Most Cited Article – Prediction of Potential Targets of an Emerging Zoonotic Paramyxovirus: An Integrated Bioinformatics Analysis

Author(s):Minnikanti Venkata Satya SaiViswam SubeeshHema Sree GNSGaneshan Rajalakshmi Saraswathy and Nair Gouri*


Background: Nipah virus (NiV) is a zoonotic paramyxovirus that can cause severe respiratory illness and encephalitis in humans, with no effective targets and treatment.

Objective: To investigate potential targets involved in the progression of NiV infection by bioinformatics studies.

Methods: To identify the key gene involved in NiV infection, a microarray dataset (GSE32902) was downloaded from the National Centre of Biotechnology Information (NCBI). The differentially expressed genes were unraveled by using Geo2Enrichr, and the functional enrichment analysis was facilitated by using Database for Annotation, Visualization, and Integrated Discovery (DAVID). Search Tool for the Retrieval of Interacting Genes (STRING) was used to construct the Protein-protein interaction (PPI) network and visualized by using Cytoscape.

Results: A total of 500 genes (262 up-regulated and 238 down-regulated) were identified among NiV infected cells. Nineteen upregulated genes were found with a node degree of more than 10, Among which MX1, ISG15, and IFIT1 were found to have the highest node degree (degree=20), followed by RSAD2 and IRF7 with node degree 18 and MX2 and IFIT3 with node degree 17.

Conclusion: The above results explicitly demonstrate that the expressed genes attribute to a defensive response against the virus. Henceforth finding agonists for these genes would help in the effective management of Niv infection. Read Now:

EurekAlert! – Application of novel alignment-free sequence descriptors in Zika virus characterization

Dr. Basak and his colleagues explained about their research on computer-assisted approaches towards surveillance and consequent design of drugs and vaccines to combat the growth and spread of the Zika virus.

The recent epidemic of Zika virus infections in South and Latin America has raised serious concerns on its ramifications for the population in the Americas and spread of the virus worldwide. The Zika virus disease is a relatively new phenomenon for which sufficient and comprehensive data and investigative reports have not been available to date. Although first recognized as a new virus in 1947 in Uganda’s Zika forest animals, its debilitating effect on human fetuses leading to babies being born with smaller braincases (microcephaly) was not known or well investigated until its epidemic form in Yap Island, Micronesia, in 2013 and now in the South American countries in 2015-16. The concern is so high that public health authorities in some countries such as Colombia, Ecuador, El Salvador, and Jamaica have asked their women to avoid pregnancies until the virus is better understood. The World Health Organization (WHO) has labeled the outbreak of such abnormalities as a Public Health Emergency of International Concern.


Dr. Subhash Basak

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