CALL FOR PAPERS | Thematic Issue for Current Medicinal Chemistry

 

Special Thematic Issues | Forthcoming Issues

Journal: Current Medicinal Chemistry

 

Guest Editor(s): Alexandru Mihai GRUMEZESCU
Tentative Publication Date: June, 2019

 

“REGENERATIVE MEDICINE AND TISSUE ENGINEERING”

Biomimetic scaffold which can mimic the native extracellular matrices have been developed by many research groups in order to improve the cell-scaffold interactions and to reach a new level of biocompatibility. These recent developments in the tissue construction area have lead to the idea that organ fabrication can be possible by using the available production techniques in combination with cells and growth factors to restore the function of an affected organ and even to increase the transplantation rate. Combining all those parameters together with the human body’s potential to heal in a proper environment, many products can be developed in order to diagnose and treat critical diseases from an early stage and to undertake the biggest crisis reported at the moment. The aim of this special issue is to present the latest updates in the field. For more details please visit: https://bit.ly/2LIe8PF

 

Email here to submit your paper: hermain@benthamscience.net

                                                          CC: faizan@benthamscience.net

 

OPEN ACCESS ARTICLE – Extracellular Matrix Scaffolds for Tissue Engineering and Regenerative Medicine

Journal Name: Current Stem Cell Research & Therapy

Author(s): Sheng Yi, Fei Ding, Leiiei Gong, Xiaosong Gu.

 

 

 

Abstract:

The extracellular matrix is produced by the resident cells in tissues and organs, and secreted into the surrounding medium to provide biophysical and biochemical support to the surrounding cells due to its content of diverse bioactive molecules. Recently, the extracellular matrix has been used as a promising approach for tissue engineering. Emerging studies demonstrate that extracellular matrix scaffolds are able to create a favorable regenerative microenvironment, promote tissue-specific remodeling, and act as an inductive template for the repair and functional reconstruction of skin, bone, nerve, heart, lung, liver, kidney, small intestine, and other organs. In the current review, we will provide a critical overview of the structure and function of various types of extracellular matrix, the construction of three-dimensional extracellular matrix scaffolds, and their tissue engineering applications, with a focus on translation of these novel tissue engineered products to the clinic. We will also present an outlook on future perspectives of the extracellular matrix in tissue engineering and regenerative medicine.

 

 

For more details, please visit: http://www.eurekaselect.com/145332

EDITORS CHOICE ARTICLE – Regenerating the Womb: The Good, Bad and Ugly Potential of the Endometrial Stem Cells

Journal Name: Current Regenerative Medicine

Author(s): Flaminia Bardanzellu*, Gavino Faa, Daniela Fanni, Vassilios Fanos, Maria Antonietta Marcialis.

 

Graphical Abstract:

Abstract:

The human endometrium is a very dynamic tissue undergoing an extraordinary growth during pregnancy and, in a cyclic manner, during the reproductive life of each woman. Endometrial stem cells (ESCs), undifferentiated auto-renewable cells able to generate daughter cells showing a higher level of differentiation, play a fundamental role in endometrial regeneration and repair. Therefore, they have a great therapeutic potential in many diseases and research fields.

However, recent data suggest that an irregular function of ESCs can contribute to the pathogenesis of endometriosis and other disorders. In addition, ESCs have also been found in human leiomyomas and malignant tumours, and could be involved in their development.

In this review we analyze the enormous regenerative potential of endometrium, which is, unfortunately, not exempted from its negative effects. This coexists with the good one as two faces of the same coin and constitutes the risk behind the fundamental protective and regenerative mechanisms to defend reproduction, and therefore the miracle of life itself.

READ MORE HERE: http://www.eurekaselect.com/164501/article

Most Accessed Article – “Modern 3D Printing Technologies: Future Trends and Developments”

Journal: Recent Patents on Engineering

Author(s): Om P. Singh, Sheikh. M. Ahmed and M Abhilash

Abstract: 

With the major advancements in 3D printing, it is now possible to print micro batteries to power small incest drones and many such devices that are used in stealth operations. Hence, 3D printing can be said as the embodiment of modern manufacturing processes. In this paper, we review the recent technological advancements in materials and in technological aspects of 3D printing, identify future challenges and potential applications in engineering, manufacturing and tissue engineering. A brief discussion is provided on patents filed in different fields such a materials, their applications and industry-wise patent filing trends.

