagers is rapidly increasing. But most users do not realize that Facebook can have an impact on their psychological state.


Facebook can have positive and negative effects on teens levels of a stress hormone, researchers at the University of Montreal and the Institut universitaire de santé mentale de Montréal found. They conducted research on teenagers from ages 12 to 17 and discovered that users who had more than 300 friends on Facebook had higher level of cortisol, the enzyme which causes stress. While the users who tended to help or encourage their friends by posting comments or liking their published content were actually lowering their cortisol level.

There obviously are other contributors for the change in levels but the social media website has added itself to the list.

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