Aims & Scope | Current HIV Research

Aims & Scope

Current HIV Research covers all the latest and outstanding developments of HIV research by publishing original research, review articles and guest edited thematic issues. The novel pioneering work in the basic and clinical fields on all areas of HIV research covers: virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and transmission, anti-retroviral therapy and adherence, drug discovery, the latest developments in HIV/AIDS vaccines and animal models, mechanisms and interactions with AIDS related diseases, social and public health issues related to HIV disease, and prevention of viral infection. Periodically, the journal invites guest editors to devote an issue on a particular area of HIV research of great interest that increases our understanding of the virus and its complex interaction with the host.




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Press Release for EurekAlert! Virus-derived expression vectors as gene therapy vehicles

This research article by Dr. Srividhya Venkataraman et al has been published in Recent Patents on Biotechnology, Volume 11, Issue 2, 2017

Graphical Abstract:


Even as new viruses are being identified, the emerging field of virus discovery, identification of their nucleotide sequences, gene expression patterns and complexities of virus-host interactions at the molecular level are being used in recent years towards applications in the human medicine as well as veterinary, agricultural and other biotechnological purposes. Several patents pertaining to this field have been filed successfully and the current review addresses recent patents pertaining to the use of virus sequences as RNA silencing agents and virus-derived expression vectors as gene therapy vehicles. Specifically, these patents demonstrate the use of viral sequences to silence positive-sense RNA viruses such as Flaviviruses, Picornaviruses, Togaviruses, Herpesviruses and minus-stranded RNA viruses such as Filoviruses, virus-induced gene silencing in plants, expression vectors of Poxviruses, Flaviviruses, Influenza viruses, Adeno-associated viruses, expression vectors based on plant viruses and viral expression vectors applicable to the fish industry. Virus-derived short double-stranded RNAs and DNA-based antisense antiviral compounds are used at low dosage to specifically and effectively mediate RNA interference or RNA silencing and downregulate viral replication. Also, Virus-Induced Gene Silencing (VIGS) is used to identify gene functions in plants. Expression vectors based on poxviruses engineered to code for HIV and other viral immunogens are popular vaccine candidates. Pseudoinfectious viruses that can undergo a single round of infection in vivo, mimicking whole viral infections while inducing strong T- and B-cell immunity are also discussed. Another patent discusses a multi-vector scheme for generating recombinant and reassortant Influenza Viruses. A recombinant Papaya Mosaic Virus coat protein forming virus-like particles (VLPs) with Influenza Virus epitopes exposed on their surface is also mentioned. However, the current inventions addressed in these patents require scrupulous testing in clinical trials (for medical and veterinary uses) and field trials (for agricultural uses) that are yet to be achieved. It is also important to consider the influence of prior host-environment interactions and the previous history of exposure to pathogenic organisms. Testing of these virus-derived genetically engineered vehicles has to go further beyond mere success in laboratory-derived cell culture systems and experimental animals / plants.

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