Open Access Articles | Antitumor Activity of Cyclodextrin-based Supramolecular Platinum Prodrug In vitro and In vivo

Journal Name: Letters in Drug Design & Discovery

Author(s): Yu-Hui Zhang, Jie Wang, Siqintana Xin, Li-Juan Wang, Xianliang Sheng*.

 

 

 

 

Graphical Abstract:

 

Abstract:

Background: Considering the limitations of cisplatin in clinical application, there is ongoing research to fabricate new platinum-containing prodrug which are highly effective to tumor cells and have low toxicity to normal cells.

Methods: In this study, a cyclodextrin-based supramolecular platinum prodrug that is 6,6’-ophenylenediseleno- bridged bis (β-cyclodextrin)s (CD) and its potassium tetrachloroplatinate(II) complex was reported. The cytotoxicity experiments were performed to evaluate the anticancer activities of supramolecular prodrug in vitro by means of MTT assay. The practical application of supramolecular prodrug in tumor treatment in vivo were evaluated using BALB/c nude mice model bearing Hela cancer cells.

Results: Compared with commercial anticancer drug cisplatin, the resultant cyclodextrin-based platinum prodrug exhibited comparative anticancer effect but with much lower toxicity side effects in vitro and in vivo.

Conclusion: The cyclodextrin-based supramolecular platinum prodrug displayed antitumor activity comparable to the commercial antitumor drug cisplatin but with lower side effects both in vitro and in vivo, implying that the two adjacent cyclodextrin cavities not merely act as desired solubilizer, but also endowed the prodrug with cell permeability through the interaction of cyclodextrin with phospholipids and cholesterol on cell membrane. To read out more, please visit: http://www.eurekaselect.com/172707/article

Aims & Scope | Mini-Reviews in Organic Chemistry

AIMS & SCOPE

Mini-Reviews in Organic Chemistryis a peer reviewed journal which publishes original reviews/mini reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges.

The journal encourages submission of reviews on emerging fields of organic chemistry including:

  • Bioorganic Chemistry
  • Carbohydrate Chemistry
  • Chemical Biology
  • Chemical Process Research
  • Computational Organic Chemistry
  • Development of Synthetic Methodologies
  • Functional Organic Materials
  • Heterocyclic Chemistry
  • Macromolecular Chemistry
  • Natural Products Isolation And Synthesis
  • New Synthetic Methodology
  • Organic Reactions
  • Organocatalysis
  • Organometallic Chemistry
  • Theoretical Organic Chemistry
  • Polymer Chemistry
  • Stereochemistry
  • Structural Investigations
  • Supramolecular Chemistry

 

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Become an Editorial Board Member (EBM) | Current Chinese Chemistry

 

Current Chinese Chemistry publishes original research articles, letters, reviews/mini-reviews and guest edited thematic issues dealing with various topics related to chemistry in China, while contributions from abroad are also welcome.

Current Chinese Chemistry is not limited to a specific aspect of the field but is instead devoted to a wide range of sub fields in the field. Articles of interdisciplinary nature are particularly welcome. Submission in the following areas are of special interest to the readers of this journal:

  • Physical Chemistry
  • Bioorganic Chemistry
  • Inorganic Chemistry
  • Biochemistry
  • Bioinorganic Chemistry
  • Environmental Chemistry
  • Organic Chemistry
  • Organometallic Chemistry
  • Medicinal Chemistry
  • Supramolecular Chemistry
  • Spectroscopy
  • Green Chemistry
  • Materials Chemistry

The Journal Current Chinese Chemistry is interested in appointing active Editorial Board Member  on the Journal’s Board. If you are working in the related field as of the journal and are interested in becoming an Editorial Board Member, please send us your CV and a list of publications. If, however, the scope of the journal is not directly related to your field, you can recommend suitable colleagues for the same, and, if possible, send their CV along with their list of publications. Mention in the subject line, the field of interest and send your CV at: hermain@benthamscience.net and CC: faizan@benthamscience.net

 

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Become a Reviewer | Current Chinese Chemistry

 

Current Chinese Chemistry publishes original research articles, letters, reviews/mini-reviews and guest edited thematic issues dealing with various topics related to chemistry in China, while contributions from abroad are also welcome.

Current Chinese Chemistry is not limited to a specific aspect of the field but is instead devoted to a wide range of sub fields in the field. Articles of interdisciplinary nature are particularly welcome. Submission in the following areas are of special interest to the readers of this journal:

  • Physical Chemistry
  • Bioorganic Chemistry
  • Inorganic Chemistry
  • Biochemistry
  • Bioinorganic Chemistry
  • Environmental Chemistry
  • Organic Chemistry
  • Organometallic Chemistry
  • Medicinal Chemistry
  • Supramolecular Chemistry
  • Spectroscopy
  • Green Chemistry
  • Materials Chemistry

The Journal Current Chinese Chemistry is interested in appointing active Reviewer on the Journal’s Board. If you are working in the related field as of the journal and are interested in becoming an Reviewer, please send us your CV and a list of publications. If, however, the scope of the journal is not directly related to your field, you can recommend suitable colleagues for the same, and, if possible, send their CV along with their list of publications. Mention in the subject line, the field of interest and send your CV at: hermain@benthamscience.net and CC: faizan@benthamscience.net

 

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Call for Papers | Current Chinese Chemistry

AIMS & SCOPE

Current Chinese Chemistry publishes original research articles, letters, reviews/mini-reviews and guest edited thematic issues dealing with various topics related to chemistry in China, while contributions from abroad are also welcome.

Current Chinese Chemistry is not limited to a specific aspect of the field but is instead devoted to a wide range of sub fields in the field. Articles of interdisciplinary nature are particularly welcome. Submission in the following areas are of special interest to the readers of this journal:

  • Physical Chemistry
  • Bioorganic Chemistry
  • Inorganic Chemistry
  • Biochemistry
  • Bioinorganic Chemistry
  • Environmental Chemistry
  • Organic Chemistry
  • Organometallic Chemistry
  • Medicinal Chemistry
  • Supramolecular Chemistry
  • Spectroscopy
  • Green Chemistry
  • Materials Chemistry

To submit your paper, email at: hermain@benthamscience.net and CC: faizan@benthamscience.net

 

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Aims & Scope | Current Organic Synthesis

Aims & Scope:

Current Organic Synthesis publishes in-depth reviews, original research articles and letter/short communications on all areas of synthetic organic chemistry i.e. asymmetric synthesis, organometallic chemistry, novel synthetic approaches to complex organic molecules, carbohydrates, polymers, protein chemistry, DNA chemistry, supramolecular chemistry, molecular recognition and new synthetic methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by experts who are internationally known for their eminent research contributions. The journal is essential reading to all synthetic organic chemists. Current Organic Synthesis should prove to be of great interest to synthetic chemists in academia and industry who wish to keep abreast with recent developments in key fields of organic synthesis.

 

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Find out more at: https://benthamscience.com/journals/current-organic-synthesis/aims-scope/#top

Highlighted Article Flyer for the journal “Current Organic Synthesis”

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