Dr. Yong-Ku Kim serves as the Editor-in-Chief of the Journal Current Psychiatry Research and Reviews
Department of Psychiatry, College of Medicine
Republic of Korea
Department of Psychiatry, College of Medicine
Republic of Korea
Author(s): Johanna Abrigo, Felipe Simon, Daniel Cabrera, Gonzalo Cordova, Capucine Trollet, Claudio Cabello-Verrugio*.
Among the soluble factors that regulate skeletal muscle function, Transforming Growth Factor type Beta 1 (TGF-β1) is one of the most studied. This factor inhibits myogenesis and regeneration by regulating the activity and function of satellite cells (SCs). Indeed, TGF-β has a central role in muscle pathologies in which there is development of fibrosis and/or atrophy of skeletal muscle. Thus, in this review we present the critical and recent antecedents regarding the mechanisms and cellular targets involved in the effects of TGF-β1 in the muscle, in pathological processes such as the inhibition of regeneration, fibrosis and atrophy. In addition, an update on the development of new strategies with therapeutic potential to inhibit the deleterious actions of TGF-β in skeletal muscle is discussed.
Background: Polyphenols are bioactive compounds that can be found mostly in foods like fruits, cereals, vegetables, dry legumes, chocolate and beverages such as coffee, tea and wine. They are extensively used in the prevention and treatment of cardiovascular disease (CVD) providing protection against many chronic illnesses. Their effects on human health depend on the amount consumed and on their bioavailability. Many studies have demonstrated that polyphenols have also good effects on the vascular system by lowering blood pressure, improving endothelial function, increasing antioxidant defences, inhibiting platelet aggregation and low-density lipoprotein oxidation, and reducing inflammatory responses.
Methods: This review is focused on some groups of polyphenols and their effects on several cardiovascular risk factors such as hypertension, oxidative stress, atherogenesis, endothelial dysfunction, carotid artery intima-media thickness, diabetes and lipid disorders.
Results: It is proved that these compounds have many cardio protective functions: they alter hepatic cholesterol absorption, triglyceride biosynthesis and lipoprotein secretion, the processing of lipoproteins in plasma, and inflammation. In some cases, human long-term studies did not show conclusive results because they lacked in appropriate controls and in an undefined polyphenol dosing regimen.
Conclusion: Rigorous evidence is necessary to demonstrate whether or not polyphenols beneficially impact CVD prevention and treatment.
Background: Epilepsy is one of chronic severe neurological disorders possess to recurring seizures. And now anti-epileptic drugs are only effective in less than one third of epilepsy patients, and biomarkers predicting are not available when the specific antiepileptic drugs treated. Advanced studies have showed that miRNA may be a key in the pathogenesis of epilepsy beginning in the early 2000 years. Several target genes and pathways of miRNA which related to the therapeutic methods to epilepsy.
Method: We searched PubMed from Jan 1,2000 to Jan 1, 2017, using the terms “epilepsy AND microRNA AND biomarker” and “seizure AND microRNA AND biomarker”. We selected articles that featured novel miRNAs in vivo epilepsy models and patients. We then selected the most relevant articles based on a subjective appraisal of their quality and mechanistic insight that could be relevant to epilepsy.
Results: Decrease the expression of has-miR134 could be a potential non-invasive biomarker to use in diagnosis for the epilepsy patients for using hsa-miR-134 also be identified to distinguish patients with and without epilepsy. miR-181a show significant downregulation in the acute stage, but up regulation in the chronic stage and in the latent stage there is no changing and how about this phenomenon appearance in different stage still should be discussed in the future. Besides that, miR- 146a can down-regulated in the patients using genome-wide for serum in circulating miRNAs.miR- 124, miR-199a, and miR-128 etc. could be a candidate for the biomarker in future. miR-15a-5p and -194-5p down-regulated in epilepsy patients, in the future, it may be used as a novel biomarker for improve diagnosis.