Read more about this article here: http://benthamscience.com/journals/recent-patents-on-engineering/volume/9/issue/2/page/91/

Most Downloaded Article ::: Amniotic Membrane Transplant for Articular Cartilage Repair: An Experimental Study in Sheep

Purpose: The aim of the present study was to compare the potential for cartilage repair of fresh amniotic membrane (AM), cryopreserved AM and cryopreserved AM previously cultured with bone marrow mesenchymal stem cells (BM-MSCs) in an in vivo sheep animal model. Methods: A full-thickness cartilage defect was surgically produced in 12 adult sheep, in the bearing region of the lateral femoral condyle. The animals were randomized into 4 groups (n=3): no treatment of the defect (G1); filling with fresh AM (G2); with cryopreserved AM previously cultivated with BM-MSCs (G3); with cryopreserved AM alone (G4). Postoperatively, the full load was possible. At two months, the animals were euthanized. The quality of the new synthesized tissue was evaluated with the macroscopic, by using International Cartilage Repair Society (ICRS) scale, and histological analyses, by using O’Driscoll scale. Results: The control samples showed an ICRS grade III (abnormal); while the samples of Groups 2, 3 and 4 reported a grade II (similar to healthy cartilage)…

Current Stem Cell Research & Therapy , 10(1): 77-83.

Download from here: http://bit.ly/1mbWAtl

Current Stem Cell Research & Therapy’s most viewed article on Academia

Amniotic Membrane Transplant for Articular Cartilage Repair: An Experimental Study in Sheep

Author(s): Diego Garcia, Umile Giuseppe Longo, Javier Vaquero, Francisco Forriol, Mattia Loppini, Wasim S. Khan and Vincenzo Denaro

Affiliation: University Campus Bio- Medico of Rome, Italy.

Abstract
Purpose: The aim of the present study was to compare the potential for cartilage repair of fresh amniotic membrane (AM), cryopreserved AM and cryopreserved AM previously cultured with bone marrow mesenchymal stem cells (BM-MSCs) in an in vivo sheep animal model. Methods: A full-thickness cartilage defect was surgically produced in 12 adult sheep, in the bearing region of the lateral femoral condyle. The animals were randomized into 4 groups (n=3): no treatment of the defect (G1); filling with fresh AM (G2); with cryopreserved AM previously cultivated with BM-MSCs (G3); with cryopreserved AM alone (G4). Postoperatively, the full load was possible. At two months, the animals were euthanized. The quality of the new synthesized tissue was evaluated with the macroscopic, by using International Cartilage Repair Society (ICRS) scale, and histological analyses, by using O’Driscoll scale. Results: The control samples showed an ICRS grade III (abnormal); while the samples of Groups 2, 3 and 4 reported a grade II (similar to healthy cartilage). The mean value of O’Driscoll scale in the control group (3.3) was significantly lower compared to the treatment groups (G2: 10.7; G3: 8; G4: 11.3) (P <0.05). No significant differences were found between the experimental groups. Conclusion: AM could be a suitable material for the management of articular cartilage defects. Stem cells within AM demonstrated to be able to differentiate in chondrocytes in vivo. Fresh AM, cryopreserved AM and cryopreserved AM previously cultivated with BM-MSCs showed similar regenerative properties.

Keywords: Amniotic membrane, cartilage repair, placenta, stem cell, tissue engineering.

Read the full article on Academia: http://bit.ly/1R5IqUV

Brand New Podcast!!

You can view the Podcast from here: http://youtu.be/uEw2c_qyXT4

Title: MicroRNAs: Modulators of Cell Identity, and their Applications in Tissue Engineering by Dr. Luciana Vasques

Journal: MicroRNAs

Volume 3, 3 Issues, 2014

Abstract:

MicroRNAs post-transcriptionally regulate the expression of approximately 60% of the mammalian genes, and have an important role in maintaining the differentiated state of somatic cells through the expression of unique tissuespecific microRNA sets. Likewise, the stemness of pluripotent cells is also sustained by embryonic stem cell-enriched microRNAs, which regulate genes involved in cell cycle, cell signaling and epigenetics, among others. Thus, microRNAs work as modulator molecules that ensure the appropriate expression profile of each cell type. Manipulation of microRNA expression might determine the cell fate. Indeed, microRNA-mediated reprogramming can change the differentiated status of somatic cells towards stemness or, conversely, microRNAs can also transform stem- into differentiated-cells both in vitro and in vivo. In this Review, we outline what is currently known in this field, focusing on the applications of microRNA in tissue engineering.

For more information, please visit: http://benthamscience.com/journal/abstracts.php?journalID=mirna&articleID=122323