Author(s): Seon Woong Kim, Taeho Lee, Joo-Youn Lee, Sanghee Kim, Hee-Sook Jun, Eun-Young Park*, Dong Jae Baek*.
PF-543 has been known as a substance that strongly inhibits SK1. However, it also exhibits antineoplastic activity that is lower than other inhibitors of SK1. In this study, we compared PF-543 and synthesized a newly designed derivative of PF-543 (compound 2) in which two aromatic structures were connected in para-form. The synthesized derivative showed inhibitory effect on SK1, similar to that of PF-543. However, it was more cytotoxic to HT29, AGS, and PC3 cells than PF-543. We also carried out a docking study for SK1 and demonstrated that the synthesized derivative showed interaction with SK1 similar to PF-543. Results obtained from this study suggest that the structure of compound 2 may be well substituted for the structure of PF-543 in terms of biological activity, providing us important structural information for the design of new derivatives of PF-543. Read out full article here: http://www.eurekaselect.com/166082
Author: Bentham Science
Bentham Science is a leading publishing company in the field of science, technology, and medicine. Established in 1992, the company has grown to become one of the most reputable and respected publishers in the scientific community.
Bentham Science publishes more than 100 online and print journals, along with over 300 eBooks and over 2000 reference works. These publications cover a wide range of topics, including pharmaceutical sciences, biotechnology, chemistry, engineering, and more.
In addition to its publications, Bentham Science also provides various services to the scientific community, including manuscript editing, article formatting, and language polishing. The company is committed to promoting scientific research and discovery by providing a platform for researchers to share their work with a wider audience.
Bentham Science's reputation for excellence is built on a commitment to quality, integrity, and innovation. Its editorial team consists of experts in their respective fields who ensure that all publications are rigorously peer-reviewed and meet the highest standards of scientific accuracy.
Overall, Bentham Science is an invaluable resource for scientists, researchers, and academics who are looking to stay up-to-date on the latest developments in their fields. With its wide range of publications and commitment to quality, the company is poised to remain a leader in the scientific publishing industry for years to come.
View all posts by Bentham Science
Bentham Science 