Conclusion: These observations give a chance that new development for diagnosis and treatment of epilepsy patients. Advanced technique and miRNA combination may product more effective roles in epilepsy and other disease. These reports will be available to solve the application of miRNAs as biomarkers and novel therapy approaches for epilepsy. In summary, researcher who focus on miRNAs should be understanding of the causes, treatment, and diagnosis of epilepsy. exploration of any of these effects on the efficacy of these drugs is worthwhile.
Read more here: http://www.eurekaselect.com/153652
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Research article on Polio
Current Status of Anti-Picornavirus Therapies
Current Drug Therapy publishes frontier reviews of high quality on all the latest advances in drug therapy and drug clinical trial studies and guest edited thematic issues covering: new and existing drugs, therapies and medical devices.The journal is essential reading for all researchers and clinicians involved in drug therapy.
Following are the articles from the recently published issue of the journal Current Drug Therapy, Volume 9- Issue 1:
Article: Editorial (Thematic Issue: Role of Molecular Bioports in Oral Delivery of Biomacromolecules)
Author(s): Rishi Paliwal, Shivani Rai Paliwal and Suresh P. Vyas
Affiliation: Rangel College of Pharmacy, Kingsville, Texas, USA.
Article: Therapeutic Implications of Immune Surveillance at the Intestinal Epithelial Barrier
Author(s): Olivia S. Sakhon and David D. Lo
Affiliation: Division of Biomedical Sciences, School of Medicine, University of California, 2146 Webber Hall, Room 2101, Riverside, California 92521-0121, USA.
Article: Mucosal Delivery of Vaccine by M Cell Targeting
Author(s): Tae-Eun Park, Bijay Singh, Sushila Maharjan, Tao Jiang, So-Yeon Yoon, Sang-Kee Kang, Jin-Duck Bok, Yun-Jaie Choi and Chong-Su Cho.
Affiliation: (Y-J. C) Department of Agricultural Biotechnology & Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-921, South Korea.
Article: Polymeric Nanocarriers for the Oral Delivery of Bioactives
Author(s): Rajeev Sharma, Udita Agrawal and Suresh P. Vyas
Affiliation: Drug Delivery 1Research Laboratory, Department of Pharmaceutical Sciences, Dr. H. S. Gour Viswavidyalaya, Sagar-470003 M.P, India.
Article: Lipid Nanoformulations for Oral Delivery of Bioactives: An Overview
Author(s): Ranjana Gupta, Anant Agrawal, Md. Meraj Anjum, Harinath Dwivedi, Koshy M. Kymonil and Shubhini A. Saraf.
Affiliation: Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, India.
Article: Challenges in Oral Delivery: Role of P-gp Efflux Pump
Author(s): Karan Mittal, Rajashree C. Mashru and Arti R. Thakkar
Affiliation: ISF College of Pharmacy, Moga India & Post-Doctoral Research Associate, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
Article: Thiomers, Mucoadhesion and Oral Delivery of Biomacromolecules
Author(s): Flavia Laffleur
Affiliation: Department of Pharmaceutical Technology, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Article: Colon as Target for Drug Delivery
Author(s): Anamika Sahu, Aviral Jain and Arvind Gulbake
Affiliation: Department of Pharmaceutics, Oriental College of Pharmacy, Bhopal (M.P.) 462021, India.
For details, please visit: http://benthamscience.com/journal/index.php?journalID=cdth
Current Stem Cell Research & Therapy, 10 Issue 1
Aims & Scope
Current Stem Cell Research & Therapy publishes high quality frontier reviews, drug clinical trial studies and guest edited issues on all aspects of basic research on stem cells and their uses in clinical therapy. The journal is essential reading for all researchers and clinicians involved in stem cells research
Abstracted & Indexed in:
Journal Citation Reports/Science Edition, Index to Scientific Reviews®, Science Citation Index Expanded (SciSearch®), BIOSIS Previews, BIOSIS Reviews Reports and Meetings, Chemical Abstracts, MEDLINE/PubMed, Scopus, EMBASE, PubsHub., Genamics JournalSeek, MediaFinder®-Standard Periodical Directory, and J-Gate.
For more details please visit: http://benthamscience.com/journal/index.php?journalID=cscrt